rs17879961
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found an even stronger significant association between the CHEK2 I157T C variant and increased risk of lobular type breast tumors (OR = 4.17, 95% CI = 2.89-6.03, P < 0.0001).
|
22799331 |
2012 |
rs17879961
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our analyses suggest that there are fundamental differences in breast tumors of CHEK2:p.I157T and c.1100delC carriers.
|
27716369 |
2016 |
rs778212685
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The observation of BRCA2 -26 G/A 5'UTR polymorphism concomitant with the presence of methylation in the promoter region was novel and emerged as a strong candidate for susceptibility to sporadic breast tumors.
|
21092294 |
2010 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
|
18085035 |
2007 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
CHEK2-positive breast cancers in young Polish women.
|
16914568 |
2006 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
|
18571837 |
2008 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.
|
16551709 |
2006 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.
|
27153395 |
2016 |
rs137853011
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
|
15649950 |
2005 |
rs1555913881
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
|
15145354 |
2004 |
rs555607708
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma.
|
28514723 |
2017 |
rs587780170
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
|
17721994 |
2007 |
rs786202676
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
CHEK2 contribution to hereditary breast cancer in non-BRCA families.
|
22114986 |
2011 |