|
rs2303790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among them, CETP (rs3764261/rs2303790) and ABCG1 (rs57137919) were the major susceptibility genes for PCV in Asian population and ABCG1 (rs57137919) showed allelic diversity between PCV and AMD.
|
29977615 |
2018 |
|
rs754100400
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel variant, c.6196A>G in the IGFN1 gene, was significantly associated with only PCV (combined p = 7.1 × 10<sup>-11</sup> , odds ratio = 9.44), but not with nAMD (combined p = 0.683, odds ratio = 1.30).
|
29323771 |
2018 |
|
rs11775442
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the Hong Kong cohort, four SNPs in ANGPT2 (rs13255574, rs4455855, rs13269021, and rs11775442) were nominally associated with nAMD and PCV.
|
28192798 |
2017 |
|
rs13269021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the Hong Kong cohort, four SNPs in ANGPT2 (rs13255574, rs4455855, rs13269021</span>, and rs11775442) were nominally associated with nAMD and PCV.
|
28192798 |
2017 |
|
rs4455855
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Combining the data from the 3 study cohorts revealed that SNPs rs4455855 and rs13269021 achieved study-wise significance (P < 0.0016), conferring an approximately 1.3-fold of increased risk for nAMD and PCV.
|
28192798 |
2017 |
|
rs1049331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs1329428
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subfoveal choroidal thickness and CVH in eyes with treatment-naive polypoidal choroidal vasculopathy were associated with ARMS2 A69S (rs10490924) and CFH (rs1329428).
|
26745149 |
2016 |
|
rs225396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have newly identified a haplotype-tagging SNP, rs225396, in ABCG1 to be associated with PCV and nAMD in Chinese and Japanese cohorts.
|
27787563 |
2016 |
|
rs2293870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs2672598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results revealed that HTRA1 rs2672598 is more significantly associated with exudative AMD than PCV in ARMS2/HTRA1 region, and it is responsible for elevated HTRA1 transcriptional activity and HTRA1 protein expression.
|
27338780 |
2016 |
|
rs369149111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV.
|
27338780 |
2016 |
|
rs77466370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Exome sequencing analysis of a Han Chinese cohort followed by replication in four independent cohorts identified a rare c.986A>G (p.Lys329Arg) variant in the FGD6 gene as significantly associated with PCV (P = 2.19 × 10(-16), odds ratio (OR) = 2.12) but not with CNV (P = 0.26, OR = 1.13).
|
27089177 |
2016 |
|
rs1065489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, CFH rs1065489 did not show significant association with nAMD (P>0.01), but was strongly associated with PCV in Chinese patients (P<0.001).
|
25771815 |
2015 |
|
rs13095226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This case-control study indicated that the COL8A1 rs13095226 polymorphism is not associated with nAMD or PCV, which suggesting this gene maybe not a susceptibility gene locus for nAMD or PCV in Chinese subjects.
|
26617902 |
2015 |
|
rs1532085
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also first found the association between rs1532085 and PCV.
|
26624898 |
2015 |
|
rs2217332
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed that HERPUD1 rs2217332 is significant associated with Chinese PCV, and HERPUD1 was expressed in PCV subretinal membranes.
|
26823705 |
2015 |
|
rs2274700
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The one-marker model, rs3750847, and two-locus model rs2274700_rs3750847 has a balanced accuracy of 66.07% and 65.89% in predicting PCV disease risk, respectively.
|
25771815 |
2015 |
|
rs3750847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The one-marker model, rs3750847, and two-locus model rs2274700_rs3750847 has a balanced accuracy of 66.07% and 65.89% in predicting PCV disease risk, respectively.
|
25771815 |
2015 |
|
rs868005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allelic association analyses, rs868005 showed the strongest association with Type 2 PCV (allelic odds ratio 1.56; p = 7.4x10(-6)), while no SNP was significantly associated with Type 1 PCV.
|
25775011 |
2015 |
|
rs943080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found to support the role for the rs833069, rs943080 and rs4711751 variants of or near VEGFA gene in susceptibility to either PCV or neovascular AMD in Han Chinese population.
|
24303777 |
2015 |
|
rs10033900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our case-control study, neither of the two SNPs most studied (rs10033900 or rs2285714) in the CFI gene was a risk factor for developing nAMD or PCV in a Chinese population.
|
24732209 |
2014 |
|
rs1042229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygous G allele of rs1042229 was associated with exudative AMD (P=0.0394, odds ratio (OR)=2.27, 95% confident interval: 1.08-4.74), but not with PCV.
|
25277308 |
2014 |
|
rs17030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study shows an association of C3 rs17030 with PCV i</span>n male, indicating that C3 may have an epistatic effect with gender in the pathogenesis of PCV.
|
25388911 |
2014 |
|
rs1883025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that ABCA1 rs1883025 variants are not associated with nAMD or PCV in a Chinese population, which is likely due to an ethnic difference.
|
24685762 |
2014 |
|
rs1999930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs4711751 and rs1999930 are not associated with neovascular age-related macular degeneration or polypoidal choroidal vasculopathy in the Chinese population.
|
25228097 |
2014 |