|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Factor V Leiden, PTH G20210A and MTHFR C677T polymorphisms were detected in 40 cancer patients with VTE (group 1) and 40 cancer patients with no evidence of VTE (group 2) by PCR-based DNA analysis.
|
25565385 |
2015 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T had no association with VTE risk in pregnancy (ORG 1.24; 95% CI 0.88-1.73).
|
26115054 |
2015 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant association with VTE was found for homozygous C677T MTHFR (OR: 1.38; 95 % confidence intervals [CI]: 0.98-1.93), whereas the risk was increased in carriers of either heterozygous FVL or PT20210 (OR = 4.22; 95 % CI: 3.35-5.32; and OR = 2.79;95 % CI: 2.25-3.46, respectively), in double heterozygotes (OR = 3.42; 95 %CI 1.64-7.13), and in homozygous FVL or PT20210A (OR = 11.45; 95 %CI: 6.79-19.29; and OR: 6.74 (CI 95 % 2.19-20.72), respectively).
|
23900608 |
2013 |
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rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Factor V leiden G1691A/R506Q (FVL), prothrombin G20210A (FII) and methylenetetrahydrofolate reductase (MTHFR) C677T are related genetic risk factors for venous thromboembolism.
|
22528331 |
2012 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, frequencies of FV G1691A, PT G20210A, and MTHFR C677T mutations are higher in patients with VTE.
|
21078611 |
2012 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Factor V Leiden (Factor V G1691A), prothrombin gene mutation G20210A, and homozygous C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene are known to predispose venous thromboembolism (VTE).
|
19520679 |
2010 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients were interviewed about VTE risk factors and tested for factor V Leiden (FVL), prothrombin G20210A (PT), methylenetetrahydrofolate reductase C677T homozygosity (MTHFR), lupus anticoagulant, homocysteine (Hcy) and plasma factor VIII (FVIII) levels.
|
19853891 |
2010 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we have focused on the prevalence of methylenetetrahydrofolate reductase (MTHFR) C677T, dihydrofolate reductase (DHFR) 19-bp deletion within intron 1, factor V Leiden (FVL), and prothrombin (PT) G20210A polymorphisms in cancer patients with and without VTE.
|
18682947 |
2009 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR/ C677T in Chinese/Thai populations (OR 1.57; 95% CI 1.23-2.00, p = 0.0003), and ACE I/D in African American populations (OR 1.5; 95% CI 1.03-2.18, p = 0.03) were found to be significantly associated with VTE.
|
19652888 |
2009 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T mutation of the methylenetetrahydrofolate reductase gene, which may lead to hyperhomocysteinemia, is also considered a risk factor for VTE in some studies.
|
17401546 |
2007 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T mutations are considered risk factors for venous thromboembolism.
|
15886665 |
2005 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Insofar as the inherited prothrombotic single nucleotide polymorphisms (SNPs) factor V G1691A (FV-Leiden), prothrombin (PRT) G20210A, and methylenetetrahydrofolate reductase (MTHFR), C677T are inherited risk factors of venous thromboembolism (VTE), the aim of this study was to determine the prevalence of single and combined SNPs in 198 patients with documented deep venous thrombosis (DVT), and 697 control subjects, and to estimate the associated risks.
|
16082606 |
2005 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single point mutations in the genes coding for factor V [G1691A; Leiden], prothrombin [PRT; G20210A], and methylenetetrahydrofolate reductase [MTHFR, C677T] were shown to be major inherited predisposing factors for venous thromboembolism.
|
15353918 |
2004 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No associations between VTE and MTHFR polymorphisms (C677T, A1298C) were found.
|
12570104 |
2003 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Factor V Leiden, prothrombin 20210G --> A, methylenetetrahydrofolate reductase 677C --> T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism.
|
14597244 |
2003 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prothrombin 20210 G-->A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy.
|
10759281 |
2000 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequencies of Factor V G1691A (FVL), prothrombin (PT) G20210A, 5'10'methylenetetrahydrofolate reductase (MTHFR) C677T, and methionine synthase (MS) A2756G (four mutations associated with an increased risk of venous thromboembolism [VTE]) were determined in a sample of approximately 1500 New York State residents.
|
10963782 |
2000 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggests that the homozygous C677T mutation in the MTHFR gene might be a risk factor of VTE in patients with spontaneous events and without other common genetic risk factors.
|
11124649 |
2000 |
|
rs1188383936
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping for mutations that are possible causes of moderate hyperhomocysteinemia, such as the thermolabile variant (C677T) of methylenetetrahydrofolate reductase (MTHFR), does not seem useful to identify individuals at higher risk for venous thromboembolism.
|
11011848 |
2000 |