Gene: PRKN ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs55774500
rs55774500
PRKN
0.800 GeneticVariation UNIPROT EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease. 23279440

2013
dbSNP: rs191486604
rs191486604
PRKN
T 0.800 GeneticVariation CLINVAR Mutations in the parkin gene are a minor cause of Parkinson's disease in the South African population. 21996382

2012
dbSNP: rs137853054
rs137853054
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs137853057
rs137853057
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs137853058
rs137853058
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs137853060
rs137853060
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs147757966
rs147757966
PRKN
T 0.800 CausalMutation CLINVAR Impact of autosomal recessive juvenile Parkinson's disease mutations on the structure and interactions of the parkin ubiquitin-like domain. 21348451

2011
dbSNP: rs147757966
rs147757966
PRKN
T 0.800 CausalMutation CLINVAR Autoregulation of Parkin activity through its ubiquitin-like domain. 21694720

2011
dbSNP: rs34424986
rs34424986
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs397514694
rs397514694
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs55774500
rs55774500
PRKN
0.800 GeneticVariation UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486

2011
dbSNP: rs137853054
rs137853054
PRKN
0.800 GeneticVariation UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974

2010
dbSNP: rs137853054
rs137853054
PRKN
0.800 GeneticVariation UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs137853057
rs137853057
PRKN
0.800 GeneticVariation UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs137853057
rs137853057
PRKN
0.800 GeneticVariation UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974

2010
dbSNP: rs137853058
rs137853058
PRKN
0.800 GeneticVariation UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974

2010
dbSNP: rs137853058
rs137853058
PRKN
0.800 GeneticVariation UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs137853060
rs137853060
PRKN
0.800 GeneticVariation UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974

2010
dbSNP: rs137853060
rs137853060
PRKN
0.800 GeneticVariation UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs191486604
rs191486604
PRKN
T 0.800 CausalMutation CLINVAR The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. 20798600

2010
dbSNP: rs191486604
rs191486604
PRKN
T 0.800 CausalMutation CLINVAR PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs191486604
rs191486604
PRKN
T 0.800 CausalMutation CLINVAR p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. 20604804

2010
dbSNP: rs191486604
rs191486604
PRKN
T 0.800 GeneticVariation CLINVAR p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. 20604804

2010
dbSNP: rs34424986
rs34424986
PRKN
0.800 GeneticVariation UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107

2010
dbSNP: rs34424986
rs34424986
PRKN
0.800 GeneticVariation UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974

2010