|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
11717358 |
2001 |
|
rs121912443
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
11717358 |
2001 |
|
rs1426039367
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
11717358 |
2001 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We analyzed the molecular mechanism underlying motor neuron degeneration in the transgenic mouse model expressing the SOD1 gene with G93A mutation.
|
11796754 |
2002 |
|
rs1475170339
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We analyzed the molecular mechanism underlying motor neuron degeneration in the transgenic mouse model expressing the SOD1 gene with G93A mutation.
|
11796754 |
2002 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Transgenic mice overexpressing the human mutated form (G93A) of Cu,Zn-superoxide dismutase (mSOD1) develop motor neuron degeneration resembling amyotrophic lateral sclerosis.
|
14625013 |
2003 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
16382787 |
2005 |
|
rs1475170339
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
16382787 |
2005 |
|
rs121912443
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
16382787 |
2005 |
|
rs1426039367
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor neuron degeneration and paralysis.
|
16382787 |
2005 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient.
|
16740261 |
2006 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While previous studies have demonstrated reductions in GLT1 with SOD1-mediated disease progression, it is not well established whether a reduction in this astrocyte-specific transporter alters the pathobiology of motor neuron degeneration in the SOD1(G93A) mouse.
|
16753145 |
2006 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To test whether ALS2 plays a protective role against mutant SOD1-mediated motor neuron degeneration in vivo, we examined the progression of motor neuron disease in SOD1(G93A) mice on an ALS2 null background.
|
16973244 |
2007 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results show that disruption of BBB and BSCB was evident in areas of motor neuron degeneration in G93A mice at both early and late stages of disease.
|
17512910 |
2007 |
|
rs1475170339
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results show that disruption of BBB and BSCB was evident in areas of motor neuron degeneration in G93A mice at both early and late stages of disease.
|
17512910 |
2007 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For this reason, we analyzed the temporal response of NPCs to motor neuron degeneration in the spinal cord and brain using nestin enhancer-driven LacZ reporter transgenic mice (pNes-Tg mice, control) and bi-transgenic mice containing both the nestin enhancer-driven LacZ reporter gene and mutant G93A-SOD1 gene (Bi-Tg mice).
|
17784831 |
2007 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, the role of astrocyte proliferation was assessed in both acute and chronic mouse models of motor neuron degeneration, neuroadapted sindbis virus (NSV)-infected mice and SOD1(G93A) mice, respectively.
|
18410928 |
2008 |
|
rs762060740
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, the role of astrocyte proliferation was assessed in both acute and chronic mouse models of motor neuron degeneration, neuroadapted sindbis virus (NSV)-infected mice and SOD1(G93A) mice, respectively.
|
18410928 |
2008 |
|
rs121909342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single amino acid change, G59S, in the conserved cytoskeletal-associated protein glycine-rich (CAP-Gly) domain of the p150(glued) subunit of dynactin can cause motor neuron degeneration in humans and mice, which resembles ALS (2, 5-8).
|
19279216 |
2009 |
|
rs1394871648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single amino acid change, G59S, in the conserved cytoskeletal-associated protein glycine-rich (CAP-Gly) domain of the p150(glued) subunit of dynactin can cause motor neuron degeneration in humans and mice, which resembles ALS (2, 5-8).
|
19279216 |
2009 |
|
rs759299980
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single amino acid change, G59S, in the conserved cytoskeletal-associated protein glycine-rich (CAP-Gly) domain of the p150(glued) subunit of dynactin can cause motor neuron degeneration in humans and mice, which resembles ALS (2, 5-8).
|
19279216 |
2009 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Taken together, this suggests that reduced levels of VGLUT2 decrease motor neuron degeneration but do not prevent loss of motor neuron function in the SOD1(G93A) mouse model for ALS.
|
19770042 |
2010 |
|
rs781978795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together, this suggests that reduced levels of VGLUT2 decrease motor neuron degeneration but do not prevent loss of motor neuron function in the SOD1(G93A) mouse model for ALS.
|
19770042 |
2010 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Acute glial activation by stab injuries does not lead to overt damage or motor neuron degeneration in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.
|
20005223 |
2010 |
|
rs121912438
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, in the present study, we investigated the process of motor neuron degeneration as the disease progresses and to determine whether the CypA-AIF complex would play a role in inducing motor neuronal cell death in mutant superoxide dismutase 1 (SOD1)(G93A) ALS model mice.
|
20553309 |
2011 |