Gene: BRCA1 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs80357522
rs80357522
BRCA1
CT 0.700 GeneticVariation CLINVAR

dbSNP: rs80357678
rs80357678
BRCA1
C 0.700 GeneticVariation CLINVAR

dbSNP: rs80357750
rs80357750
BRCA1
0.020 GeneticVariation BEFREE The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. 19876733

2010
dbSNP: rs80357750
rs80357750
BRCA1
0.020 GeneticVariation BEFREE Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk. 17220212

2007
dbSNP: rs80357796
rs80357796
BRCA1
0.030 GeneticVariation BEFREE The rare form of the Q356R polymorphism was significantly ( P = 0.03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk. 10196379

1999
dbSNP: rs80357796
rs80357796
BRCA1
0.030 GeneticVariation BEFREE No association was detected between EOC risk and BRCA1 Q356R, BRCA1 P871L, RAD51 g135c, RAD51 g172t, RAD52 c2259t, NBS1 L34L, NBS1 E185Q, NBS1 A399A, NBS1 P672P, XRCC2 g4324c, XRCC2 c41657t and XRCC3 T241M. 15924337

2005
dbSNP: rs80357796
rs80357796
BRCA1
0.030 GeneticVariation BEFREE We resequenced BRCA1 and BRCA2 in 194 women with a familial history of breast and/or ovarian cancer and identified nine possibly biologically relevant polymorphisms (BRCA1 Gln356Arg, Pro871Leu, Glu1038Gly, Ser1613Gly, and Met1652Ile. 19661094

2009
dbSNP: rs876660702
rs876660702
BRCA1
0.010 GeneticVariation BEFREE The BRCA1 G5193A mutation is too rare to contribute significantly to ovarian cancer in Iceland. 15571962

2004
dbSNP: rs879255288
rs879255288
BRCA1
0.010 GeneticVariation BEFREE Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer. 20437199

2010
dbSNP: rs886039920
rs886039920
BRCA1
0.020 GeneticVariation BEFREE Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk. 17220212

2007
dbSNP: rs886039920
rs886039920
BRCA1
0.020 GeneticVariation BEFREE The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. 19876733

2010