TLX1NB, TLX1 neighbor, 100038246

N. diseases: 31; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235833
Disease: Congenital diaphragmatic hernia
Congenital diaphragmatic hernia
0.010 GeneticVariation disease BEFREE <b>Conclusion:</b> The signs of both systolic and diastolic altered function were observed in fetuses with CDH with s-TDI independent of the side of the hernia, and a significant positive correlation was observed between fetal cardiac systolic function and the severity of pulmonary hypoplasia. 31588831 2020
CUI: C0265783
Disease: Congenital hypoplasia of lung
Congenital hypoplasia of lung
0.010 Biomarker disease BEFREE <b>Conclusion:</b> The signs of both systolic and diastolic altered function were observed in fetuses with CDH with s-TDI independent of the side of the hernia, and a significant positive correlation was observed between fetal cardiac systolic function and the severity of pulmonary hypoplasia. 31588831 2020
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.010 GeneticVariation disease BEFREE Measuring P-A'TDI interval identifies patients with chronic heart failure at higher risk of dying or developing atrial fibrillation during follow-up. 30985354 2019
CUI: C0015672
Disease: Fatigue
Fatigue
0.010 Biomarker phenotype BEFREE A near-infrared fluorescence-switchable molecule, dithienylethene-terrylenediimide (TDI-4DTE) exhibits high near-infrared fluorescence and on/off ratio, decent reversibility, and fatigue resistance upon alternating UV/vis (305/621 nm) irradiation. 31179680 2019
CUI: C0264716
Disease: Chronic heart failure
Chronic heart failure
0.010 Biomarker disease BEFREE Measuring P-A'TDI interval identifies patients with chronic heart failure at higher risk of dying or developing atrial fibrillation during follow-up. 30985354 2019
CUI: C0013404
Disease: Dyspnea
Dyspnea
0.010 Biomarker phenotype BEFREE The evaluation of medical history and clinical data of ALS patients showed that patients with perception of dyspnea (TDI 25.7 ± 8.0) performed significantly worse in olfactory testing compared to those who did not (TDI 30.0 ± 7.4). 29535673 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.010 Biomarker disease BEFREE Controlling for confounding factor, in male schizophrenia participants, the negative subscale score was significantly and inversely correlated with the discrimination (γ = - 0.37, p < 0.008), identification (γ = - 0.45, p < 0.008) and TDI (γ = - 0.50, p < 0.008) scores; the general psychopathology subscale score was inversely and significantly correlated with the identification (γ = - 0.47, p < 0.008) and TDI (γ = - 0.41, p < 0.008) scores. 29914416 2018
CUI: C0340392
Disease: Functional tricuspid regurgitation
Functional tricuspid regurgitation
0.010 Biomarker disease BEFREE An enlarged TA dimension was associated with outcomes irrespective of subgroups according to type or severity of TR and TDI s' (p = 0.21, p = 0.77, p = 0.15 for interaction). 29580628 2018
CUI: C4285900
Disease: Intraventricular dyssynchrony
Intraventricular dyssynchrony
0.010 GeneticVariation disease BEFREE Septal-lateral >60ms delay for the beginning of systolic velocity in TDI and septum-posterior >130ms delay in M-mode were accepted as intraventricular dyssynchrony. 28081851 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.010 GeneticVariation disease BEFREE Among 5801 elderly participants in the ARIC study (Atherosclerosis Risk in Communities; age range, 67-90 years; mean age, 76±5 years; 42% male; 21% black), we determined the continuous association of diastolic measures (tissue Doppler imaging [TDI] e', E/e', and left atrial size) with concomitant N-terminal pro-brain natriuretic peptide and subsequent HF hospitalization or death. 27927714 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 GeneticVariation disease BEFREE Among 5801 elderly participants in the ARIC study (Atherosclerosis Risk in Communities; age range, 67-90 years; mean age, 76±5 years; 42% male; 21% black), we determined the continuous association of diastolic measures (tissue Doppler imaging [TDI] e', E/e', and left atrial size) with concomitant N-terminal pro-brain natriuretic peptide and subsequent HF hospitalization or death. 27927714 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.010 Biomarker group BEFREE In conclusion, TDI (medial E'>6.5 cm/s; lateral E'>7.8 cm/s) appears to predict LVEF recovery in patients with sinus tachycardia upon resolution of the tachycardia in patients with cancer. 27767228 2017
CUI: C0039239
Disease: Sinus Tachycardia
Sinus Tachycardia
0.010 Biomarker disease BEFREE In conclusion, TDI (medial E'>6.5 cm/s; lateral E'>7.8 cm/s) appears to predict LVEF recovery in patients with sinus tachycardia upon resolution of the tachycardia in patients with cancer. 27767228 2017
CUI: C1168250
Disease: Laryngopharyngeal Reflux
Laryngopharyngeal Reflux
0.010 Biomarker disease BEFREE The odor threshold, odor discrimination, odor identification, and TDI scores of the laryngopharyngeal reflux group were significantly lower than those of the control group. 27472044 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE In conclusion, TDI (medial E'>6.5 cm/s; lateral E'>7.8 cm/s) appears to predict LVEF recovery in patients with sinus tachycardia upon resolution of the tachycardia in patients with cancer. 27767228 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.010 Biomarker disease BEFREE The effect of H4R activation on NK cell migration, NK cell-dendritic cell interaction and cytokine levels in the skin was further characterized in the murine TDI model of allergic dermatitis. 27155791 2016
CUI: C0221757
Disease: alpha 1-Antitrypsin Deficiency
alpha 1-Antitrypsin Deficiency
0.010 Biomarker disease BEFREE The aim of this study was to measure the diameters of the Valsalva sinuses (VS), sinotubular junction (STJ), ascending aorta (AA) and aortic arch (AAr) and elastic properties of the AA (distensibility, stiffness and tissue Doppler imaging (TDI strain)) in AATD subjects. 22851685 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.010 AlteredExpression disease BEFREE TDI scores were analyzed according to complement levels (C1INH, C3, C4 and CH50), Beck depression inventory (BDI-II) and danazol treatment. 20649895 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.010 AlteredExpression disease BEFREE TDI scores were analyzed according to complement levels (C1INH, C3, C4 and CH50), Beck depression inventory (BDI-II) and danazol treatment. 20649895 2011
CUI: C0019243
Disease: Angioedemas, Hereditary
Angioedemas, Hereditary
0.010 GeneticVariation disease BEFREE Thirty patients with HAE and 30 healthy age- and sex-matched controls were evaluated for olfactory functions using the 3-stages Sniffin'-Sticks kit (threshold, discrimination, and identification [TDI]). 20649895 2011
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.010 AlteredExpression phenotype BEFREE TDI scores were analyzed according to complement levels (C1INH, C3, C4 and CH50), Beck depression inventory (BDI-II) and danazol treatment. 20649895 2011
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 Biomarker disease BEFREE We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032). 12411588 2002
Systemic Inflammatory Response Syndrome
0.010 Biomarker disease BEFREE We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032). 12411588 2002
CUI: C0039743
Disease: Thanatophoric Dysplasia
Thanatophoric Dysplasia
0.010 GeneticVariation disease BEFREE The achondroplasia class of chondrodysplasias comprises the most common genetic forms of dwarfism in humans and includes achondroplasia, hypochondroplasia and thanatophoric dysplasia types I and II (TDI and TDII), which are caused by different mutations in a fibroblast growth-factor receptor FGFR3 (ref.1). 9069288 1997
CUI: C0343284
Disease: Chondrodysplasia
Chondrodysplasia
0.010 GeneticVariation disease BEFREE The achondroplasia class of chondrodysplasias comprises the most common genetic forms of dwarfism in humans and includes achondroplasia, hypochondroplasia and thanatophoric dysplasia types I and II (TDI and TDII), which are caused by different mutations in a fibroblast growth-factor receptor FGFR3 (ref.1). 9069288 1997