|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Several ion-channels showed significantly increased expression in tumors (p < 0.0005); nine genes (namely, CACNA1D, FXYD3, FXYD5, HTR3A, KCNE3, KCNE4, KCNN4, CLIC1, TRPM3) showed such significant modification in at least half of datasets investigated for each cancer type.
|
27716384 |
2016 |
|
Neuroleptic Malignant Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and NMS.
|
22987075 |
2012 |
|
Neonatal maladjustment syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A KCNE3 T4A mutation was identified in a Japanese patient presenting Brugada-pattern ECG and NMS.
|
22987075 |
2012 |
|
Tinnitus
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, owing to a lack of power, our study can neither rule out effects of KCNE3 on the risk for developing chronic tinnitus, nor can it exclude a role in predicting the severity of tinnitus.
|
21899751 |
2011 |
|
Meniere Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Six additional SNPs in both KCNE1 and KCNE3 were genotyped and none was associated with MD.
|
20034061 |
2010 |
|
Lone atrial fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
KCNE3 mutation V17M identified in a patient with lone atrial fibrillation.
|
18209471 |
2008 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The findings lend weight to the premise that specific channels, such as MiRP2-Kv3.4, could hold promise as future therapeutic targets in Alzheimer's disease and potentially other neurodegenerative disorders.
|
17595326 |
2007 |
|
Thyroid Gland Follicular Adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No somatic mutation of TSH receptor was found in his thyroid adenoma and no known genetic mutations of ionic channel genes, such as calcium (CACN1S), sodium (SCN4A) and potassium (KCNE3), were found.
|
17917308 |
2007 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The findings lend weight to the premise that specific channels, such as MiRP2-Kv3.4, could hold promise as future therapeutic targets in Alzheimer's disease and potentially other neurodegenerative disorders.
|
17595326 |
2007 |
|
Channelopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Missense mutations in kcne1, kcne2, and kcne3 are linked to congenital and acquired channelopathies in Homo sapiens.
|
17491013 |
2007 |
|
Thyrotoxic periodic paralysis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No pathogenic mutation in KCNE3 was found in the TPP patients.
|
15212652 |
2004 |
|
Hypokalemic periodic paralysis type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis.
|
12414843 |
2002 |
|
Paramyotonia Congenita (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical and electrophysiological data have outlined a spectrum of similar yet distinct periodic paralyses, including potassium-sensitive (hyperkalemic periodic paralysis [HYPP]) and temperature-sensitive (paramyotonia congenita [PC]) forms.
|
8388676 |
1993 |
|
Cardiac Arrhythmia
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Inherited sequence variants in human KCNE1 and KCNE3 cause cardiac arrhythmias but by different mechanisms, and each is important for hearing in unique ways.
|
26410412 |
2016 |
|
Cardiac Arrhythmia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Based on quantitative modeling of a transmural cardiac segment, we demonstrate that the degree of QT interval abbreviation observed results from electrotonic interactions in the face of limited transduction efficiency and that heterogeneous transduction of E3 may actually potentiate arrhythmias.
|
11956246 |
2002 |
|
Atrial Fibrillation
|
0.040 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate if mutations in potassium-channel β-subunits KCNE2 and KCNE3 are associated with early-onset lone AF.
|
24796621 |
2014 |
|
Atrial Fibrillation
|
0.040 |
Biomarker
|
disease |
LHGDN |
We suggest abnormalities in the KCNE3 gene as a potential genetic risk factor for initiation and/or maintenance of AF.
|
18209471 |
2008 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We suggest abnormalities in the KCNE3 gene as a potential genetic risk factor for initiation and/or maintenance of AF.
|
18209471 |
2008 |
|
Atrial Fibrillation
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Mutation screening of the KCNQ1, KCNE1, KCNE2, and KCNE3 genes was performed in 50 families with AF.
|
17276182 |
2007 |
|
Familial Periodic Paralysis
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings identify a key regulatory domain in MiRP2 and suggest a mechanistic link between acidosis and episodes of periodic paralysis.
|
16449802 |
2006 |
|
periodic paralysis (finding)
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings identify a key regulatory domain in MiRP2 and suggest a mechanistic link between acidosis and episodes of periodic paralysis.
|
16449802 |
2006 |
|
Atrial Fibrillation
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
For example, phospholamban, the beta-subunit MinK (KCNE1) and MIRP2 (KCNE3), and the 2-pore potassium channel TWIK-1 were upregulated in AF-VHD compared with SR-VHD, whereas the T-type calcium-channel Cav3.1 and the transient-outward potassium channel Kv4.3 were downregulated.
|
16027256 |
2005 |
|
Familial Periodic Paralysis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Periodic paralysis mutation MiRP2-R83H in controls: Interpretations and general recommendation.
|
15037716 |
2004 |
|
periodic paralysis (finding)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Periodic paralysis mutation MiRP2-R83H in controls: Interpretations and general recommendation.
|
15037716 |
2004 |
|
Familial Periodic Paralysis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These observations weaken the proposal that MiRP2-R83H causes periodic paralysis.
|
14504341 |
2003 |