Psoriasis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Additional findings in the present study were a significant reduction in the C4B*2 allele frequency, a non-significant increase in the Bf*F allele frequency and no difference for Bf or C3 phenotype frequencies in the patients with psoriasis as compared to the controls.
|
2613261 |
1989 |
Psoriasis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The major histocompatibility complex haplotype (supratype), HLA-A2-Cw11-Bw46-C2C-BFS-C4A4-C4B2-DRw8 is purported to be a new high-risk haplotype in Japanese patients with psoriasis.
|
1929549 |
1991 |
Disease of capillaries
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The association of the rare C4B3 variant with microangiopathy suggests a genetic component of its aetiology.
|
3926068 |
1985 |
Disease of capillaries
|
0.020 |
Biomarker
|
group |
BEFREE |
The B3 allotype of the fourth component of complement (C4B3) is associated with microangiopathy.
|
3081112 |
1986 |
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two of four siblings expressed the salt-losing form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) and had identical human lymphocyte antigen (HLA) and complement C4 (fourth component of complement) types (HLA-A3,C4,B35,C4A3,C4BQO,DR1/A2,C-,B18,C4A3, C4BQO,DR6).
|
3007562 |
1986 |
Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that the late-onset and cryptic forms of 21-hydroxylase deficiency are highly associated with the HLA supratype HLA-B14,C4A2,C4B1/2,DR1.
|
3013005 |
1986 |
Complement Component 4a Deficiency
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Instead, most East Asian subjects with C4A deficiency were found to have a recombinant haplotype with bimodular C4-Long and C4-Short genes, encoding C4B1 and C4B96, which was linked to HLA-DRB1*1501.
|
26814708 |
2016 |
Complement Component 4a Deficiency
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A large deletion covering most of the C4A gene and the 21-hydroxylase-A (21-OHA) pseudogene found on the extended haplotype B8-C4AQ0-C4B1-DR3 is estimated to account for approximately two-thirds of C4A deficiency in Caucasian SLE patients.
|
11033017 |
2000 |
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The regulatory sequences flanking the inactive miR-146 promoter were hypermethylated at CpG dinucleotides in the EBV positive Burkitt's lymphoma (BL) cell lines of memory B cell phenotype (Rael and Akata), partially methylated in the mammary carcinoma cell lines C2G6 and C4A3, and completely unmethylated in the nasopharyngeal carcinoma cell line C666-1.
|
23528241 |
2013 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
C4B3 was associated with diabetes, consistent with a diabetes gene telomeric of MHC class II.
|
15858601 |
2005 |
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
C4B3 was associated with diabetes, consistent with a diabetes gene telomeric of MHC class II.
|
15858601 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant variation in HLA, BF, C2 or GLO frequencies was found in non-insulin-dependent diabetes mellitus (NIDDM) patients, but there was a significant decrease in C4B 1 and an increase in C4B 2.
|
3879724 |
1985 |
Immune System Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The metabolism of the C4 allotypes C4A3,B1 and C4A3,BO was studied in five healthy control subjects and six patients with active immunological disease (five with systemic lupus erythematosus and one with rheumatoid arthritis).
|
2530015 |
1989 |
Myasthenia Gravis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The increase is due to the association between MG and the 8.1 ancestral haplotype (HLA A1, Cw7, B8, BfS, C4AQ0, C4B1, DR3, DQw2).
|
1352699 |
1992 |
Parkinson Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type.
|
6538270 |
1984 |
Rheumatic Heart Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering that in this investigation only RHD patients were included, further studies are necessary in order to clarify whether C4A6 is a marker for the cardiac form or for the disease itself.
|
7777829 |
1995 |
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alpha-2-antiplasmin, Complement C4-A and Antithrombin-III were increased in first-onset schizophrenia patients (uncorrected P-values 0.041, 0.036 and 0.013, respectively) and also increased in newborn babies who later develop schizophrenia (P-values 0.0058, 0.013 and 0.044, respectively).
|
29249827 |
2017 |
Silicosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
RFLP analysis of C4 and IGLV genes showed significant association between silicosis and a specific RFLP pattern of C4A3-C4B5 allotype (RR = 2.3, P < 0.05) and that of IGLV 5.3 kb (RR = 0.33, P < 0.003).
|
8093341 |
1993 |
Anterior uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc less than 0.002), especially in HLA B27 positive males.
|
3259571 |
1988 |
Immunoglobulin A deficiency (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nine of 11 patients with C4A deletion had an HLA haplotype consistent with the MHC supratype HLA-A1, Cw7, B8, C4AQ0, C4B1, BfS, DR3 previously found to be associated with IgA deficiency.
|
2573059 |
1989 |
Cyclic neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other C4B3 allotypes in informative families have different Ch phenotypes, and the relationships of these within extended major histocompatibility complex haplotypes are discussed in this paper.
|
3865894 |
1985 |
Deficiency of steroid 21-monooxygenase
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have shown that the late-onset and cryptic forms of 21-hydroxylase deficiency are highly associated with the HLA supratype HLA-B14,C4A2,C4B1/2,DR1.
|
3013005 |
1986 |
Adult Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The regulatory sequences flanking the inactive miR-146 promoter were hypermethylated at CpG dinucleotides in the EBV positive Burkitt's lymphoma (BL) cell lines of memory B cell phenotype (Rael and Akata), partially methylated in the mammary carcinoma cell lines C2G6 and C4A3, and completely unmethylated in the nasopharyngeal carcinoma cell line C666-1.
|
23528241 |
2013 |
Childhood Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The regulatory sequences flanking the inactive miR-146 promoter were hypermethylated at CpG dinucleotides in the EBV positive Burkitt's lymphoma (BL) cell lines of memory B cell phenotype (Rael and Akata), partially methylated in the mammary carcinoma cell lines C2G6 and C4A3, and completely unmethylated in the nasopharyngeal carcinoma cell line C666-1.
|
23528241 |
2013 |
Acute anterior uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was an increased incidence of the C4B2 allotype in patients with anterior uveitis (pc less than 0.002), especially in HLA B27 positive males.
|
3259571 |
1988 |