Idiopathic Pulmonary Fibrosis
|
0.510 |
GeneticVariation
|
disease |
BEFREE |
FAM13A gene polymorphism showed a significant association with the susceptibility to IPF, with severity of lung function impairment and with poor prognosis.
|
28137485 |
2017 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We included three SNPs previously associated with COPD: rs7671167 (FAM13A), rs13180 (IREB2), and rs8034191 (CHRNA 3/5), and four SNPs associated with lung function in a genome-wide association study of general population samples: rs2070600 (AGER), rs11134242 (ADCY2), rs4316710 (THSD4), and rs17096090 (INTS12).
|
22461431 |
2012 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD.
|
28166215 |
2017 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One of three variants, rs2013701, was tested in the endogenous genomic context by CRISPR-based genome editing that confirmed its allele-specific effects on FAM13A expression and on cell proliferation, providing functional characterization for this COPD-associated variant.
|
30079747 |
2019 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD.
|
28166215 |
2017 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lung expression quantitative trait loci (eQTLs) were identified and overlaid onto three COPD susceptibility loci derived from GWAS; 4q31 (HHIP), 4q22 (FAM13A), and 19q13 (RAB4B, EGLN2, MIA, CYP2A6).
|
23936167 |
2013 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results support that FAM13A rs2869967 and XRCC5 rs3821104 are associated with COPD in Chinese Han population.
|
22027142 |
2011 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
|
20173748 |
2010 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Quantitative analysis of lungs and airways with CT in subjects with the chronic obstructive pulmonary disease (COPD) candidate FAM13A gene: case control study for CT quantification in COPD risk gene.
|
24651745 |
2014 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
|
21921092 |
2011 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
|
22080838 |
2012 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
|
20173748 |
2010 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The two most significant single-nucleotide polymorphisms in FAM13A from a previous genome-wide study in non-Hispanics were associated with COPD in Hispanics.
|
25584925 |
2015 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.
|
30940143 |
2019 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
|
24621683 |
2014 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genes HHIP and FAM13A confer a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease.
|
27612410 |
2017 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
|
25241909 |
2014 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further, previous studies involving various ethnic groups have revealed associations between COPD and genetic polymorphisms in families with sequence similarity 13, member A (FAM13A), micro-RNA 2054 (MIR2054), SET domain containing protein 7 (SETD7), ring finger protein 150 (RNF150), hedgehog interacting protein (HHIP), and vascular endothelial growth factor A (VEGFA).
|
26251585 |
2015 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
|
22080838 |
2012 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
|
30804561 |
2019 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cumulative genetic risk score analyses (CGRS), derived by adding risk alleles, revealed that the risk for COPD increased with the growing number of the FAM13A risk alleles.
|
26310313 |
2015 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
|
20173748 |
2010 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
|
25101718 |
2015 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analysis of 6633 individuals with moderate to severe COPD and 5704 control individuals confirmed association at three known loci: CHRNA3 (p=6·38 × 10(-14)), FAM13A (p=1·12 × 10(-14)), and HHIP (p=1·57 × 10(-12)).
|
24621683 |
2014 |
Chronic Obstructive Airway Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether FAM13A polymorphisms would be associated with COPD susceptibility and COPD-related phenotypes in a Chinese Han population.
|
23891779 |
2013 |