Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
PPFIA family members and ALG3 play important roles in tumorigenesis and tumor progression.
|
30805892 |
2019 |
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mRNA expressions of PPFIA family members and ALG3 in laryngeal squamous cell carcinoma cell line and normal laryngeal cell line were detected by quantitative real-time polymerase chain reaction.
|
30805892 |
2019 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
PPFIA family members and ALG3 play important roles in tumorigenesis and tumor progression.
|
30805892 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Based on these findings, PPFIA1 and ALG3 may play roles in oncogene expression in HNSCC.
|
30805892 |
2019 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
ALG3 Is Activated by Heat Shock Factor 2 and Promotes Breast Cancer Growth.
|
29799832 |
2018 |
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The altered level of ALG3 was found corresponding to the drug-resistant phenotype of AML cell lines both in vitro and in vivo.
|
29880818 |
2018 |
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSF2 activated ALG3 and promoted the growth of breast carcinoma.
|
29799832 |
2018 |
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ALG3 at 3q27.1 was higher in ESCCs, especially in patients with lymph node metastasis.
|
24203761 |
2014 |
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ALG3 at 3q27.1 was higher in ESCCs, especially in patients with lymph node metastasis.
|
24203761 |
2014 |
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Congenital disorder of glycosylation type Id: clinical phenotype, molecular analysis, prenatal diagnosis, and glycosylation of fetal proteins.
|
16006436 |
2005 |
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE If
|
0.010 |
Biomarker
|
disease |
BEFREE |
C-II also corrected impaired LLO biosynthesis in cells from a Dolichol (Dol)-P-Man deficient patient (CDG-Ie) and partially corrected LLO in cells from an ALG12 mannosyltransferase-deficient patient (CDG-Ig), whereas cells from an ALG3-deficient patient (CDG-Id) and from an MPDU1-deficient patient (CDG-If) were not corrected.
|
16079417 |
2005 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
We studied the mRNA expressions of PPFIA family members and ALG3 in a variety of tumor types compared with the normal controls using the Oncomine database along with meta-analyses of their expressions in HNSCC cancer cell line.
|
30805892 |
2019 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
We studied the mRNA expressions of PPFIA family members and ALG3 in a variety of tumor types compared with the normal controls using the Oncomine database along with meta-analyses of their expressions in HNSCC cancer cell line.
|
30805892 |
2019 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
We studied the mRNA expressions of PPFIA family members and ALG3 in a variety of tumor types compared with the normal controls using the Oncomine database along with meta-analyses of their expressions in HNSCC cancer cell line.
|
30805892 |
2019 |
Congenital disorder of glycosylation type 1s
|
0.020 |
Biomarker
|
disease |
BEFREE |
ALG3-CDG is one of the very rare types of congenital disorder of glycosylation (CDG) caused by variants in the ER-mannosyltransferase ALG3.
|
31067009 |
2019 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Generally, our data suggest the involvement of hNOT-1/ALG3-1 in various molecular contexts determining essential processes associated with distinct cellular machineries and related to various pathologies, such as cancer, viral infections, neuronal and immunological disorders and CDG.
|
29547901 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The staining intensity of ALG3 was significantly correlated to the tumor grade (grades 2-3 versus 1, p<0.05).
|
29799832 |
2018 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Generally, our data suggest the involvement of hNOT-1/ALG3-1 in various molecular contexts determining essential processes associated with distinct cellular machineries and related to various pathologies, such as cancer, viral infections, neuronal and immunological disorders and CDG.
|
29547901 |
2018 |
Congenital disorder of glycosylation type 1s
|
0.020 |
Biomarker
|
disease |
BEFREE |
ALG3-CDG is very rare, with only nine patients described so far.
|
26126960 |
2015 |
Familial Alzheimer Disease (FAD)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Another, ALG-3, is a mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2.
|
9106304 |
1997 |
Familial Alzheimer Disease (FAD)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3.
|
8940094 |
1996 |
Congenital Disorders of Glycosylation
|
0.060 |
GeneticVariation
|
group |
BEFREE |
We add four new biochemically confirmed variants to the list of ALG3-CDG inducing variants: c.350G>C (p.R117P), c.1263G>A (p.W421*), c.1037A>G (p.N346S), and the intron variant c.296+4A>G.
|
31067009 |
2019 |
Congenital Disorders of Glycosylation
|
0.060 |
Biomarker
|
group |
BEFREE |
Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.
|
29547901 |
2018 |
Congenital Disorders of Glycosylation
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Based on molecular studies, the 27 CDG patients were classified into different subtypes: ALG9-CDG (8 patients, 29.5%), ALG3-CDG (7 patients, 26%), COG6-CDG (7 patients, 26%), MGAT2-CDG (3 patients, 11%), SLC35A2-CDG (1 patient), and PMM2-CDG (1 patient).
|
28742265 |
2017 |
Congenital Disorders of Glycosylation
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Fifteen patients were included: 9 with PMM2-CDG and 6 with non-PMM2-CDG (one ALG3-CDG, one ALG9-CDG, two ALG11-CDG, one MPDU1-CDG and one ATP6V0A2-CDG).
|
28122681 |
2017 |