|
Liver Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Between March 2016 and March 2017, the DNA methylation, and quantification using (epigenetic ELISA kit) for E-cadherin, APC, and P14 genes were studied in three groups of patients: HCV related liver cirrhosis without HCC group (LC-group; n= 20), HCC on top of HCV-related cirrhosis (HCC-group; n= 20), and a third apparently healthy control group (control-group; n= 10).
|
29865038 |
2018 |
|
Mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A majority of mesothelioma lacks p14 and p16 expression, which leads to defective p53 pathway despite bearing the wild-type p53 genotype.
|
29899847 |
2018 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acute myocardial infarction (AMI) was surgically induced in neonatal pigs on postnatal days 1, 2, 3, 7, and 14 (ie, the P1, P2, P3, P7, and P14 groups, respectively).
|
30030418 |
2018 |
|
Clonic Seizures
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, dorsal forebrain-specific GLT1 knockout mice showed nonlethal complex seizures including myoclonic jerks, hyperkinetic running, spasm and clonic convulsion via the activation of NMDA receptors during a limited period from P12 to P14 and selective neuronal death in cortical layer II/III and the hippocampus.
|
29214672 |
2018 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Identification of MMTV-associated p14 proteins in benign breast tissues confirms prior PCR-based studies that MMTV infection occurs before the development of MMTV positive breast cancer.
|
29868468 |
2018 |
|
Cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Between March 2016 and March 2017, the DNA methylation, and quantification using (epigenetic ELISA kit) for E-cadherin, APC, and P14 genes were studied in three groups of patients: HCV related liver cirrhosis without HCC group (LC-group; n= 20), HCC on top of HCV-related cirrhosis (HCC-group; n= 20), and a third apparently healthy control group (control-group; n= 10).
|
29865038 |
2018 |
|
Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of the 24 peptides, P14 (α3<sub>127-148</sub> ) could induce 90.5% (19/21) of WKY rats developing anti-GBM glomerulonephritis with proteinuria, elevated serum urea and creatinine, IgG linear deposit on GBM and substantial (in average 82.4 ± 5.6%) crescent formation in glomeruli.
|
28296059 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, complementation of p14 in the Core-expressing cells by either ectopic expression or treatment with 5-Aza-2'dC almost completely abolished the potential of HCV Core to suppress ATRA-induced apoptosis.
|
29156743 |
2017 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The mistargeted sprouting of CST, and the worse motor outcome of the P14 stroke rats were reversed by an early skilled motor training, underscoring the potential of early activity-dependent plasticity in modulating lesion outcome.
|
28706475 |
2017 |
|
Corneal calcification
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
When used at dosages appropriate for adult animals, ketamine-xylazine anesthetics led to a high rate of respiratory failure, increased apoptotic activity in the corneal epithelium, and irreversible corneal calcification in P14 rat pups.
|
28122088 |
2017 |
|
Respiratory Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When used at dosages appropriate for adult animals, ketamine-xylazine anesthetics led to a high rate of respiratory failure, increased apoptotic activity in the corneal epithelium, and irreversible corneal calcification in P14 rat pups.
|
28122088 |
2017 |
|
Bronchopulmonary Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neonatal mice were subjected to 75% oxygen exposure from postnatal day (P)0 to P14 to model BPD, then allowed to recover in room air for 1 (P15), 7 (P21), or 14 days (P28).
|
27861592 |
2016 |
|
Uterine Cervical Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Human papillomavirus types 16 E1 mRNA is transcribed from P14 early promoter in cervical neoplasms.
|
26655237 |
2016 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWASs) have unequivocally linked the CDKN2A/B locus, which encodes p16 inhibitor of cyclin-dependent kinase (p16(INK4A)) and three other gene products, p14 alternate reading frame (p14(ARF)), p15(INK4B) and antisense non-coding RNA in the INK4 locus (ANRIL), with human diabetes risk.
|
27155872 |
2016 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Genome-wide association studies (GWASs) have unequivocally linked the CDKN2A/B locus, which encodes p16 inhibitor of cyclin-dependent kinase (p16(INK4A)) and three other gene products, p14 alternate reading frame (p14(ARF)), p15(INK4B) and antisense non-coding RNA in the INK4 locus (ANRIL), with human diabetes risk.
|
27155872 |
2016 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28.
|
28214898 |
2016 |
|
Iron deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28.
|
28214898 |
2016 |
|
Tonic clonic movements
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three ictal patterns were identified: from P9 to P12 "spike clusters" consisted of recurring large spikes without clinical correlate; "spasm-like" discharges dominated from P13 to P16 consisting of high amplitude large field potential superimposed with or followed by fast activity repeated every 2-10 s for at least 20 s, accompanied by rhythmic limb contractions; from P14 to P18 a "tonic-clonic like" pattern comprised rhythmic spikes of increasing amplitude with tonic-clonic movements.
|
26873267 |
2016 |
|
Epithelioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Future studies should investigate genetic abnormalities in p14 coding sequences and include all types of ovarian epithelial tumors.
|
27770808 |
2016 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
HBV infection is associated with p14 (ARF) , p15 (INK4B) , p16 (INK4A) , and RB gene methylation (P = 0.048, 0.035, 0.02); HBV-DNA replication is associated with p14 (ARF) , p15 (INK4B) , p16 (INK4A) , and RB gene methylation (P = 0.048, 0.035, 0.02); high rate of p14 (ARF) , p15 (INK4B) , and p16 (INK4A) in HCC with HBV infection suggests that HBV-induced hypermethylation may be one of the mechanisms of HBV involved in hepatocellular carcinogenesis.
|
24254306 |
2014 |
|
Squamous cell carcinoma of oropharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multivariable analysis found that patients with p14 (ARF) -rs3731217 TT genotype had an ~7-, 11- and 3-fold increased risk for death overall, death due to SCCOP and recurrence than those with TG/GG variant genotypes, respectively.
|
24104554 |
2014 |
|
Malignant Squamous Cell Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
The p14 promoter was unmethylated in 86.7 % of OSCC and in 85.7 % of LSCC patients; for the p16 promoter these rates were 69.0 % and 76.2 % for OSCC and LSCC patients, respectively.
|
24710824 |
2014 |
|
Cystitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cystitis was produced by intravesicular injection of zymosan (1% in saline) into the bladder during postnatal (P) days P14 through P16 and spinal dorsal horns (L6-S1) were collected either on P60 (unchallenged groups) or on P30 after a zymosan re-challenge on P29 (re-challenged groups). miRNA arrays and real-time reverse transcription-polymerase chain reaction (RT-PCR) revealed significant, but differential, up-regulation of mature miR-181a in the L6-S1 spinal dorsal horns from zymosan-treated rats compared with saline-treated controls in both the unchallenged and re-challenged groups.
|
23273104 |
2013 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
p14 expression seems to increase initially in early breast cancer and decrease with further tumour progression. p14 may be induced to counteract immortalisation and hTERT surge.
|
23645774 |
2013 |
|
Liposarcoma, Pleomorphic
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The results from the current study suggest significant impact of the p14 (ARF) gene methylation on the pathogenesis and progression of myxoid and to a lesser extent pleomorphic liposarcoma.
|
23918242 |
2013 |