|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin-dependent kinase inhibitor 2A (p16<sup>INK4a</sup>) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC).
|
30333880 |
2018 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unlike the cervix, p16 and cyclin E will not consistently distinguish VSKs from HPV-negative lesions due to underexpression in low-risk HPV infections (p16) and less-restricted expression in vulvar lesions (cyclin E).
|
12827609 |
2003 |
|
Human papilloma virus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated overexpression of p16(INK4a) and HPV infection in cervical squamous neoplasia to evaluate the oncogenic potential among various HPV subtypes.
|
16445657 |
2006 |
|
Human papilloma virus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland.
|
29430168 |
2018 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
RESULTS of the present study indicate that HPV is less likely to cause OSCC in young Japanese patients, and the p16(INK4a) expression level is not an appropriate surrogate marker for HPV infection in OSCC.
|
24935359 |
2014 |
|
Human papilloma virus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pooled results showed no significant relationship between p16INK4a expression and HPV infection in ESCC based on overall HPV types (OR: 1.79, 95% CI: 0.69-4.66, p = 0.235).
|
27229481 |
2016 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
The proxy marker for human papillomavirus (HPV), p16, is included in the new AJCC 8th/UICC 8th staging system, but due to incongruence between p16 status and HPV infection, single biomarker evaluation could lead to misallocation of patients.
|
29795309 |
2018 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
RB protein correlated negatively (P<0.0001) and p16(INK4A) (P<0.0001) and p21 (P=0.0002) correlated positively with HPV infection. p53 did not correlate with HPV infection.
|
21323963 |
2011 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV infection status was tested by HPV E6-targeted multiplex real-time PCR and p16 immunohistochemistry (IHC).
|
26992242 |
2016 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies from Asian countries, have suggested that human papillomavirus (HPV) infection plays a role in the pathogenesis and overexpression of p16(INK4a), a surrogate marker of HPV infection, have also been reported.
|
24440092 |
2014 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, p16 is not a reliable surrogate marker for HPV infection in urothelial inverted papilloma.
|
23681080 |
2013 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Assessing both the expression level of the E6/E7 mRNAs and of CDKN2A in HNSCC is required to detect active HPV infection.
|
19795456 |
2010 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We can conclude that high-risk HPV types are associated with p16 overexpression, and p16 may serve as a biomarker in oral cancer related to high-risk HPV infection.
|
14500697 |
2003 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three out of the four cases (75%) were positive for p16 by immunohistochemistry and the same cases positive for HPV-16 DNA.
|
29954784 |
2018 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV does not play an etiologic role in inverted papilloma or oncocytic papilloma of the sinonasal region. p16 immunostaining should not be used as a surrogate marker to evaluate the HPV infection status in these lesions.
|
31797088 |
2019 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus (HPV) type 16 has also been suggested to play a role in etiology of head and neck squamous cell carcinoma (HNSCC). p16 expression is now being used as a surrogate marker of HPV infection in squamous cell carcinoma and provides important prognostic information and future therapy planning.
|
27072243 |
2016 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, p16 as a surrogate marker for HR-HPV infection in cancers of the oral cavity remains controversial.
|
27644660 |
2016 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of p16 was not found to be a reliable biomarker for HPV infection in patients with OL and OSCC.
|
30842161 |
2019 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of p16 is used as a surrogate marker of HPV infection.
|
24821878 |
2014 |
|
Human papilloma virus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
p16INK4A expression was detected in 86.7% of vaginal SCCs with a strong and diffuse immunostaining in 60% of cases, and also in 73.3% of vulvar SCCs with focal immunoreactivity in 53.3% The association between p16INK4A expression and HPV infection was significant in vaginal SCCs (p=0.001) but not vulvar SCCs (p>0.05).
|
25605180 |
2014 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
While widely used, p16 immunohistochemistry is both a sensitive and a specific surrogate marker for oncogenic HPV infection in OPSCC, but not in OSCC.
|
30238467 |
2019 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPV appears to play an active role in a small subset of laryngeal squamous cell carcinoma. p16(INK4a) can be used as a surrogate marker of transcriptionally active HPV infection; COX-2 expression had no correlation with HPV DNA and/or RNA positivity.
|
24374907 |
2014 |
|
Human papilloma virus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that HPV does not play an indispensable role in the development of urinary bladder inverted papillomas and that overexpression of p16(Ink4a) does not correlate with HPV infection in these tumors.
|
20036459 |
2010 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Positive p16 immunostaining and high-risk human papilloma virus in situ hybridization revealed human papilloma virus infection.
|
28787322 |
2018 |
|
Human papilloma virus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies have reported that p16 protein overexpression qualifies as a surrogate marker identifying an oncogenic human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC).
|
24249631 |
2014 |