|
Feeding difficulties in infancy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Dilated ventricles (finding)
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of immune system physiology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Congenital Dysplasia Of The Hip
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC and APC2 may therefore have comparable functions in development and cancer.
|
10021369 |
1999 |
|
Atrial Premature Complexes
|
0.020 |
Biomarker
|
disease |
BEFREE |
APC and APC2 may therefore have comparable functions in development and cancer.
|
10021369 |
1999 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC2 remained associated with actin filaments after treatment with the actin-disrupting agent, cytochalasin D. These results suggest that APC2 is involved in actin-associated events and could influence cell motility or adhesion through interaction with actin filaments, as well as functioning independently or in cooperation with APC to down-regulate beta-catenin signaling.
|
11691822 |
2001 |
|
Retinoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APC-2 gene was methylated and down regulated in primary RB tumors.
|
25207834 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
APC-2 gene was methylated and down regulated in primary RB tumors.
|
25207834 |
2015 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
APC2 methylation was upregulated (43.93% vs 7.31%, <i>p</i> < 0.05) in tumors compared to adjacent FFPE tissues.
|
30510602 |
2018 |
|
granulosa cell tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
APC2-deficiency in these mice resulted in predisposition to granulosa cell tumour (GCT) formation, accompanied by acute tumour-associated WNT-signalling activation and a histologic pattern and molecular signature seen in human adult GCTs.
|
31291912 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
APC2-deficiency in these mice resulted in predisposition to granulosa cell tumour (GCT) formation, accompanied by acute tumour-associated WNT-signalling activation and a histologic pattern and molecular signature seen in human adult GCTs.
|
31291912 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
APC2, as one of the target genes, was significantly up-regulated by AQB and led to degradation of β-catenin resulting in suppression of Wnt/β-catenin signaling which may contribute to inhibition of tumor growth and metastasis <i>in vitro</i> and in orthotopic breast cancer models.
|
31367244 |
2019 |
|
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among genes showing an expression similar to that obtained with microarray, puromycin-sensitive aminopeptidase and teratocarcinoma-derived growth factor 3 were up-regulated in PPT and in MB, and adenomatous polyposis coli like was down-regulated only in PPT.
|
15627204 |
2005 |
|
Pineal Gland Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among genes showing an expression similar to that obtained with microarray, puromycin-sensitive aminopeptidase and teratocarcinoma-derived growth factor 3 were up-regulated in PPT and in MB, and adenomatous polyposis coli like was down-regulated only in PPT.
|
15627204 |
2005 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors.
|
10551328 |
1999 |
|
Adenocarcinoma of lung (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
Analysis yielded 20 novel genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1.
|
14647414 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis yielded 20 novel genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1.
|
14647414 |
2004 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
APC and APC2 may therefore have comparable functions in development and cancer.
|
10021369 |
1999 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
APC and APC2 may therefore have comparable functions in development and cancer.
|
10021369 |
1999 |
|
Global developmental delay
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay.
|
31585108 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bioinformatics analysis further revealed APC2, a putative tumor suppressor as a potential target of miR-939.
|
25960217 |
2015 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma.
|
31206208 |
2019 |
|
Colorectal Carcinoma
|
0.330 |
Biomarker
|
disease |
BEFREE |
Collectively, the hsa_circ_0009361/miR-582/APC2 network could be employed as a potential therapeutic target for CRC patients.
|
31109967 |
2019 |
|
Malignant neoplasm of breast
|
0.520 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |