|
Adult Non-Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly increased expression of ABIN1/TNIP1 was observed in the "immunosuppressive" monocyte populations of patients with non-Hodgkin lymphoma ex vivo.
|
27129285 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
|
29566793 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Here, Wray and colleagues identify association of the GPX3-TNIP1 locus with ALS using cross-ethnic meta-analyses.
|
28931804 |
2017 |
|
Ankylosing spondylitis
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ankylosing spondylitis
|
0.120 |
Biomarker
|
disease |
BEFREE |
Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13).
|
21339218 |
2011 |
|
Ankylosing spondylitis
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
This study was conducted to clarify the associations of tumor necrosis factor-α induced protein 3 (TNFAIP3) and TNFAIP3-interacting protein 1 (TNIP1) genetic polymorphisms with ankylosing spondylitis (AS) susceptibility.
|
31308453 |
2019 |
|
Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with psoriasis with TT genotype of rs10036748 in TNIP1, with lower BMI, without arthritis will achieve a better response to MTX.
|
31020648 |
2019 |
|
Arthritis, Psoriatic
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis.
|
30552173 |
2019 |
|
Arthritis, Psoriatic
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Arthritis, Psoriatic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis.
|
21623003 |
2011 |
|
Arthritis, Psoriatic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
More recently, analysis of psoriasis genome-wide association studies in a PsA subgroup has also implicated IL23A, TNFAIP3, and TNIP1 genetic variants as conferring risk to PsA.
|
20875338 |
2010 |
|
Arthritis, Psoriatic
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that c-Rel, as a member of the Rel/NF-κB family, is associated with PsA in the context of disease pathways that involve other identified PsA and PsV susceptibility genes including TNIP1, TNFAIP3, and NFκBIA.
|
22170493 |
2012 |
|
Asthma
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
The T allele of rs10036748 in the TNIP1 gene is the minor protective allele for asthma but the minor or major risk allele for systemic lupus erythematosus and systemic sclerosis in non-Hispanic white or Chinese subjects, respectively.
|
22694930 |
2012 |
|
Asthma
|
0.410 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
|
22694930 |
2012 |
|
Asthma
|
0.410 |
Biomarker
|
disease |
CTD_human |
A20-deficient mast cells exacerbate inflammatory responses in vivo.
|
24453940 |
2014 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population.
|
29559739 |
2018 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
BEFREE |
The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis.
|
21750679 |
2011 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
In this review, we emphasize receptor signaling complexes and regulation of cytoplasmic signaling steps downstream of TLR given their association with some of the same autoimmune diseases where TNIP1 has been implicated.
|
30402506 |
2018 |
|
Autoimmune Diseases
|
0.160 |
AlteredExpression
|
group |
BEFREE |
Genetic variants in the region of TNFAIP3 interacting protein 1 (TNIP1) are associated with autoimmune disease and reduced TNIP1 gene expression.
|
31804013 |
2019 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Conversely, stimulation of the pathway may also ameliorate autoimmune diseases in which TNIP1 is a susceptibility gene.
|
27129285 |
2016 |
|
Autoimmune Diseases
|
0.160 |
Biomarker
|
group |
BEFREE |
Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-κB and of IKBKE (IKKε), which is an NF-κB activator.
|
23944604 |
2013 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
GWASCAT |
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
|
23055271 |
2012 |
|
Autoimmune Diseases
|
0.160 |
GeneticVariation
|
group |
BEFREE |
These data confirmed the influence of TNIP1 on an increased susceptibility to SSc and reinforced this locus as a common autoimmunity risk factor.
|
22896740 |
2013 |
|
Autoimmune hepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population.
|
29559739 |
2018 |
|
Behcet Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of extraocular clinical findings, did not reveal an association of the TNIP1 gene polymorphisms with BD or VKH syndrome subgroups.
|
24788730 |
2014 |