|
Sjogren's Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When compared to healthy controls, both Sema3A and Sema7A levels were decreased in SLE and increased in RA; increased Sema3A level and decreased Sema7A level were found in SS.
|
31412748 |
2020 |
|
Glaucoma, Neovascular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Semaphorin 3A level in CRVO group (1.52 ± 1.23 ng/ml) and NVG group (1.67 ± 0.98 ng/ml) were significantly higher than the control group (0.66 ± 0.58 ng/ml; both p < 0.05).
|
30803163 |
2019 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, we used a neuroblastoma cell line to investigate in vitro whether or not Sema3A-Nrp1 signaling exerts a key role on the caffeine-suppressed neuron survival.
|
30362583 |
2019 |
|
Retinal Vein Occlusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Positive correlation of CRT as well as negative correlation of GC-IPL thickness with SEMA3A may suggest a pathological role of SEMA3A in macular oedema and ganglion cell degeneration during RVO.
|
30803163 |
2019 |
|
Lentivirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
SiRNA transfection and lentivirus infection were performed to regulate Sema3A expression.
|
30579864 |
2019 |
|
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that Sema3A promotes apoptosis in leukemia cells by inhibiting expression of NRP-1, and thus, represents a tumor suppressor protein with a role in the pathogenesis of acute leukemia.
|
30378769 |
2019 |
|
Central retinal vein occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SEMA3A level was positively correlated with CRT and CV in both BRVO group (CRTr = 0.6535, p = 0.0082; CVr = 0.5190, p = 0.0474) and CRVO group (CRTr = 0.6270, p = 0.0124; CVr = 0.6898, p = 0.0044).
|
30803163 |
2019 |
|
Mobius Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among 12 truncated protein-coding genes, SEMA3A is known to bind to the MBS-associated PLXND1.
|
31033088 |
2019 |
|
Caffeine related disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Knocking-down Sema3A through transfection with Sema3A-siRNA dramatically decreased the responsiveness of cells to caffeine administration, as well as cell apoptosis.
|
30362583 |
2019 |
|
Macular retinal edema
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate the semophorin 3A (SEMA3A) level in aqueous humor of patients with retinal vein occlusion (RVO) and explore the correlation of SEMA3A with macular oedema and ganglion cell degeneration in RVO.
|
30803163 |
2019 |
|
Venous retinal branch occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SEMA3A level was positively correlated with CRT and CV in both BRVO group (CRTr = 0.6535, p = 0.0082; CVr = 0.5190, p = 0.0474) and CRVO group (CRTr = 0.6270, p = 0.0124; CVr = 0.6898, p = 0.0044).
|
30803163 |
2019 |
|
Constitutional delay of growth and puberty
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic analyses revealed 15 rare heterozygous missense variants in 15 patients with CDGP (25%) in seven different genes (IGSF10, GHSR, CHD7, SPRY4, WDR11, SEMA3A and IL17RD).
|
31726455 |
2019 |
|
Osteoglophonic dwarfism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that SEMA3A level following OGD injury almost doubled than control group, and the negative effects of OGD injury can be improved by blocking SEMA3A expression.
|
30971898 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, we used a neuroblastoma cell line to investigate in vitro whether or not Sema3A-Nrp1 signaling exerts a key role on the caffeine-suppressed neuron survival.
|
30362583 |
2019 |
|
allergic symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
It has been reported that semaphorin 3A (sema3A) could improve allergic symptoms in allergic rhinitis (AR) mice.
|
30597767 |
2019 |
|
Allergic rhinitis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was performed to determine the immunoregulatory effects of sema3A on airway inflammation in an AR mice model.
|
30597767 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the expression of semaphorin 3A (Sema3A) and nerve growth factor receptor (NGFR) p75 in TNBC tissue was significantly upregulated in response to electroacupuncture.
|
31839752 |
2019 |
|
Neointimal hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mouse carotid artery ligation model was established to evaluate Sema3A expression and its role during neointimal hyperplasia in vivo.
|
30579864 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, we used a neuroblastoma cell line to investigate in vitro whether or not Sema3A-Nrp1 signaling exerts a key role on the caffeine-suppressed neuron survival.
|
30362583 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the expression of semaphorin 3A (Sema3A) and nerve growth factor receptor (NGFR) p75 in TNBC tissue was significantly upregulated in response to electroacupuncture.
|
31839752 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sema3A expression was increased in normal tissues relative to NSCLC tissues.
|
30155491 |
2018 |
|
Ehlers-Danlos Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Pathogenic variants in B3GALT6 have also been shown to cause Ehlers-Danlos syndrome spondylodysplastic type (spEDS-B3GALT6) and spondyloepimetaphyseal dysplasia with joint laxity type I (SEMD-JL1).
|
29443383 |
2018 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, BSYSC treatment increased the expressions of LIF, LIFR and Nkx6.2 and reduced Sema3A and NRP-1 in EAE mice on 40 dpi.
|
29428242 |
2018 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By combining bioinformatics and TMA analysis, we discovered that SEMA3A is highly expressed in human GBM specimens compared to non-neoplastic tissues.
|
29129044 |
2018 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Recently, it has been reported that Semaphorin 3A (SEMA3A) expression is up-regulated in the aganglionic colon in Hirschsprung disease (HD) patients, suggesting that increased SEMA3A expression may be a risk factor for HD.
|
29224790 |
2018 |