|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In view of the conflicting reports in the literature concerning c-erb beta-2 gene amplification or protein over-expression (assessed by western blot or immunohistochemistry) and prognosis of breast cancer, studies in which these parameters are correlated individually with prognosis in the same group of patients are needed.
|
1347417 |
1992 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Hypermethylation of RAR-beta(2) gene was inversely associated with histological and nuclear grade of breast cancer.
|
18463976 |
2009 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, PKC Beta II is a tumour suppressor in colon cancer and low levels serve as a predictor for poor survival outcome.
|
26989024 |
2016 |
|
Colon Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We also concluded that chemotherapy enriched to increase TUBB4B level and/or to stabilize microtubule polymerization might more effectively prevent metastasis in colon cancer development.
|
31375012 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Findings revealed upregulation of select transcripts in classes of genes related to the cytoskeleton (Tubb4b), AD (Cav1), cell death (Bcl2), presynaptic (Syngr1), immediate early (Fosb, Arc), G protein signaling (Gabarap, Rgs10), and cholinergic neurotransmission (Chrnb3) in Ts compared to 2N mice, which were normalized with MCS.
|
31120189 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We here used a monoclonal antibody to βII to examine patients with colorectal cancer and found that patients whose tumors over-express βII have a greatly decreased life expectancy which is even shorter in those patients with nuclear βII.
|
30621030 |
2019 |
|
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
|
29498756 |
2018 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis.
|
29498756 |
2018 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we analyzed whether the pro-apoptotic protein PKCδ, and the pro-survival PKCα and βII, were dysregulated in the brain of R6/1 mouse model of Huntington's disease (HD).
|
23896721 |
2014 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Upregulated stromal PKC-βII in biopsies from patients with CLL, acute lymphoblastic leukemia, and mantle cell lymphoma suggests that this pathway may commonly be activated in a variety of hematological malignancies.
|
23328482 |
2013 |
|
Leukoplakia, Oral
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
RAR-beta(2) promoter was methylated in 67, 56, and 53% of HNSCC tumors, HNSCC cell lines, and microdissected oral leukoplakia specimens, respectively.
|
15014026 |
2004 |
|
Childhood asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Beta-2 receptor agonist exposure in the uterus associated with subsequent risk of childhood asthma.
|
28892561 |
2017 |
|
Malignant neoplasm of colon stage IV
|
0.010 |
Biomarker
|
disease |
BEFREE |
TUBB4B Downregulation Is Critical for Increasing Migration of Metastatic Colon Cancer Cells.
|
31375012 |
2019 |
|
Asthma attack
|
0.010 |
Biomarker
|
disease |
BEFREE |
Steroid use during an asthma attack enhances the beta-2 receptor sensitivity, further potentiating lactate production.
|
29914901 |
2018 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, further studies of SLC2A4 and TUBB2C proteins, and these biological processes and pathways may provide potential targets for the diagnosis and treatment of PCa.
|
31422041 |
2019 |
|
Leukemogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results revealed over-expression of specific proteins with well-established links to lymphomagenesis such as TUBB2C (FDR 0.05), UCHL1 (FDR 0.05) and HSP90AB1 (FDR 0.1).
|
25466511 |
2015 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, further studies of SLC2A4 and TUBB2C proteins, and these biological processes and pathways may provide potential targets for the diagnosis and treatment of PCa.
|
31422041 |
2019 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
RAR-beta(2) promoter was methylated in 67, 56, and 53% of HNSCC tumors, HNSCC cell lines, and microdissected oral leukoplakia specimens, respectively.
|
15014026 |
2004 |
|
Ovarian Serous Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fifty-two tumor specimens from 46 patients with ovarian serous adenocarcinoma were immunohistochemically stained for spectrin βII and scored.
|
21328338 |
2012 |
|
Diabetic foot ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers.
|
29440456 |
2018 |
|
Amaurosis congenita of Leber, type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using exome sequencing in a multiplex family and three simplex case subjects with an atypical association of LCA with early-onset hearing loss, we identified two heterozygous mutations affecting Arg391 in β-tubulin 4B isotype-encoding (TUBB4B).
|
29198720 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We here used a monoclonal antibody to βII to examine patients with colorectal cancer and found that patients whose tumors over-express βII have a greatly decreased life expectancy which is even shorter in those patients with nuclear βII.
|
30621030 |
2019 |
|
Drug-Induced Liver Disease
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
|
25231249 |
2015 |
|
Retinal Degeneration
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Reduced visual acuity
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|