|
Virus Diseases
|
0.250 |
Biomarker
|
group |
BEFREE |
Future studies will be required to clarify whether or not the interplay between NF-IL6 and viral infection is responsible for deregulation of the IL-6 gene.
|
1380488 |
1992 |
|
Virus Diseases
|
0.250 |
AlteredExpression
|
group |
BEFREE |
NF-IL6 is shown to recognize the enhancer core sequence of several viruses, suggesting a possible relationship of virus infection and IL-6 expression.
|
1380241 |
1992 |
|
Virus Diseases
|
0.250 |
GeneticVariation
|
group |
BEFREE |
Consistent with these functions, NF-IL6 alone is sufficient to complement an E1A deletion mutant dl312 in viral infection, when expressed at appropriate concentrations.
|
1309887 |
1992 |
|
Virus Diseases
|
0.250 |
Biomarker
|
group |
MGD |
|
|
|
|
Sepsis
|
0.240 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that the transcription factors Stat3 and C/EBPβ synergize to induces the expression of microRNA (miR)-21 and miR-181b to promote MDSC expansion in a mouse model of polymicrobial sepsis that progresses from an early/acute proinflammatory phase to a late/chronic immunosuppressive stage.
|
31078118 |
2019 |
|
Sepsis
|
0.240 |
Biomarker
|
disease |
BEFREE |
Adoptive transfer of C/EBPβ-deficient Gr1<sup>+</sup>CD11b<sup>+</sup> cells from late septic mice exacerbated inflammation in control mice undergoing early sepsis, confirming they were not immunosuppressive.
|
28476751 |
2017 |
|
Sepsis
|
0.240 |
AlteredExpression
|
disease |
BEFREE |
Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression.
|
28934717 |
2017 |
|
Sepsis
|
0.240 |
Biomarker
|
disease |
BEFREE |
Mechanistically, transcription factor Rb phosphorylation supports Stat3 and C/EBPβ accumulation at both miRNA promoters, and C/EBPβ or Stat3 depletion by siRNA in sepsis Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs inhibits miR-21 and miR-181b expression.
|
27430527 |
2017 |
|
Sepsis
|
0.240 |
Biomarker
|
disease |
RGD |
C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle.
|
11792653 |
2002 |
|
Cleidocranial Dysplasia
|
0.210 |
Biomarker
|
disease |
BEFREE |
CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of the mandible in Cebpb deficient mice.
|
24885110 |
2014 |
|
Cleidocranial Dysplasia
|
0.210 |
Biomarker
|
disease |
MGD |
CCAAT/enhancer-binding protein beta (Cebpb) is a key factor of Runx2 expression and our previous study has reported two CCD signs including hyperdontia and elongated coronoid process of the mandible in Cebpb deficient mice.
|
24885110 |
2014 |
|
Cleidocranial Dysplasia
|
0.210 |
Biomarker
|
disease |
MGD |
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
|
17724128 |
2007 |
|
Cleidocranial Dysplasia
|
0.210 |
Biomarker
|
disease |
MGD |
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene.
|
9405372 |
1997 |
|
Cleidocranial Dysplasia
|
0.210 |
Biomarker
|
disease |
MGD |
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
|
7530603 |
1995 |
|
Arbovirus Infections
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, expression of ISG15 and ISG15 conjugation machinery in cancer cells is directly up-regulated by TNF-α via p38 MAPK and JNK pathways through the activation of C/EBPβ binding element in the ISG15 promoter.
|
31428903 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CCAAT/enhancer binding protein β (C/EBPβ) and matrix metalloproteinase 3 (MMP3) are thought to play key roles in cancer invasion and metastasis.
|
30969151 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the signaling mechanisms that activate C/EBPβ in the cancer milieu are poorly defined.
|
30705122 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, regulating the ratio of LAP/LIP may be a novel strategy for targeting CSCs for the treatment of cancer.
|
31042624 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed T1-weighted, gadolinium-enhanced MR images of a retrospective cohort of 647 primary glioblastoma patients diagnosed between 2005-2013, and performed a multivariable Cox regression analysis to adjust the prognostic effect of SVZ involvement for clinical patient- and tumor-related factors.Protein expression patterns of a.o. markers of neural stem cellness (CD133 and GFAP-δ) and (epithelial-) mesenchymal transition (NF-κB, C/EBP-β and STAT3) were determined with immunohistochemistry on tissue microarrays containing 220 of the tumors.
|
31603915 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CCAAT enhancer binding protein β promotes tumor growth and inhibits apoptosis in prostate cancer by methylating estrogen receptor β.
|
29322786 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For in vivo antitumor studies, the tumor growth rate of mice treated with DTX-loaded <sup>D</sup>T7-LIP was significantly inhibited compared to that in mice treated with DTX-loaded <sup>L</sup>T7-LIP and DTX-loaded Tf-LIP.
|
30395963 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The CCAAT/enhancer binding protein β (C/EBPβ) and matrix metalloproteinase 3 (MMP3) are thought to play key roles in cancer invasion and metastasis.
|
30969151 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the signaling mechanisms that activate C/EBPβ in the cancer milieu are poorly defined.
|
30705122 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, regulating the ratio of LAP/LIP may be a novel strategy for targeting CSCs for the treatment of cancer.
|
31042624 |
2019 |