Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The labeling indices (LI) of pRb, p21, p16, and p27 were higher in HCC lesions than in the adjacent noncancerous lesions and normal controls.
|
10385644 |
1999 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2.
|
12883474 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical studies showed that 40 (54%) of 74 HCCs expressed high levels of p27 (>50% of the tumor cells).
|
12960127 |
2003 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There were no statistical differences in normal liver, liver cirrhosis and pericancerous cirrhosis, but the positive rate of p27 kip1 mRNA also significantly decreased in HCC compared to that in the other groups (P = 0.000, chi2 = 16.600).
|
16052694 |
2005 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Integrin beta(1A) upregulates p27 protein amount at the post-translational level in human hepatocellular carcinoma cell line SMMC-7721.
|
16894473 |
2006 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since loss of p16 is closely related to functional inactivation of p27 in HCC, investigating both p16 and p27 may be useful for precise prognostic predictions in individuals with HCC.
|
18350604 |
2008 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings support the potential effectiveness of a PI3K/Akt-resistant phosphorylated form of p27 in hepatocellular carcinoma gene therapy.
|
18662588 |
2008 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cox multi-factor analysis showed that tumor differentiation (P = 0.006), vascular invasion (P = 0.028), TNM stage (P = 0.005), pAkt (P = 0.021), PTEN (P = 0.003), p27 (P = 0.018) and pS6 (P = 0.002) were independent prognosis factors for HCC.
|
19301157 |
2010 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of p27 has been related to reduced severity of tumor grade and recurrence of HCC.
|
19672859 |
2009 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover: an independent prognosticator with potential p27 (Kip1)-independent oncogenic attributes?
|
19866239 |
2010 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A set of 12 miRNAs (including miR-21, miR-221/222, miR-34a, miR-519a, miR-93, miR-96, and let-7c) was linked to disease progression from normal liver through cirrhosis to full-blown HCC. miR-221/222, the most up-regulated miRNAs in tumor samples, are shown to target the CDK inhibitor p27 and to enhance cell growth in vitro.
|
20018759 |
2010 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene therapeutic approaches aimed at PI3K or the pharmacologic inhibitors of PI3K and transduction of mutant p27 (T157A) to down-regulate p-p27 Thr157 expression could be developed for the management of HCC.
|
20108172 |
2011 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The down-regulation of CSN5 was sufficient to interfere with CSN function as evidenced by the accumulation of neddylated Cullin 1 and changes in the protein levels of CSN-controlled substrates SKP2, p53, p27 and nuclear factor-κB, albeit to a different degree depending on the HCC cell line, which could account for the CSN5 knockdown phenotype.
|
21499307 |
2011 |
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that p21 polymorphisms individually or in combination with p27 polymorphisms increases risk of HCC, particularly among HbsAg-positive individuals.
|
23034899 |
2013 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we found that both MIF4GD and p27 were expressed at low levels in HCC tissues compared to non-cancerous tissues, and that low expression levels of MIF4GD and p27 were associated with significantly worse prognosis in HCC patients.
|
24336329 |
2015 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
JAB1 and p27S10 are overexpressed in HCC samples compared with paired normal tissues.
|
24671224 |
2014 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of S-phase kinase-associated protein 2-mediated p27 degradation suppresses tumorigenesis and the progression of hepatocellular carcinoma.
|
25572801 |
2015 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Herein, we have shown that treatment with globular adiponectin (gAcrp) increases p27 but decreases cyclinD1 expression in human hepatoma (HepG2) and breast (MCF-7) cancer cells.
|
26089158 |
2016 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of KDM5B notably inhibits HCC cell proliferation both in vivo and in vitro via arresting the cell cycle at G1/S phase partly through up-regulation of p15 and p27.
|
26911146 |
2016 |
Liver carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Together, our results indicate that the dynamic interplay between O-GlcNAcylation and p27 phosphorylation coordinates and regulates cell proliferation in hepatocellular carcinoma.
|
27175940 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation.
|
27779207 |
2016 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggested NS mediated p27-dependent cell cycle control via inducing nucleolar sequestration and polyubiquitylation of p27 in HCC.
|
27998760 |
2017 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells.
|
28230855 |
2017 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-221 plays a role in promoting tumorigenesis in HCC by inhibiting the expression of p27.
|
31839741 |
2019 |