|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Lack of expression of TIP30 had an association with lymph node metastasis (odds ratio = 3.90, 95% confidence interval: 2.21-6.89) and high tumor node metastasis clinical stage (odds ratio = 2.10, 95% confidence interval: 1.68-2.62).
|
28036326 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that the expression of TIP30/CC3 was inversely associated with axillary lymph node metastasis (P = .0008) and vascular invasion (P = .0016).
|
17097132 |
2007 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Low TIP30 expression levels were found in all 9 cases of small cell lung cancer and in 36.5% (72/197) of non-small cell lung cancer, which were correlated with lymph node metastasis in non-small cell lung cancer and with poor differentiation and advanced stage of tumor cells in squamous cell carcinoma.
|
19349353 |
2009 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
TIP30 is a tumor suppressor whose expression is altered in human liver, prostate, lung, colon, and breast cancers.
|
17440068 |
2007 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest a potential link between the expression of CC3/TIP30 gene and the HER-2/neu oncogene-mediated signal pathway.These findings could not have been predicted from previous experimental studies, and suggest that CC3/TIP30 may play a complex role in breast cancer.
|
15931508 |
2005 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of TIP30/CC3 expression by RNA-mediated interference greatly enhanced breast cancer cell invasion through the extracellular matrix, whereas overexpression of TIP30/CC3 by adenovirus vector suppressed invasion through the extracellular matrix.
|
17097132 |
2007 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, TIP30 may play an important role in the suppression of hepatocarcinogenesis by acting as a tumor suppressor.
|
16799960 |
2006 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
It has been previously demonstrated that the 30-kDa Tat-interacting protein (TIP30) plays an important role in the suppression of hepatocarcinogenesis by acting as a tumor suppressor.
|
18537194 |
2008 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Together, these results demonstrate that the Tip30 gene is a tumor susceptibility gene playing an important role in the suppression of hepatocarcinogenesis.
|
14695192 |
2003 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.030 |
Biomarker
|
disease |
BEFREE |
Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.
|
30099830 |
2018 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.030 |
Biomarker
|
disease |
BEFREE |
Human TIP30 is a cofactor that specifically enhances human immunodeficiency virus-1 (HIV-1) Tat-activated transcription.
|
10892349 |
2000 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.030 |
Biomarker
|
disease |
BEFREE |
To explore the effects of interventional therapy on human immunodeficiency virus (HIV)-1 Tat interactive protein 2/Tat interactive protein 30 (HTATIP2/TIP30), B7-H4 and short-term curative effect in primary hepatocellular carcinoma.
|
30402840 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a superior synergistic activity on the inhibition of tumor growth and modulation of cell proliferation and epithelial markers in the Apc <sup>Min/+</sup> CRC mouse model was explored, based on the expression levels of Ki-67, E-cadherin, β-catenin, and cleaved caspase-3 (CC3) proteins.
|
27837314 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Somatic missense mutations in the TIP30 gene were identified in human CRC tissue specimens.
|
19798571 |
2010 |
|
Multiple Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.
|
19104151 |
2009 |
|
Multiple Sclerosis
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.
|
19104151 |
2009 |
|
Multiple Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this review, we examine the pathophysiological nature of remyelination failure in chronic MS and discuss the role of TIP30 as a novel therapeutic target.
|
19839715 |
2009 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Human immunodeficiency virus Tat-TIP30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines.
|
30099830 |
2018 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the down-regulation of TIP30 promotes metastatic progression of lung cancer, hence it could serve as a potential target for the development of lung cancer therapies.
|
19349353 |
2009 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
TIP30 was a powerful marker in predicting the prognosis of ESCC.
|
25544767 |
2015 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
61.4% (43 of 70) of primary tumors analyzed displayed TIP30 hypermethylation, indicating that this aberrant characteristic is common in ESCC.
|
25312779 |
2014 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
These data provide evidence that TIP30 plays a role in prostate cancer progression and that TIP30 overexpression may promote prostate cancer cell growth and metastasis.
|
18528861 |
2008 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Human TIP30 was initially identified as a candidate metastasis suppressor gene whose expression was down-regulated in human liver, lung, breast, and prostate cancers, and recently the role of this gene was examined in colorectal cancer.
|
19798571 |
2010 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In summary, the decrease in expression of TIP30/CC3 is related to metastasis and may represent a new prognosticator in breast carcinoma.
|
17097132 |
2007 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggest a potential link between the expression of CC3/TIP30 gene and the HER-2/neu oncogene-mediated signal pathway.These findings could not have been predicted from previous experimental studies, and suggest that CC3/TIP30 may play a complex role in breast cancer.
|
15931508 |
2005 |