Osteoporosis, Age-Related
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density.
|
18924182 |
2008 |
Osteoporosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density.
|
18924182 |
2008 |
Osteoporosis, Senile
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density.
|
18924182 |
2008 |
Post-Traumatic Osteoporosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteomic analysis of circulating monocytes in Chinese premenopausal females with extremely discordant bone mineral density.
|
18924182 |
2008 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations.
|
21211798 |
2011 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate a role for the TRiC subunits TCP1 and CCT2, and potentially the entire TRiC complex, in breast cancer and provide rationale for TRiC as a novel therapeutic target in breast cancer.
|
25704758 |
2015 |
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Decreased breast cancer patient survival correlated with genomic alternations in CCTβ and higher levels of the chaperone.
|
27012814 |
2016 |
Leber Congenital Amaurosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability.
|
27645772 |
2016 |
Leber Congenital Amaurosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.
|
29450543 |
2018 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Decreased breast cancer patient survival correlated with genomic alternations in CCTβ and higher levels of the chaperone.
|
27012814 |
2016 |
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate a role for the TRiC subunits TCP1 and CCT2, and potentially the entire TRiC complex, in breast cancer and provide rationale for TRiC as a novel therapeutic target in breast cancer.
|
25704758 |
2015 |
Amaurosis congenita of Leber, type 1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, novel compound heterozygous mutations were identified as LCA-causative in chaperonin-containing TCP-1, subunit 2 (CCT2), a gene that encodes the molecular chaperone protein, CCTβ.
|
27645772 |
2016 |
Amaurosis congenita of Leber, type 1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, a cct2 mutant line of zebrafish was established to investigate the role of CCT2 mutations in LCA in vertebrates.
|
29450543 |
2018 |
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytochrome b-c1 complex subunit 6, beta-actin, dynamin 1, and heat shock cognate 71 were up-regulated in AD+BB group, while a-enolase, stress-induced-phosphoprotein 1, malate dehydrogenase (MDH), MDH 1, and T-complex protein 1 subunit beta were down-regulated, respectively.
|
29781405 |
2020 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The human CRC tissues revealed greater CCT2 expression than did the normal colon tissues, indicating that higher CCT2 expression in tumor tissues from CRC patients reduced their survival rate.
|
31462707 |
2020 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Some of the deregulated proteins such as thioredoxin 2, glutathione S transferase, T complex protein 1 subunit β (tcbp1), heat shock protein 90 and E3 ubiquitin ligase were previously reported to be associated with either diabetes or insulin resistance.
|
28926063 |
2017 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chaperonin-containing t-complex protein-1 subunit β as a possible biomarker for the phase of glomerular hyperfiltration of diabetic nephropathy.
|
25944975 |
2015 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Along with previously reported glioblastoma-associated biomarkers, levels of all eight subunits of the key molecular chaperone, T-complex protein 1 Ring complex (TRiC), are higher in glioblastoma-EVs, including CCT2, CCT3, CCT5, CCT6A, CCT7, and TCP1 (p < 0.00496).
|
30451371 |
2019 |
Huntington Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In contrast (CCG)7(CCT)2 was found in 85% of the HD alleles which represents significant linkage disequilibrium with the HD mutation.
|
7616551 |
1995 |
Hyperglycemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results showed that C cr and the expression of TCP-1β in kidney were significantly higher one week after hyperglycemia development, suggesting that the hyperfiltration state was successfully established in the mice model.
|
25944975 |
2015 |
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Small cell lung cancer (SCLC) stood out as having statistically significant difference in CCT2.
|
29299146 |
2017 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of CCT2 in tumors from lung cancer patients were also associated with decreased survival.
|
29299146 |
2017 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Along with previously reported glioblastoma-associated biomarkers, levels of all eight subunits of the key molecular chaperone, T-complex protein 1 Ring complex (TRiC), are higher in glioblastoma-EVs, including CCT2, CCT3, CCT5, CCT6A, CCT7, and TCP1 (p < 0.00496).
|
30451371 |
2019 |
Metastatic non-small cell lung cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed a compound that disrupted the interaction of CCT-β with β-tubulin killed a highly metastatic non-small cell lung cancer cell line CL1-5 through inducing ER-stress and caspases activation.
|
31400757 |
2019 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Along with previously reported glioblastoma-associated biomarkers, levels of all eight subunits of the key molecular chaperone, T-complex protein 1 Ring complex (TRiC), are higher in glioblastoma-EVs, including CCT2, CCT3, CCT5, CCT6A, CCT7, and TCP1 (p < 0.00496).
|
30451371 |
2019 |