|
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified CXCR6 as a marker for synovial Tc17 cells, and increased levels of CXCR6 ligand CXCL16 levels in PsA SF (p=0.0005), which may contribute to their retention in the joint.
|
31677365 |
2020 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
However, whether CXCL16 and CXCR6 are also involved in the pathogenesis of ILD, as well as their regulatory role in pulmonary fibrosis, has not been reported.
|
31753588 |
2020 |
|
Chronic heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications.
|
31785110 |
2020 |
|
Bulimia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor expressed by β-cells that has recently been proposed as a potential target for improving glycemic control and suppressing binge eating behaviors.
|
30670596 |
2019 |
|
Developmental Disabilities
|
0.010 |
Biomarker
|
group |
BEFREE |
In this Review, we highlight central mechanisms by which primary cilia coordinate HH, G protein-coupled receptor, WNT, receptor tyrosine kinase and transforming growth factor-β (TGFβ)/bone morphogenetic protein (BMP) signalling and illustrate how defects in the balanced output of ciliary signalling events are coupled to developmental disorders and disease progression.
|
30733609 |
2019 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
As part of the G-protein coupled receptor (GPCR) family, metabotropic glutamate (mGlu) receptors play an important role as drug targets of cognitive diseases.
|
31132237 |
2019 |
|
Diarrhea
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that despite their decreased numbers, lung CXCR6-deficient ILC2 are even more activated cells producing large amount of type 2 cytokines that could drive eosinophilia.
|
31690060 |
2019 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GPR68 (or ovarian cancer G protein-coupled receptor 1, OGR1) is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions.
|
30696114 |
2019 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
Natural killer T (NKT) cells carrying the chemokine receptor CXCR6 participate in liver inflammation and injury responses.
|
30476545 |
2019 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both CXCR3 and CCR2 were overexpressed on HCV-specific CD8+CCR7+CD45RO+ (central memory) cells, whereas effector memory (CD8+CCR7-CD45RO+) cells expressed more CXCR6.
|
30496498 |
2019 |
|
Hypoparathyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
The parathyroid hormone receptor-1 (PTH1R) is a class B G protein-coupled receptor central to calcium homeostasis and a therapeutic target for osteoporosis and hypoparathyroidism.
|
30975883 |
2019 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
CXCR6-Deficiency Improves the Control of Pulmonary <i>Mycobacterium tuberculosis</i> and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs.
|
30899256 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CXCR6 (CD186), known to be closely associated with iNKT cells migration from the periphery to the liver, was highly expressed on peripheral iNKT cells in HBV-LC patients.
|
31069827 |
2019 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor type 5 (mGluR<sub>5</sub>), a prototypical class C G protein-coupled receptor (GPCR), have shown therapeutic potential for various neurological disorders.
|
31025859 |
2019 |
|
Pituitary Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Kisspeptins are peptide products of Kiss1 gene that control the hypothalamic pituitary (HPG) axis by acting via G protein-coupled receptor known as GPR54.
|
30993114 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Maintenance of Type 2 Response by CXCR6-Deficient ILC2 in Papain-Induced Lung Inflammation.
|
31690060 |
2019 |
|
polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Transgenic mice (HBUS) that express the epidermal growth factor receptor (EGFR) ligand HBEGF (heparin-binding epidermal growth factor-like growth factor) and a constitutively active G protein-coupled receptor (US28) in intestinal epithelial cells develop serrated polyps in the cecum.
|
31470007 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GPR18, a G protein-coupled receptor (GPCR), is involved in bacterial clearance and survival in microbial sepsis.
|
30503722 |
2019 |
|
Substance Use Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
G protein-coupled receptor heteromers are key players in substance use disorder.
|
30278192 |
2019 |
|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
For example, multifunctional β-arrestin (ARRB) adapter proteins are best known as regulators of G protein-coupled receptor signaling, but their role at other receptors and their physiological importance in the setting of vascular disease are unclear.
|
30586762 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We had previously identified that the co-expression of transmembrane CXCL16 (TM-CXCL16) and its receptor CXCR6 is an independent risk factor for poor survival in patients with diffuse large B-cell lymphoma (DLBCL).
|
31033093 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
C57BL/6J wild-type (WT) mice and CXCR6-deficient mice (Cxcr6<sup>eGfp/eGfp</sup>) were given injections of diethylnitrosamine (DEN) to induce liver cancer and α-galactosylceramide to activate natural killer T (NKT) cells.
|
30710528 |
2019 |
|
Tick fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activity of native tick kinins and peptidomimetics on the cognate target G protein-coupled receptor from the cattle fever tick, Rhipicephalus microplus (Acari: Ixodidae).
|
31794138 |
2019 |