GNA13, G protein subunit alpha 13, 10672

N. diseases: 46; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression disease BEFREE Together, these results demonstrate a key role of GNA13 overexpression in CRC that contributes to malignant behavior in cancer cells, at least in part through stimulating angiogenesis and increasing the levels of the NF-κB-dependent chemokines CXCL1, CXCL2, and CXCL4. 30267476 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.030 AlteredExpression disease BEFREE These studies in prostate cancer cells demonstrate decreased protein expression levels of Gα13 and RhoA upon simultaneous CXCR4/CB2 agonist stimulation. 29330286 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 AlteredExpression disease BEFREE These studies in prostate cancer cells demonstrate decreased protein expression levels of Gα13 and RhoA upon simultaneous CXCR4/CB2 agonist stimulation. 29330286 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE GNA13 has been found overexpressed in various types of cancer, which is related to tumor metastasis and progression. 30267476 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE GNA13 has been found overexpressed in various types of cancer, which is related to tumor metastasis and progression. 30267476 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 AlteredExpression group BEFREE GNA13 has been found overexpressed in various types of cancer, which is related to tumor metastasis and progression. 30267476 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.020 AlteredExpression group BEFREE In this study, we demonstrate that GNA13 is upregulated in many solid tumors and impacts survival and metastases in patients. 29255247 2018
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular 		0.010 AlteredExpression disease BEFREE Thus, GNA13 protein expression was an independent prognostic factor and may affect disease progression in FL. 30307409 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 Biomarker disease BEFREE Using gene-gene interaction network analysis, relevant core genes, including MET, UBB, GNAI3, and GNA13, were shown to hold a potential relationship with the development of OA in cartilage. 29978613 2018
CUI: C0040188
Disease: Tic disorder
Tic disorder 		0.010 Biomarker disease BEFREE Blockade of GNA13 expression, or of select downstream pathways, using small-molecule inhibitors abrogates GNA13-induced TIC phenotypes, rendering cells vulnerable to standard-of-care cytotoxic therapies. 29255247 2018
CUI: C0278076
Disease: Behavioral tic
Behavioral tic 		0.010 Biomarker disease BEFREE Blockade of GNA13 expression, or of select downstream pathways, using small-molecule inhibitors abrogates GNA13-induced TIC phenotypes, rendering cells vulnerable to standard-of-care cytotoxic therapies. 29255247 2018
CUI: C0280803
Disease: Primary central nervous system lymphoma
Primary central nervous system lymphoma 		0.010 GeneticVariation disease BEFREE Mutations of the CD79B gene were associated with an inferior progression-free survival (PFS), and GNA13 gene mutations were associated with a shorter PFS and overall survival (OS) in PCNSL patients (P < .05). 30227305 2018
CUI: C0751688
Disease: Malignant Squamous Cell Neoplasm
Malignant Squamous Cell Neoplasm 		0.010 AlteredExpression disease BEFREE GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. 29255247 2018
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.010 Biomarker disease BEFREE Taken together, these data indicate that GNA13 expression is a potential prognostic biomarker for tumor progression, and that interfering with GNA13-induced signaling provides a novel strategy to block TICs and drug resistance in HNSCCs. 29255247 2018
CUI: C2169806
Disease: recurrent muscle twitches (symptom)
recurrent muscle twitches (symptom) 		0.010 Biomarker phenotype BEFREE Blockade of GNA13 expression, or of select downstream pathways, using small-molecule inhibitors abrogates GNA13-induced TIC phenotypes, rendering cells vulnerable to standard-of-care cytotoxic therapies. 29255247 2018
CUI: C0079744
Disease: Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma 		0.330 AlteredExpression disease BEFREE The sphingosine-1-phosphate (S1P) receptor S1PR2 and its downstream adaptor Gα13 are recurrently mutationally inactivated in the germinal center B-cell subtype of diffuse large B-cell lymphoma (DLBCL) and are silenced by the S1PR2 repressor FOXP1 in the activated B-cell like subtype of the disease. 31648327 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 AlteredExpression phenotype BEFREE GNA13 is up-regulated in many solid tumors, including prostate cancer, where it contributes to tumor initiation, drug resistance, and metastasis. 31636124 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.040 Biomarker phenotype BEFREE To better understand how GNA13 contributes to tumorigenesis and tumor progression, we compared the entire transcriptome of PC3 prostate cancer cells with those cells in which GNA13 expression had been silenced. 31636124 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 Biomarker phenotype BEFREE miRNA-30d serves a critical function in colorectal cancer initiation, progression and invasion via directly targeting the GNA13 gene. 30651791 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression disease BEFREE In addition, miR-30d expression was negatively correlated with the expression of GNA13 in CRC tissues. 30651791 2019
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.030 AlteredExpression disease BEFREE GNA13 is up-regulated in many solid tumors, including prostate cancer, where it contributes to tumor initiation, drug resistance, and metastasis. 31636124 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.030 AlteredExpression disease BEFREE GNA13 is up-regulated in many solid tumors, including prostate cancer, where it contributes to tumor initiation, drug resistance, and metastasis. 31636124 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE To better understand how GNA13 contributes to tumorigenesis and tumor progression, we compared the entire transcriptome of PC3 prostate cancer cells with those cells in which GNA13 expression had been silenced. 31636124 2019
CUI: C0598935
Disease: Tumor Initiation
Tumor Initiation 		0.010 AlteredExpression phenotype BEFREE GNA13 is up-regulated in many solid tumors, including prostate cancer, where it contributes to tumor initiation, drug resistance, and metastasis. 31636124 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.020 Biomarker disease BEFREE The role of genes affected by human evolution marker GNA13 in schizophrenia. 31676466 2020