ADCY1, adenylate cyclase 1, 107

N. diseases: 42; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 GeneticVariation disease BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819 2019
CUI: C0022104
Disease: Irritable Bowel Syndrome
Irritable Bowel Syndrome 		0.010 Biomarker disease BEFREE We found that AC1, a key enzyme for pain-related cortical plasticity, was significantly increased in the ACC in an animal model of irritable bowel syndrome. 31665810 2019
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.010 AlteredExpression phenotype BEFREE Our findings demonstrate that the upregulation of AC1 protein in the cortex may underlie the pathology of chronic visceral pain; and inhibiting AC1 activity may be beneficial for the treatment of visceral pain. 31665810 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 GeneticVariation disease BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819 2019
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 GeneticVariation disease BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819 2019
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 GeneticVariation disease BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819 2019
CUI: C3898222
Disease: mucosal melanoma
mucosal melanoma 		0.010 Biomarker disease BEFREE Mechanistic investigations identified adenylate cyclase 1 (ADCY1) as a direct target of miR-23a-3p in MM, and knockdown of ADCY1 recapitulated all the phenotypic characteristics of miR-23a-3p overexpression. 30867808 2019
CUI: C4545042
Disease: Chronic visceral pain
Chronic visceral pain 		0.010 Biomarker disease BEFREE These results suggest that AC1 may form a positive regulation in the cortex during chronic visceral pain. 31665810 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation disease BEFREE In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. 31839819 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.010 AlteredExpression disease BEFREE Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. 28218269 2017
CUI: C0016667
Disease: Fragile X Syndrome
Fragile X Syndrome 		0.010 Biomarker disease BEFREE These results demonstrate a connection between the elevated Adcy1 translation and abnormal ERK1/2 signalling and behavioural symptoms in FXS. 28218269 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE CCND3, AQP3, PEG10, RAB27B, and ADCY1 might play essential roles in the metastasis process of RAC through pancreatic secretion and cell adhesion molecules pathways. 28028826 2017
CUI: C0149978
Disease: Adenocarcinoma of rectum
Adenocarcinoma of rectum 		0.010 Biomarker disease BEFREE CCND3, AQP3, PEG10, RAB27B, and ADCY1 might play essential roles in the metastasis process of RAC through pancreatic secretion and cell adhesion molecules pathways. 28028826 2017
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		0.010 Biomarker disease BEFREE Studies with AC1 knockout mice suggest that inhibitors of AC1 may be useful for treating pain and opioid dependence. 28223412 2017
CUI: C0751791
Disease: Reflex Epilepsy, Audiogenic
Reflex Epilepsy, Audiogenic 		0.010 Biomarker disease BEFREE Genetic reduction of Adcy1 also ameliorates autism-related symptoms including repetitive behaviour, defective social interaction and audiogenic seizures. 28218269 2017
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.010 Biomarker disease BEFREE We treated 1321N1 astrocytoma cells with a selective β2 adrenergic agonist and a selective Epac activator with and without adenyl cyclase and protein kinase A inhibition. 24714982 2014
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.010 Biomarker disease BEFREE We treated 1321N1 astrocytoma cells with a selective β2 adrenergic agonist and a selective Epac activator with and without adenyl cyclase and protein kinase A inhibition. 24714982 2014
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.010 GeneticVariation disease BEFREE In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression. 23278386 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 GeneticVariation disease BEFREE In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression. 23278386 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 GeneticVariation disease BEFREE In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression. 23278386 2013
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 GeneticVariation phenotype BEFREE In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression. 23278386 2013
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.010 GeneticVariation group BEFREE In this work, we investigated the association of adenylyl cyclase genes (ADCY1-9), which are implicated in both AD and mood disorders, with alcoholism and comorbid depression. 23278386 2013
CUI: C0242292
Disease: McCune-Albright Syndrome
McCune-Albright Syndrome 		0.010 GeneticVariation disease BEFREE The identification of somatic mutations of the Gsalpha gene have shown that MAS is due to a post-zygotic activating mutation of the Gsalpha subunit leading to a mosaic distribution of cells bearing constitutively active adenyl cyclase activity. 12199345 2002
CUI: C0007133
Disease: Carcinoma, Papillary
Carcinoma, Papillary 		0.010 AlteredExpression disease BEFREE Adenyl-cyclase activity in membrane preparations of 10 papillary carcinomas was also determined. 10342361 1999
CUI: C0238463
Disease: Papillary thyroid carcinoma
Papillary thyroid carcinoma 		0.010 AlteredExpression disease BEFREE Adenyl-cyclase activity was normal in the ten papillary thyroid carcinomas we analyzed. 10342361 1999