Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
While some cholesteryl ester transfer protein inhibitors have had their clinical study interrupted because of no or adverse effects on cardiovascular disease, anacetrapib (MK-0859) is being evaluated in Phase III cardiovascular outcomes trials.
|
27852117 |
2017 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.
|
27608031 |
2016 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cholesteryl ester transfer protein (CETP) I405V polymorphism and cardiovascular disease in eastern European Caucasians - a cross-sectional study.
|
27439317 |
2016 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This study investigated the relation between a genetic variant in the CETP gene and measures of insulin resistance and incident T2DM in patients with manifest cardiovascular disease (CVD).
|
26318399 |
2015 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Whether pharmacologic CETP inhibition will reduce the risk of cardiovascular disease is one of the most fascinating and important questions in the field of cardiovascular medicine.
|
24422575 |
2014 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This review discusses the role of HDL-C in atherogenesis as well as the promise of cholesteryl ester transfer protein (CETP) inhibition in CVD prevention.
|
23317399 |
2013 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A lower cholesterol concentration in the HDL fraction in children with a family history of cardiovascular system diseases was determined by polymorphism of the CETP gene.
|
24091356 |
2013 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes.
|
21185205 |
2012 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cholesteryl ester transfer protein (CETP) plays a major role in lipid metabolism, but studies on the association of CETP polymorphisms with risks of cardiovascular disease are inconsistent.
|
23039379 |
2012 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Torcetrapib, an inhibitor of CETP, increased risk of death and ischemic cardiovascular disease of those randomized to the drug, despite improving the lipid profile.
|
23083790 |
2012 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD.
|
21985435 |
2011 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The concept that HDL cholesterol raising through inhibition of CETP may ameliorate CVD risk has been challenged by the failure of the CETP inhibitor, torcetrapib.
|
20645987 |
2011 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thrombospondin-4 (TSP-4), a matricellular protein of vessel walls associated with inflammation, was investigated in terms of CVD risk using multivariable modelling with a well-characterised functional genetic polymorphism of THBS4 (rs1866389" genes_norm="7060">A387P, rs1866389) along with previously demonstrated risk-related functional genetic polymorphisms of CYBA (C242T, rs4673) and CETP (TaqIB, rs708272), and a set of blood markers.
|
22011848 |
2011 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
LPL polymorphism (D9N) predicts cardiovascular disease risk directly and through interaction with CETP polymorphism (TaqIB) in women with high HDL cholesterol and CRP.
|
21146168 |
2011 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A CETP polymorphism improves the diagnostic power of clinical examination in patients with cardiovascular disease.
|
20458649 |
2010 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Further studies are necessary for understanding of the role of CETP in lipid metabolism and the development of novel therapies involving a combination of strategies for treatment of atherosclerosis and cardiovascular disease.
|
18620517 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The CETP B1B1 genotype may influence the susceptibility to CVD in Taiwan.
|
18287799 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Cholesteryl ester transfer protein B1B1 genotype is associated with a parental history of cardiovascular diseases in Taiwanese people.
|
18287799 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis.
|
18518852 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Common variation in the CETP gene and the implications for cardiovascular disease and its treatment: an updated analysis.
|
18518852 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.
|
18243217 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction.
|
18957472 |
2008 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A cholesteryl ester transfer protein (CETP) genotype (V/V homozygosity for I405V, NCBI dbSNP rs5882) has been associated with preservation of cognitive function in old age, in addition to its associations with exceptional longevity and cardiovascular disease.
|
17531380 |
2007 |
Cardiovascular Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previously, the beneficial effect of an advantageous cholesteryl ester transfer protein (CETP-VV) genotype on lipoprotein particle size in association with decreased metabolic and cardiovascular diseases, as well as with better cognitive function, have been demonstrated.
|
17784782 |
2007 |
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Cholesteryl ester transfer protein (CETP) plays a key role in the metabolism of high-density lipoprotein (HDL), a strong, inverse, independent risk factor for cardiovascular disease.
|
17949364 |
2007 |