|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
POLQ overexpression is present in many cancer types and is associated with poor prognosis, including breast cancer regardless of BRCA1 status.
|
30655289 |
2019 |
|
Malignant neoplasm of skin
|
0.070 |
Biomarker
|
disease |
BEFREE |
Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers.
|
30773314 |
2019 |
|
Malignant neoplasm of skin
|
0.070 |
Biomarker
|
disease |
BEFREE |
The crucial role of DNA polymerase eta in protecting against sunlight-induced tumors is evidenced in Xeroderma Pigmentosum Variant (XP-V) patients, who carry mutations in this protein and present increased frequency of skin cancer.
|
30362123 |
2019 |
|
Malignant neoplasm of skin
|
0.070 |
Biomarker
|
disease |
BEFREE |
DNA polymerase eta is one such specialized enzyme whose function is directly associated with casual development of certain skin cancers and chemo-resistance.
|
30535880 |
2019 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
POLQ overexpression is present in many cancer types and is associated with poor prognosis, including breast cancer regardless of BRCA1 status.
|
30655289 |
2019 |
|
Malignant neoplasm of skin
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Defects in DNA polymerase Eta (Polη) cause the sunlight-sensitivity and skin cancer-propensity disorder xeroderma pigmentosum variant.
|
29859927 |
2018 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
POLQ is a member of a cluster of similarly upregulated genes that are strongly correlated with poor clinical outcome for breast cancer, ovarian cancer and other cancer types.
|
27264557 |
2016 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
POLQ is a member of a cluster of similarly upregulated genes that are strongly correlated with poor clinical outcome for breast cancer, ovarian cancer and other cancer types.
|
27264557 |
2016 |
|
Malignant neoplasm of breast
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer.
|
25417172 |
2015 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer.
|
25417172 |
2015 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
We analyzed through case-control study nine SNPs of POLQ in hereditary (HBC) and sporadic (SBC) breast cancer patients using Taqman Real Time PCR assays.
|
25409685 |
2014 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
We analyzed through case-control study nine SNPs of POLQ in hereditary (HBC) and sporadic (SBC) breast cancer patients using Taqman Real Time PCR assays.
|
25409685 |
2014 |
|
Malignant neoplasm of skin
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Deficiencies of DNA polymerase eta-an enzyme mediating replication past UV-induced DNA damage-predispose individuals to xeroderma pigmentosum variant (XPV) and result in a high incidence of skin cancers.
|
21640722 |
2011 |
|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
|
20624954 |
2010 |
|
Malignant neoplasm of breast
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We therefore correlated the clinical outcomes of two retrospective series of patients with early breast cancer with the expression levels of POLQ, as determined by microarray gene expression analysis.
|
20700469 |
2010 |
|
Malignant neoplasm of skin
|
0.070 |
Biomarker
|
disease |
BEFREE |
Structural basis for the suppression of skin cancers by DNA polymerase eta.
|
20577207 |
2010 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
|
20624954 |
2010 |
|
Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We therefore correlated the clinical outcomes of two retrospective series of patients with early breast cancer with the expression levels of POLQ, as determined by microarray gene expression analysis.
|
20700469 |
2010 |
|
Malignant neoplasm of skin
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
A deficiency in DNA polymerase eta due to germ-line mutations in POLH causes the hereditary disease xeroderma pigmentosum variant (XPV), which is characterized by sunlight sensitivity and extreme predisposition to sunlight-induced skin cancer.
|
19564618 |
2009 |
|
Malignant neoplasm of breast
|
0.070 |
Biomarker
|
disease |
BEFREE |
In conclusion, this screen of DNA repair genes implicates PRKDC and POLQ as candidate tumor suppressor genes involved in breast cancer and suggests that inactivating mutations in RAD50 predispose to pancreatic cancer as well as breast cancer.
|
18281469 |
2008 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In conclusion, this screen of DNA repair genes implicates PRKDC and POLQ as candidate tumor suppressor genes involved in breast cancer and suggests that inactivating mutations in RAD50 predispose to pancreatic cancer as well as breast cancer.
|
18281469 |
2008 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
POLQ overexpression is present in many cancer types and is associated with poor prognosis, including breast cancer regardless of BRCA1 status.
|
30655289 |
2019 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
POLQ overexpression is present in many cancer types and is associated with poor prognosis, including breast cancer regardless of BRCA1 status.
|
30655289 |
2019 |
|
Malignant Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
DNA polymerase η mutational signatures are found in a variety of different types of cancer.
|
29139326 |
2018 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
A substantial excess of single and tandem somatic mutations within known pol η mutable motifs was noted in skin cancer as well as in many other types of human cancer, suggesting that somatic mutations in A:T bases generated by DNA polymerase η are a common feature of tumorigenesis.
|
29139326 |
2018 |