|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of GIPC/Synectin led to a significant inhibition of pancreatic adenocarcinoma growth in an orthotopic mouse model.
|
19509165 |
2009 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GLUT1CBP is also expressed in primary cultures of neurons and astrocytes, as well as in Chinese hamster ovary, 3T3-L1, Madin-Darby canine kidney, Caco-2, and pheochromocytoma-12 cell lines.
|
10198040 |
1999 |
|
Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Main AEs were: stomatitis (11.2%), non-infectious pneumonitis - NIP (3.8%), anaemia (3.8%) and fatigue (3.2%).
|
28711793 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, neuropilin and/or GIPC1 silencing may inhibit PDAC growth.
|
31664117 |
2019 |
|
Bradyarrhythmia (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is interesting to note that the selective I<sub>KACh</sub> channel blocker NIP-151 repressed the increased current and improved bradyarrhythmia phenotypes in the mutant zebrafish.
|
30764634 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
GIPC/Synectin has been shown to be overexpressed in pancreatic and breast cancer.
|
19509165 |
2009 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Moreover, we showed that wild-type p53 reduced GIPC-induced breast cancer cell survival, whereas mutant p53 inhibited GIPC-induced cell invasion.
|
21047775 |
2010 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis.
|
21209904 |
2010 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Therefore, GIPC1, GIPC2 and GIPC3 might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion.
|
12011974 |
2002 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GIPC1 mRNA was relatively highly expressed in gastric cancer cell lines OKAJIMA, TMK1, MKN28, MKN45, MKN74, KATO-III, pancreatic cancer cell line AsPC-1, colorectal cancer cell line SW480, and lung cancer cell line A549.
|
11956658 |
2002 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, a GIPC1 knock-down gene signature was used to interrogate publically available breast and ovarian cancer microarray datasets.
|
21209904 |
2010 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GIPC1 upregulation in breast, ovarian and pancreatic cancers promotes tumor proliferation and invasion, whereas GIPC1 downregulation in cervical cancer with human papillomavirus type 18 infection leads to resistance to cytostatic transforming growth factorβ signaling.
|
23743496 |
2013 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GIPC1 upregulation in breast, ovarian and pancreatic cancers promotes tumor proliferation and invasion, whereas GIPC1 downregulation in cervical cancer with human papillomavirus type 18 infection leads to resistance to cytostatic transforming growth factorβ signaling.
|
23743496 |
2013 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, GIPC1 mRNA was almost undetectable in leukemia/lymphoma cell lines HL-60, Raji, and Daudi.
|
11956658 |
2002 |
|
Colorectal Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
To better understand GIPC1 function, we suppressed its expression in human breast and colorectal cancer cell lines and human mammary epithelial cells (HMECs) and assayed both gene expression and cellular phenotype.
|
21209904 |
2010 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This is the first report on molecular cloning of GIPC2, the second member of the GIPC gene family, which is down-regulated in human primary kidney and colorectal tumors.
|
11836570 |
2002 |
|
Congenital deafness
|
0.010 |
Biomarker
|
disease |
BEFREE |
As GIPC proteins are involved in trafficking, signaling and recycling of RTKs, GPCRs, integrins and other transmembrane proteins, dysregulation of GIPCs results in human pathologies, such as cancer and hereditary deafness.
|
23743496 |
2013 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
For example, the inferred structurally important role of the PDZ domain-containing protein GIPC1 in diabetes is supported despite the lack of this information in the Online Mendelian Inheritance in Man database.
|
22034985 |
2011 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
For example, the inferred structurally important role of the PDZ domain-containing protein GIPC1 in diabetes is supported despite the lack of this information in the Online Mendelian Inheritance in Man database.
|
22034985 |
2011 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Main AEs were: stomatitis (11.2%), non-infectious pneumonitis - NIP (3.8%), anaemia (3.8%) and fatigue (3.2%).
|
28711793 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previously, we found that NRP-1 and its downstream NRP-1/GIPC1 pathway played an important role in GBM.
|
29457830 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrated that NRP-1/GIPC1 pathway plays a vital role in glioma progression, and it is a potential important target for multi-gene combined therapeutics.
|
27481513 |
2016 |
|
hearing impairment
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Haploinsufficiency of GIPC1 may contribute to hearing impairment for its interaction with myosin VI.
|
20648052 |
2010 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Suppression of GIPC1 in human pancreatic cancer cells inhibits in vivo tumor growth in immunodeficient mice.
|
21209904 |
2010 |
|
Infectious pneumonitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Main AEs were: stomatitis (11.2%), non-infectious pneumonitis - NIP (3.8%), anaemia (3.8%) and fatigue (3.2%).
|
28711793 |
2017 |