NCKAP1, NCK associated protein 1, 10787

N. diseases: 28; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE Clostridium difficile infections in a Canadian tertiary care hospital before and during a regional epidemic associated with the BI/NAP1/027 strain. 18573937 2008
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Clostridium difficile strains belonging to the PCR ribotype 027, pulse-field gel electrophoresis (PFGE) type NAP1, toxinotype III and restriction endonuclease analysis group BI harbouring mutations in the tcdC gene and possessing binary toxin components A and B have been described to cause epidemics with increased morbidity and mortality. 19664132 2009
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) has been increasing in incidence and severity in recent years, coincident with the spread of a "hypervirulent" strain, REA type BI (ribotype 027, PFGE NAP 1). 19755166 2009
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027. 24973628 2014
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Clostridium difficile NAP1/ribotype 027 is associated with severe disease and high mortality rates. 25915544 2015
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 GeneticVariation disease BEFREE Clostridium difficile infections (CDI), particularly those caused by the BI/NAP1/027 epidemic strains, are challenging to treat. 30004695 2018
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078. 30052178 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 AlteredExpression disease BEFREE Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients. 30867003 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 AlteredExpression phenotype BEFREE Nck-associated protein 1 (NAP1/NCKAP1) is highly expressed in primary non-small-cell lung cancer (NSCLC) when compared with adjacent normal lung tissues, and its expression levels are strongly associated with the histologic tumor grade, metastasis and poor survival rate of NSCLC patients. 30867003 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE NCKAP1 has been known to promote the malignancy of cancer cells by disrupting the structural stability of WAS protein family member 1 (WASF1) and is correlated with poor prognosis of patients in several cancer types. 31068575 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 Biomarker group BEFREE NCKAP1 has been known to promote the malignancy of cancer cells by disrupting the structural stability of WAS protein family member 1 (WASF1) and is correlated with poor prognosis of patients in several cancer types. 31068575 2019
CUI: C0343386
Disease: Clostridium difficile infection
Clostridium difficile infection 		0.100 Biomarker disease BEFREE An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months. 28501926 2017
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 Biomarker disease BEFREE An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months. 28501926 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 Biomarker group BEFREE As a result, clinicopathological correlations and results from in vivo and in vitro models indicated that NCKAP1 was a tumor suppressor gene. 31068575 2019
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Association of relapse of Clostridium difficile disease with BI/NAP1/027. 23052318 2012
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 Biomarker disease BEFREE Based on these results, the possible role of human Nap1 in AD is discussed. 10673335 2000
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027. 26511742 2016
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) has been increasing in incidence and severity in recent years, coincident with the spread of a "hypervirulent" strain, REA type BI (ribotype 027, PFGE NAP 1). 19755166 2009
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 GeneticVariation disease BEFREE Clostridium difficile infection (CDI) is an increasing cause of nosocomial diarrhoea worldwide, which has been partly attributed to the emergence of hypervirulent strains including C. difficile BI/NAP1/ribotype 027 and BK/NAP7/ribotype 078. 30052178 2018
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
CUI: C0687720
Disease: Central Diabetes Insipidus
Central Diabetes Insipidus 		0.100 GeneticVariation disease BEFREE Colonized patients contribute to transmission, but CDI cases are more likely linked to other infected patients than colonized patients in this cohort with high rates of the NAP1/027/ST1 strain, highlighting the importance of local prevalence of virulent strains in determining transmission dynamics. 29846557 2019
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent.Mutants can appear more virulent. 26946361 2016
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Comparison of Multilocus Sequence Typing and the Xpert C. difficile/Epi Assay for Identification of Clostridium difficile 027/NAP1/BI. 26699700 2016
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains. 28125650 2017
CUI: C1411966
Disease: Clostridium; difficile (disorder)
Clostridium; difficile (disorder) 		0.100 Biomarker disease BEFREE Diversity of multidrug-resistant epidemic Clostridium difficile NAP1/RT027/ST01 strains in tertiary hospitals from Honduras. 29890209 2018