|
Sleep Apnea, Obstructive
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum heparanase levels were found to be significantly associated with apnea hypopnea index (AHI) (r = .57, P < .001) and FMD (r= -.37, P < .001) in patients with OSAS.
|
29087043 |
2018 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Herein we aimed to investigate the relationships between OSAS, heparanase and endothelial dysfunction.
|
29087043 |
2018 |
|
Signet-ring cell adenocarcinoma gastric
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of HPSE mRNA and protein was found in the tumor and in ascites of SRCA as well as in KATO-III cell line.
|
30333909 |
2018 |
|
Prosthetic Valve Thrombosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Baseline heparanase levels were significantly higher in obstructive PVT patients.
|
30273810 |
2018 |
|
Severe Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Day 1 heparanase procoagulant activity ≥350 ng/mL yielded a negative predictive value for severe sepsis of 89%.
|
29120525 |
2018 |
|
malignant neoplasm of breast stage I
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival.
|
29464068 |
2018 |
|
Early-Stage Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, heparanase levels can assist in the diagnosis and in determining the necessity and type of treatment in early stage breast cancer.
|
29464068 |
2018 |
|
Anatomic Stage I Breast Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival.
|
29464068 |
2018 |
|
Prognostic Stage I Breast Cancer AJCC v8
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found that in stage I breast cancer patients strong heparanase staining is associated with shorter overall survival.
|
29464068 |
2018 |
|
Peripheral Nervous System Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore the inhibition of Hpse positively regulates transcription of genes associated with peripheral neuropathies and Schwann cell de-differentiation.
|
29581478 |
2018 |
|
Metastatic Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of heparanase expression in primary and metastatic breast carcinoma.
|
29464068 |
2018 |
|
Apnea+hypopnea
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum heparanase levels were found to be significantly associated with apnea hypopnea index (AHI) (r = .57, P < .001) and FMD (r= -.37, P < .001) in patients with OSAS.
|
29087043 |
2018 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heparanase, therefore, emerges as a potential new target in AP, and heparanase inhibitors, now in phase I/II clinical trials in cancer patients, are hoped to prove beneficial also in AP.
|
28386074 |
2017 |
|
Diabetic Angiopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, C-domain of HPA may have a key role in diabetic vascular complication-associated inflammatory response.
|
28810553 |
2017 |
|
Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess the significance of heparanase in the pathogenesis of particular glomerulonephritis types.
|
27091112 |
2017 |
|
Focal glomerulosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The evaluation of heparanase activity in serum, urine, and granulocytes and superoxide dismutase (SOD) activity in granulocytes of patients with lupus nephritis (n = 17), membranous nephropathy (n = 11), IgA nephropathy (n = 12), focal and segmental glomerulosclerosis (n = 18), mesangiocapillary glomerulonephritis (n = 12) and in 19 healthy volunteers were performed.
|
27091112 |
2017 |
|
Keratoconus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Heparanase transcription was detected in stromal and epithelial cells and appeared upregulated in keratoconus.
|
29379222 |
2017 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increase in heparanase activity without changes in superoxide dismutase activity in the granulocytes from patients with lupus nephritis and membranous nephropathy was observed.
|
27091112 |
2017 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Insulin signaling is regarded as a major contributor to this phenomenon; much less is known about the role of heparan sulfate-degrading enzyme heparanase in the link between metabolic disorders and cancer.In the present study we analyzed clinical samples of breast carcinoma derived from diabetic/non-diabetic patients, and investigated effects of heparanase on insulin signaling in breast carcinoma cell lines, as well as insulin-driven growth of breast tumor cells.We demonstrate that heparanase activity leads to enhanced insulin signaling and activation of downstream tumor-promoting pathways in breast carcinoma cells.
|
28038446 |
2017 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this review, we will briefly summarize what is known about heparanase roles in the CNS, and speculate as to its potential role in regulating disease progression in MS and its animal model EAE (experimental autoimmune encephalitis), which may justify testing of heparanase inhibitors for MS treatment.
|
28778449 |
2017 |
|
Neoplasms, Experimental
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this review, we summarized preclinical studies in experimental tumor models of the main chemical classes of Sulf-2 and heparanase inhibitors.
|
28215163 |
2017 |
|
polyps
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Utilizing the APC Min<sup>+/-</sup> mouse model, we show that heparanase expression and activity are increased in small bowel polyps, whereas polyp initiation and growth were significantly inhibited by PG545, again accompanied by a prominent induction of p21 levels.
|
28147305 |
2017 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that heparanase plays an important role in mediating the neuroinflammatory response after SAH and contributes to SAH-related neurological deficits and early brain injury following SAH.
|
28720149 |
2017 |
|
Teratoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Embryonic stem (ES) cells overexpressing HPSE (Hpse-Tg) proliferated more rapidly than WT ES cells in culture and formed larger teratomas in vivo.
|
27890389 |
2017 |
|
Idiopathic Membranous Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.
|
27091112 |
2017 |