NMU, neuromedin U, 10874

N. diseases: 68; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.020 AlteredExpression disease BEFREE We further examined the expression of NMU and NMU receptor 2 (NMUR2) in NAc and the dorsal striatum of high compared with low alcohol-consuming rats, as this area is of importance in the maintenance of alcohol use disorder (AUD). 31069918 2019
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.020 Biomarker group BEFREE On the other hand, the anorexigenic peptides GLP-1, amylin and NMU independently inhibits reward from alcohol and drugs of abuse in rodents. 30439457 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Functional studies showed that knockdown of NmU reduced cell migration and invasion of CRC cells that overexpressed LINC01555. 31144675 2019
CUI: C0003123
Disease: Anorexia
Anorexia 		0.020 Biomarker disease BEFREE Neuromedin U (NmU) may be a novel target for obesity treatment owing to its anorectic and energy expenditure enhancing effects. 29057457 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.020 Biomarker disease BEFREE Collectively, these results indicated that NMU may confer alectinib resistance in NSCLC. 30096454 2018
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.020 Biomarker group BEFREE Recent findings have shown the neuropeptide neuromedin U (NMU) and its receptor NMU receptor 2 (NMUR2) decrease drug-related behaviors, but it is unknown if substances of abuse alter NMU or NMUR2 expression. 30483076 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U. 29107108 2018
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.020 Biomarker disease BEFREE Given that AUD is a major health-care challenge causing an enormous cost to society and novel treatment strategies are warranted, our data suggest that NMU analogues deserve to be evaluated as novel treatment of AUD in humans. 26769653 2017
CUI: C0003123
Disease: Anorexia
Anorexia 		0.020 Biomarker disease BEFREE The PEGylated NMU-8 showed potent and robust anorectic activity and anti-obesity effect in diet-induced obesity (DIO) mice by once-daily subcutaneous (s.c.) administration. 28400225 2017
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.020 Biomarker disease BEFREE Follow-up functional analyses showed that these SNPs were associated with the expression of EGFR, which encodes the TKI target, and with a nearby gene neuromedin-U, which encodes a G protein-coupled receptor ligand known to be involved in the progression of NSCLC. 27669169 2017
CUI: C1960398
Disease: HER2-positive carcinoma of breast
HER2-positive carcinoma of breast 		0.020 AlteredExpression disease BEFREE Investigating this, here we found that ectopic over-expression of NmU in HER2-positive breast cancer cells induced aberrant metabolism, with increased glycolysis, likely due to enhanced pyruvate dehydrogenase kinase activity. 28340506 2017
CUI: C1960398
Disease: HER2-positive carcinoma of breast
HER2-positive carcinoma of breast 		0.020 Biomarker disease BEFREE Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family- plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients. 29209569 2017
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.020 Biomarker disease BEFREE The aim of the present study was to analyze the significance of Nmu in the regional metastasis of HNSCC. 27279246 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE NMU (Neuromedin U) is a neuropeptide that has been implicated in energy homeostasis and tumour progression. 21791076 2011
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Here we evaluated whether NMU is regulated by RhoGDI2 and is functionally important in tumor progression. 16878152 2007
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.020 Biomarker disease BEFREE We identified 12 novel methylated genes in HNSCC cell lines, including PGP9.5, cyclin A1, G0S2, bone-morphogenetic protein 2A, MT1G, and neuromedin U, which showed frequent promoter hypermethylation in primary HNSCC (60%, 45%, 35%, 25%, 25%, and 20%, respectively). 15342377 2004
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.030 Biomarker disease BEFREE In vivo administration of NMU triggered potent type 2 cytokine responses characterized by ILC2 activation, proliferation and eosinophil recruitment that was associated with accelerated expulsion of the gastrointestinal nematode Nippostrongylus brasiliensis or induction of lung inflammation. 28869965 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.030 Biomarker disease BEFREE The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. 28902842 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.030 Biomarker disease BEFREE Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. 29143821 2017
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.030 GeneticVariation disease BEFREE From a large European multi-center study on childhood obesity, 4,528 children (2.0-9.9 years, mean age 6.0±1.8 SD; boys 52.2%) were randomly selected, stratifying by age, sex and country, and genotyped for tag single nucleotide polymorphisms (SNPs; rs6827359, T:C; rs12500837, T:C; rs9999653,C:T) of NMU gene, then haplotypes were inferred. 28235053 2017
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.030 Biomarker disease BEFREE Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. 29143821 2017
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.030 Biomarker disease BEFREE The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. 28902842 2017
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.030 Biomarker disease BEFREE In vivo administration of NMU triggered potent type 2 cytokine responses characterized by ILC2 activation, proliferation and eosinophil recruitment that was associated with accelerated expulsion of the gastrointestinal nematode Nippostrongylus brasiliensis or induction of lung inflammation. 28869965 2017
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.030 GeneticVariation disease BEFREE Compared with NMU-25, NMS had a significantly reduced maximum response in saphenous vein, and the Arg165Trp variant of NMU-25, associated with childhood-onset obesity, was without effect. 18987052 2009
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.030 GeneticVariation disease BEFREE The rare NMU Arg165Trp variant cosegregated with childhood obesity in a Czech family. 16984985 2006