Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary 		0.010 Biomarker group BEFREE PRL-3, a protein tyrosine phosphatase, was identified in a cDNA library from an explanted human heart obtained from a patient with idiopathic cardiomyopathy. 11355880 2001
CUI: C1658953
Disease: tumor vasculature
tumor vasculature 		0.010 AlteredExpression phenotype BEFREE PRL-3 is also expressed in tumor vasculature, regardless of the tumor source. 14654542 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE PRL-3 is also expressed in tumor vasculature, regardless of the tumor source. 14654542 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 AlteredExpression disease BEFREE PRL-3 mRNA expression was elevated in nearly all metastatic lesions derived from CRCs, regardless of the site of metastasis (liver, lung, brain, or ovary). 14654542 2003
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE PRL-3 mRNA expression was elevated in nearly all metastatic lesions derived from CRCs, regardless of the site of metastasis (liver, lung, brain, or ovary). 14654542 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE PRL-3 mRNA levels were determined in several normal human endothelial cells exposed or unexposed to the phorbol ester phorbol 12-myristate 13-acetate (PMA) and in 27 human tumor cell lines. 16505094 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE PRL-3 is amplified and its message is up-regulated in colorectal carcinoma metastases. 16540666 2006
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.070 AlteredExpression group BEFREE PRL-3 is amplified and its message is up-regulated in colorectal carcinoma metastases. 16540666 2006
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation. 17192274 2007
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.100 Biomarker disease BEFREE PRL-3 might be a novel molecular marker for aggressive gastric cancer. 17235563 2007
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE PRL-3 might be a novel molecular marker for aggressive gastric cancer. 17235563 2007
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.100 Biomarker disease BEFREE PRL-3 plays a key role in the control of gastric cancer growth. 19009246 2009
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE PRL-3 plays a key role in the control of gastric cancer growth. 19009246 2009
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.020 AlteredExpression disease BEFREE PRL-3 expression in NSCLC was high, and this over-expression is correlated with advanced clinical stage (p = 0.019), distant metastasis (p = 0.001), lymph node metastasis (p = 0.001), and poor post-operative survival. 19152186 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE PRL-3 expression in NSCLC was high, and this over-expression is correlated with advanced clinical stage (p = 0.019), distant metastasis (p = 0.001), lymph node metastasis (p = 0.001), and poor post-operative survival. 19152186 2009
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE PRL-3 induces microvascular and lymphatic vessel formation by facilitating VEGF and VEGF-C expression in lung cancer tissues, thus promoting distant and lymph node metastasis of lung cancer. 19152186 2009
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 AlteredExpression disease BEFREE PRL-3 induces microvascular and lymphatic vessel formation by facilitating VEGF and VEGF-C expression in lung cancer tissues, thus promoting distant and lymph node metastasis of lung cancer. 19152186 2009
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE PRL-3 induces microvascular and lymphatic vessel formation by facilitating VEGF and VEGF-C expression in lung cancer tissues, thus promoting distant and lymph node metastasis of lung cancer. 19152186 2009
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.100 AlteredExpression disease BEFREE PRL-3 induces microvascular and lymphatic vessel formation by facilitating VEGF and VEGF-C expression in lung cancer tissues, thus promoting distant and lymph node metastasis of lung cancer. 19152186 2009
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.100 Biomarker disease BEFREE PRL-3 plays a key role in the growth of gastric cancer. 19187591 2008
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE PRL-3 plays a key role in the growth of gastric cancer. 19187591 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE PRL-3 may predict poor survival and act as a promising biomarker for individualized therapy for patients with colonic cancer, especially for those diagnosed at an early stage. 19236507 2009
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.100 AlteredExpression disease BEFREE PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. 19322925 2009
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 AlteredExpression disease BEFREE PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. 19322925 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE PRL-3 is a key gene associated with progression and metastasis of colorectal cancer. 19440036 2009