Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 Biomarker disease BEFREE 42% (15 of 21 specimens), but there was only 40% positivity (8 of 20 specimens) for hepatitis B virus envelope antigen whereas 6 of 17 patients (35.29%) showed the presence of antibodies against hepatitis B virus envelope protein. 10738214 2000
CUI: C0276199
Disease: Canarypox (disorder)
Canarypox (disorder)
0.010 GeneticVariation disease BEFREE Canarypox (CP) and fowlpox (FP) constructs, containing the complete env gene (IS(+)) from the HIV-1(SF2) strain, induced a higher profile of epitope recognition than their counterparts expressing the env gene deleted of the putative immunosuppressive region (IS(-)). 10683465 2000
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. 12615904 2003
CUI: C0019159
Disease: Hepatitis A
Hepatitis A
0.030 Biomarker disease BEFREE Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. 12615904 2003
CUI: C0021400
Disease: Influenza
Influenza
0.090 Biomarker disease BEFREE Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors. 16397505 2006
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) env genes were cloned from blood samples of HIV-1-infected Thai patients, and 35 infectious CRF01_AE envelope glycoprotein (Env)-recombinant viruses were established. 19136072 2009
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE Human immunodeficiency virus type 1 (HIV-1) envelope protein (Env) is subject to both neutralizing antibody (NAb) and CD8 T-cell (cytotoxic T-lymphocyte [CTL]) immune pressure. 19515763 2009
CUI: C1175175
Disease: Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome
0.020 Biomarker disease BEFREE Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis. 22028656 2011
CUI: C0021400
Disease: Influenza
Influenza
0.090 Biomarker disease BEFREE Influenza virus hemagglutinin (HA) is the viral envelope protein that mediates viral attachment to host cells and elicits membrane fusion. 22072785 2012
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.100 GeneticVariation disease BEFREE Dengue-1 envelope protein domain III produced in Pichia pastoris: potential use for serological diagnosis. 23993978 2013
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection
0.100 GeneticVariation disease BEFREE West Nile virus genome with glycosylated envelope protein and deletion of alpha helices 1, 2, and 4 in the capsid protein is noninfectious and efficiently secretes subviral particles. 24049184 2013
CUI: C0021400
Disease: Influenza
Influenza
0.090 Biomarker disease BEFREE Influenza vaccines must be frequently reformulated to account for antigenic changes in the viral envelope protein, hemagglutinin (HA). 26739054 2016
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 Biomarker disease BEFREE Hepatitis C Virus Subtype 3a Envelope Protein 1 Binding with Human Leukocyte Antigen Class I Types of Pakistani Population: Candidate Epitopes for Synthetic Peptide Vaccine. 26742442 2015
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections
0.070 Biomarker group BEFREE Herpes simplex virus spread between epithelial cells is mediated by virus tegument and envelope protein complexes including gE/gI and pUL51/pUL7. pUL51 interacts with both pUL7 and gE/gI in infected cells. 31493658 2019
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.100 Biomarker disease BEFREE HIV-1 infection of a human T-cell line transduced with this vector led to induction of sCD4-KDEL synthesis and a block in transport of the HIV envelope protein to the cell surface. 8464877 1993
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection
0.100 Biomarker disease BEFREE Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains. 15956579 2005
CUI: C0011311
Disease: Dengue Fever
Dengue Fever
0.100 Biomarker disease BEFREE Envelope protein gene sequences of all four dengue serotypes (DENV-1-DENV-4) obtained from human sera in Singapore (2008-2010) revealed that constant viral introductions and in situ evolution contribute to viral diversity in Singapore and play important roles in shaping the epidemiology of dengue in the island state. 22036707 2012
CUI: C0014057
Disease: Japanese Encephalitis
Japanese Encephalitis
0.070 Biomarker disease BEFREE Envelope protein gene based molecular characterization of Japanese encephalitis virus clinical isolates from West Bengal, India: a comparative approach with respect to SA14-14-2 live attenuated vaccine strain. 23927571 2013
Human immunodeficiency virus (HIV) II infection category B1
0.100 GeneticVariation disease BEFREE A 240-bp DNA fragment encoding a peptide, designated ENV(80), homologous to a conserved part of the gp41 transmembrane glycoprotein of human immunodeficiency virus (HIV) was chemically synthesized and inserted into different plasmid expression vectors. 3491755 1986
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.100 GeneticVariation disease BEFREE A 385 insertion in the hypervariable region 1 of hepatitis C virus E2 envelope protein is found in some patients with mixed cryoglobulinemia type 2. 11675335 2001
Human immunodeficiency virus (HIV) II infection category B1
0.100 Biomarker disease BEFREE A 700-bp fragment of the human immunodeficiency virus type 1 (HIV-1) env gene, including the V3-V5 region, was successfully amplified by PCR from 10 samples (52.6%) and was subsequently subjected to both a heteroduplex mobility assay for genetic screening and subtyping and DNA sequence analysis (approximately 300 bp) for nucleotide comparison and phylogenetic studies. 7494310 1995
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.100 GeneticVariation group BEFREE A chimeric simian-human immunodeficiency virus (SHIV-4) containing the tat, rev, vpu, and env genes of HIV type 1 (HIV-1) in a genetic background of SIVmac239 was used to develop an animal model in which a primate lentivirus expressing the HIV-1 envelope glycoprotein caused acquired immune deficiency syndrome (AIDS) in macaques. 10087226 1999
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection
0.100 Biomarker disease BEFREE A common conserved peptide harboring predicted T and B cell epitopes in domain III of envelope protein of Japanese Encephalitis Virus and West Nile Virus for potential use in epitope based vaccines. 31300121 2019
CUI: C0014061
Disease: Tick-Borne Encephalitis
Tick-Borne Encephalitis
0.060 Biomarker disease BEFREE A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties. 28625666 2017
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection
0.100 Biomarker disease BEFREE A DNA plasmid was constructed encoding an SCT incorporating the human MHC class I molecule HLA-A2 and the immunodominant peptide SVG9 derived from the envelope protein of West Nile virus (WNV). 20212098 2010