Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Effects of DNA polymerase kappa and mismatch repair on dose-responses of chromosome aberrations induced by three oxidative genotoxins in human cells.
|
31294882 |
2020 |
Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study.
|
31595696 |
2019 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
|
26765445 |
2016 |
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that DNA polymerase κ (POLK), a Y-family DNA polymerase with maximum activity in non-dividing cells, substantially contributes to cccDNA formation during de novo HBV infection.
|
27783675 |
2016 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
|
26765445 |
2016 |
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
|
17099721 |
2007 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
|
17099721 |
2007 |
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions.
|
12036445 |
2002 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The results indicate that Polκ does not suppress BP-induced mutagenesis and carcinogenesis in the colon, but counteracts inflammation-induced mutagenesis in multiple organs..
|
30620413 |
2019 |
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
|
15665310 |
2005 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
|
15202001 |
2004 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
|
15202001 |
2004 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
|
11454676 |
2001 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
DNA polymerase kappa, implicated in spontaneous and DNA damage-induced mutagenesis, is overexpressed in lung cancer.
|
11454676 |
2001 |