|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our investigation of AD brain did not show specific accumulation of p25.
|
11403952 |
2001 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The finding that the interaction of TPPP/p25 with Aβ can produce pathological-like aggregates is tightly coupled with unusual pathology of the Alzheimer disease revealed previously; that is, partial co-localization of Aβ and TPPP/p25 in the case of diffuse Lewy body disease with Alzheimer disease.
|
21832049 |
2011 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, p25 formation may initially be a compensatory response for early learning deficits in Alzheimer's disease, but continued formation could contribute to detrimental changes in Alzheimer's disease.
|
16237316 |
2005 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
An inducible mouse model of p25 accumulation (the CK-p25 mouse) that displays key pathological hallmarks of Alzheimer disease (AD) is used as a gold-standard to test the proposed algorithm by providing a conditional control of rapid neurodegeneration.
|
29723637 |
2018 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown to contribute to the pathogenesis in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD).
|
22262900 |
2012 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined whether p25 was linked to altered neurotransmitter release in AD.
|
20033852 |
2010 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deregulation of Cyclin-dependent kinase 5 (Cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of Alzheimer's disease (AD).
|
29036814 |
2017 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these results reveal a physiological role of p25 production in synaptic plasticity and memory and provide new insights into the function of p25 in Aβ-associated neurotoxicity and AD-like pathology.
|
24725413 |
2014 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cdk5 phosphorylates tau at AD-specific phospho-epitopes when it associates with p25. p25 is a truncated activator, which is produced from the physiological Cdk5 activator p35 upon exposure to Abeta peptides.
|
15592431 |
2005 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
To investigate the association of human immunodeficiency virus (HIV) with various DNA viruses, including hepatitis B virus (HBV), cytomegalovirus (CMV) and Epstein-Barr virus, (EBV), simultaneous detection of HIV p24 antigen, HBV surface antigen and DNA, CMV-DNA and EBV-DNA expression was performed in phytohemagglutinin-stimulated peripheral blood mononuclear (PBMC) culture supernatants obtained from 54 individuals at risk for HIV infection.
|
7588843 |
1995 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The overall sensitivity of the test for diagnosing HIV infection based on detection of p24 antigen and/or antibodies was 92% (95% CI 86% to 98%) (82/89).
|
28062734 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Using RNA fluorescence in situ hybridization, CD32 coexpression with HIV RNA or p24 was detected after in vitro HIV infection (peripheral blood mononuclear cell and tissue) and in vivo within lymph node tissue from HIV-infected individuals.
|
29669853 |
2018 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Measurement of p24 antigen in serum was, in contrast, a less sensitive marker of HIV infection: only 5/13 infants had positive p24 antigen results.
|
9240857 |
1997 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In a second experiment, HIV infection was studied: (1) sequentially by RT assay and P24 immunocapture on several clones; (2) by cocultivation of infected clones with umbilical cord lymphocytes.
|
2121340 |
1990 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Given that initial HIV infection of an individual instigates abundant HIV replication from inception until death, and that the life of infected T-cells is only several days, the administration of AZT should lead both in vitro and in vivo (i) to decreased formation of proviral DNA; and thus (ii) to decreased frequencies of 'HIV isolation' (detection of p24 or reverse transcription or both) in stimulated cultures/cocultures of T-cells from seropositive individuals; (iii) to decreased synthesis of HIV p24 and RNA ('antigenaemia', 'plasma viraemia', 'viral load') ultimately resulting in low or absent levels of all three parameters; and (iv) to a perfect and direct correlation between all these parameters.
|
11594171 |
1999 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Monocytes treated with interferon-alpha (IFN-alpha) at virus challenge show no evidence of human immunodeficiency virus (HIV) infection: no p24 antigen or reverse transcriptase (RT) activity, no viral mRNA and no proviral DNA.
|
1883515 |
1991 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Of these "nonprogressors", 23 (96%) had evidence of HIV infection by either HIV culture or the polymerase chain reaction (PCR) for HIV DNA, although only 1 (4%) had a positive assay for HIV RNA (by PCR) and no one was positive for p24 antigen.
|
1673465 |
1991 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
More and more countries test for HIV infection using combination assays that simultaneously detect p24 antigen and HIV antibodies.
|
29020658 |
2017 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Testing for the p24 antigen of the human immunodeficiency virus (HIV) may detect early HIV infection in the seronegative window; however, falsely reactive results may occur in cadaver specimens.
|
11322416 |
2001 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
An immunological explanation for the protective role for HLA B27 in HIV disease is that B27+ patients have a specific and strong CTL response against the p24 epitope, a conservative HIV protein that does not easily mutate.
|
15332431 |
2004 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
This approach may be used to confirm true status of the HIV infection when p24 results are negative or HIV RNAs in serum/plasma are below the threshold of detection.
|
9179766 |
1997 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Placentas and fetal organs were examined by routine light microscopy, immunostaining for p24 capsid protein, and in situ PCR to localize which cells were infected with HIV-1 subtype E. The number of previous abortions was not a factor in placental HIV infection since this number was higher in seronegative women (P < 0.01).
|
15846390 |
2005 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Because IFN-gamma enhances IgG2 production, and IgG2 antibodies to HIV antigens and the 'high-affinity' polymorphism of FcgammaRIIa (the major Fc receptor for IgG2) have been associated with a favourable outcome of HIV infection, we examined the association of IgG2 antibodies to HIV p24 and 'high-affinity' polymorphisms of FcgammaRIIa with control of HIV replication in these patients.
|
20634666 |
2010 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Immune complex formation causes underdetection of p24 antigen in human immunodeficiency virus (HIV) infection.
|
8035017 |
1994 |
|
HIV Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Assay of human vitreous specimens obtained postmortem for HIV antibodies, or HIV p24 antigen, is reported to be a reliable technique to demonstrate HIV infection in possible cornea donors from whom serum could not be obtained.
|
8407115 |
1993 |