|
Split ends
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also report that SPEN regulates migration in breast cells, but only in those harboring primary cilia, and that KIF3A silencing, a critical factor in primary cilia, partially reverses SPEN's effects, suggesting that SPEN may coordinate cellular movement through primary cilia-dependent mechanisms.
|
28877752 |
2017 |
|
Cleft secondary palate
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a.
|
27259005 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A correlation between KIF3A loss and a poorer NSCLC prognosis as well as β-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/β-catenin signalling and tumourigenesis in NSCLC.
|
27596264 |
2016 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
|
26760767 |
2016 |
|
Cystic kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease.
|
27181777 |
2016 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
|
27596264 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
|
26760767 |
2016 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we generated renal epithelium-specific Kif3a/Trp53 and Vhl/Kif3a/Trp53 mutant mice to investigate whether primary cilium deletion would accelerate the development of cystic precursor lesions or cause their progression to ccRCC.
|
27126173 |
2016 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
|
26760767 |
2016 |
|
Congenital cystic kidney disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease.
|
27181777 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
|
26760767 |
2016 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
|
27596264 |
2016 |
|
Nephronophthisis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hence, cell senescence is a central feature in nephronophthisis type 7 and Kif3a is unexpectedly required for efficient DNA damage response and cell cycle arrest.
|
27181777 |
2016 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
|
27596264 |
2016 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that KIF3A is essential for GBM cell ciliogenesis, but its role in modulating GBM cell behavior is highly variable.
|
26760767 |
2016 |
|
Cystic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The Kif3a knockout mouse is an established non-orthologous mouse model of cystic kidney disease.
|
27181777 |
2016 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inactivation of KIF3a may improve survival of patients with advanced prostate cancer in which Wnt signaling is activated.
|
24413182 |
2014 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inactivation of KIF3a may improve survival of patients with advanced prostate cancer in which Wnt signaling is activated.
|
24413182 |
2014 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we use tamoxifen-induced ablation of Kif3a in GNPs of postnatal Ptch(+/-) mouse cerebella to show that KIF3a is necessary for MB formation.
|
23389290 |
2013 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we use tamoxifen-induced ablation of Kif3a in GNPs of postnatal Ptch(+/-) mouse cerebella to show that KIF3a is necessary for MB formation.
|
23389290 |
2013 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we use tamoxifen-induced ablation of Kif3a in GNPs of postnatal Ptch(+/-) mouse cerebella to show that KIF3a is necessary for MB formation.
|
23389290 |
2013 |
|
aspirin intolerance
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on AIA, providing a new step toward controlling aspirin intolerance in asthmatics.
|
20922562 |
2011 |
|
Immune System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The kinesin family number 3A (KIF3A) gene on the human chromosomal 5q31-33 region, which is known as a susceptibility locus for immune diseases including asthma, plays a crucial role in generation of cilia.
|
20922562 |
2011 |
|
Nasal Polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A treatment with aspirin in the human bronchial epithelial cells increased the mRNA expression level of KIF3A compared to that of the untreated control (P ≤ 0.01), and nasal polyp epithelia from aspirin-intolerant asthma (AIA) patients also showed a higher expression of KIF3A protein than aspirin-tolerant asthma controls.
|
20922562 |
2011 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results show that the variants carried by the haplotypes of SLC22A4, SLC22A5 and KIF3A region potentially contribute to tuberculosis susceptibility among the Thai population.
|
20485362 |
2010 |