|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, Northern blot analysis indicated abundant expression of both p55 and p75 mRNA in RA synovial joint MNC.
|
1320571 |
1992 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast to RA synovial MNC, p75 or p55 TNF-R expression was not significantly increased in osteoarthritis synovial MNC.
|
1320571 |
1992 |
|
HIV-1 infection
|
0.060 |
Biomarker
|
disease |
BEFREE |
Expression of a functional p75 interleukin-2 receptor on lung lymphocytes from patients with human immunodeficiency virus type 1 (HIV-1) infection.
|
1430108 |
1992 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.060 |
Biomarker
|
disease |
BEFREE |
Expression of a functional p75 interleukin-2 receptor on lung lymphocytes from patients with human immunodeficiency virus type 1 (HIV-1) infection.
|
1430108 |
1992 |
|
Hodgkin Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
A similar pattern (Tac positivity and p75 negativity) was noted in H-RS cells in lymph nodes involved by Hodgkin's disease.
|
1691591 |
1990 |
|
Leukemia, Large Granular Lymphocytic
|
0.020 |
Biomarker
|
disease |
BEFREE |
To investigate the role of p55 and p75 chains of interleukin-2 receptor (IL-2R) on the activation of granular lymphocytes (GL) in patients with lymphoproliferative disease of granular lymphocytes (LDGL), the cells obtained from 11 LDGL patients (belonging to the CD3+ group) were studied for (a) the surface expression and (b) mRNA transcripts of the p55 and p75 IL-2R after activation with anti-CD3 monoclonal antibody (mAb) or interleukin-2 (IL-2).
|
1835747 |
1991 |
|
Alveolitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To investigate the mechanisms accounting for the T cell alveolitis taking place in the lung of HP patients and their pattern of growth, cells recovered from the bronchoalveolar lavage (BAL) of seven patients were evaluated for: 1) the expression of activation markers, including IL-2R (p55 and p75 subunits), HLA-DR and VLA-1 Ag; 2) the ability of IL-2 and IL-4 to induce in vitro proliferation; 3) the capability to synthesize and release IL-2 by determining the levels of IL-2 in BAL cell-free supernatants and by evaluating the presence of mRNA transcripts for IL-2; and 4) the molecular configuration of the beta- and gamma-genes of the TCR.
|
2144545 |
1990 |
|
Leukemia, Large Granular Lymphocytic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Cell membrane expression and functional role of the p75 subunit of interleukin-2 receptor in lymphoproliferative disease of granular lymphocytes.
|
2146981 |
1990 |
|
Carcinoma of larynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TNFR55-selective mutants (R32W, E146K and R32W-S86T) which bind poorly to TNFR75 displayed similar potency to wild-type TNF in causing cytotoxicity of a human laryngeal carcinoma-derived cell line (HEp-2) and cytostasis in a human leukaemic cell line (U937).
|
7509279 |
1994 |
|
Fibrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We compared the biological function of the human tumor necrosis factor receptors p55 (hTNF-R55) and p75 (hTNF-R75) expressed in the murine (m) fibrosarcoma cell line L929.
|
7578985 |
1995 |
|
Adult Fibrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We compared the biological function of the human tumor necrosis factor receptors p55 (hTNF-R55) and p75 (hTNF-R75) expressed in the murine (m) fibrosarcoma cell line L929.
|
7578985 |
1995 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
While a fragment covering amino acids (aa) 495 to 691 of pp150 (150/1) was the most suitable antigen for the identification of infected individuals in general, immunoglobulin M antibodies against the C-terminal parts of pp150 (aa 862 to 1048; 150/7) and p52 (aa 297 to 433; 52/3) proved to be excellent serological markers to monitor acute HCMV infection.
|
8027354 |
1994 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.
|
8305739 |
1993 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also studied the colon carcinoma cell line HT-29 and its metastatic counterpart HTM-29 and we observed specific expression of the p52 NF-kappa B-related protein in the metastatic cells.
|
8311838 |
1994 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Unlike hairy cells, only 8 of the 15 B-cell chronic lymphocytic leukemia cases tested showed a weak expression of the p75 antigen on a small proportion of cells.
|
8329708 |
1993 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Unlike hairy cells, only 8 of the 15 B-cell chronic lymphocytic leukemia cases tested showed a weak expression of the p75 antigen on a small proportion of cells.
|
8329708 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we have investigated the leukemic cells obtained from 16 patients with acute myeloid leukemia (AML) at diagnosis for the membrane expression of p55 (alpha) and p75 (beta) interleukin-2 receptor (IL-2R) chains using specific monoclonal antibodies (mAbs), as well as for the presence of their transcripts using Northern blot analysis.
|
8445947 |
1993 |
|
Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents.
|
8656283 |
1996 |
|
Central neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents.
|
8656283 |
1996 |
|
Childhood Neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In a series of studies using, in turn, neuroblastoma cell lines that express only p75, mutant NGF species that bind selectively to either p75 or trkA, and a polyclonal antibody that binds to the NGF-binding domain of p75, we demonstrate that NGF binding to p75 is both necessary and sufficient for the abrogation of apoptosis in neuroblastoma cells treated with antimitotic agents.
|
8656283 |
1996 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The low affinity p75 neurotrophin receptor (p75NTR) is a cysteine-rich transmembrane glycoprotein which is frequently overexpressed in advanced stages of human melanoma.
|
8908597 |
1996 |
|
Neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Induction of apoptosis by p75 neurotrophin receptor in human neuroblastoma cells.
|
9136990 |
1997 |
|
Central neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Induction of apoptosis by p75 neurotrophin receptor in human neuroblastoma cells.
|
9136990 |
1997 |
|
Childhood Neuroblastoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Induction of apoptosis by p75 neurotrophin receptor in human neuroblastoma cells.
|
9136990 |
1997 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NGF, BDNF, NT-3, NT-4/5, as well as trkB, trkC and p75 mRNA levels were unchanged in AD parietal cortex and cerebellum as compared to controls.
|
9507943 |
1998 |