|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17A and IL-17F play an important role in regulating skin inflammation through neutrophils.
|
31629113 |
2020 |
|
hiv-infection/aids
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data indicated that the NF-κB and MAPK pathways are involved in the repair of barrier integrity mediated by IL-17A and IL-17F, and IL-17 pathways are potential targets for gut barrier restoration therapies during HIV/AIDS.
|
30951887 |
2020 |
|
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17A and IL-17F play an important role in regulating skin inflammation through neutrophils.
|
31629113 |
2020 |
|
Bronchopulmonary Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
By conducting the MCCV on seed cross-talk, 3 hub cross-talk for BPD were uncovered: i) The pair of pathways role of interleukin-17F (IL-17F) in allergic inflammatory airway diseases and role of IL-17A in psoriasis; ii) the pair of pathways role of IL random forest 17A in psoriasis and IL-17A signaling in fibroblasts and ii) the pair of pathways IL-17A signaling in airway cells and role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza.
|
30930971 |
2019 |
|
Collagen Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |
|
Digestive System Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The IL-17A rs2275913 and IL-17F rs763780 polymorphisms were associated with susceptibility to digestive system neoplasms.
|
30562686 |
2019 |
|
Glomerulitis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the association of rs2275913 IL17A and rs2397084, rs11465553 and rs763780 IL17F gene polymorphisms with histopathological changes in transplanted kidney biopsies such as: glomerulitis, tubulitis, arteritis, cell infilitration and fibrosis.
|
30961540 |
2019 |
|
Ichthyoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although striking upregulation of TH17 pathway genes (IL17F and IL36B/G) resembling that seen in patients with psoriasis was common to all patients with ichthyoses in a severity-related manner, patients with Netherton syndrome showed the greatest T-cell activation (inducible costimulator [ICOS]) and a broader immune phenotype with T<sub>H</sub>1/IFN-γ, OASL, and T<sub>H</sub>2/IL-4 receptor/IL-5 skewing, although less than seen in patients with AD (all P < .05).
|
29803800 |
2019 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Studies on rhIL-17A/rhIL-17F are promising approach to contribute to the understanding of human IL-17A and IL-17F-related intestinal diseases.
|
31377676 |
2019 |
|
Osteoarthritis of hip
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The haplotype G-T (IL17A-IL17F; rs2275913-rs763780) is associated with protection to the disease in hip OA (p < 0.01).
|
31042000 |
2019 |
|
Rheumatism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |
|
Dermatologic disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Baseline serum levels of IL-17A and IL-17F were positively correlated with baseline skin disease scores (r = 0.39-0.62).
|
31070869 |
2019 |
|
Ankylosing spondylitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The frequencies of IL‑17A, IL‑17B and IL‑17C mRNA upregulation in lung squamous cell carcinoma were lower than those in lung adenocarcinoma (2.7, 1.9 and 2.1%, respectively), whereas the frequencies of IL‑17D, IL‑25 and IL‑17F mRNA upregulation were higher in lung squamous cell carcinoma than those in lung adenocarcinoma (3, 6 and 6%, respectively).
|
31059089 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The frequencies of IL‑17A, IL‑17B and IL‑17C mRNA upregulation in lung squamous cell carcinoma were lower than those in lung adenocarcinoma (2.7, 1.9 and 2.1%, respectively), whereas the frequencies of IL‑17D, IL‑25 and IL‑17F mRNA upregulation were higher in lung squamous cell carcinoma than those in lung adenocarcinoma (3, 6 and 6%, respectively).
|
31059089 |
2019 |
|
Malignant neoplasm of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-17F Has Anti-Tumor Effects in Oral Tongue Cancer.
|
31083515 |
2019 |
|
Ichthyosis linearis circumflexa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although striking upregulation of TH17 pathway genes (IL17F and IL36B/G) resembling that seen in patients with psoriasis was common to all patients with ichthyoses in a severity-related manner, patients with Netherton syndrome showed the greatest T-cell activation (inducible costimulator [ICOS]) and a broader immune phenotype with T<sub>H</sub>1/IFN-γ, OASL, and T<sub>H</sub>2/IL-4 receptor/IL-5 skewing, although less than seen in patients with AD (all P < .05).
|
29803800 |
2019 |
|
Endometriosis of uterus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum levels of interleukin (IL) 23 (237.77 pg/mL ± 70.97 in the ADE-group versus 1855.04 ± 1411.33 in the control group, P = .019), IL25 (31.98 ± 8.54 vs 222.08 ± 170.90, respectively, P = .006), IL31 (10.13 ± 3.83 vs 91.51 ± 71.21, respectively, P = .034), IL33 (3.77 ± 1.23 vs 17.86 ± 11.49, respectively, P = .016), and IL17F (16.29 ± 2.35 vs 30.12 ± 8.29, respectively, P = .042) were significantly lower in the women with adenomyosis when compared to the controls In the FOC/DIF-ADE group, the serum levels of IL23, IL31, IL25, and IL33 were significantly lower when compared to the control group.
|
30518300 |
2019 |
|
Tongue Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-17F Has Anti-Tumor Effects in Oral Tongue Cancer.
|
31083515 |
2019 |
|
Severe depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
HARS scores correlated with IL-17A in the SA group and with IL-17A, IL-17F, and IL-2 in the SD + SA group (p < 0.02).
|
30943938 |
2019 |
|
airway disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
By conducting the MCCV on seed cross-talk, 3 hub cross-talk for BPD were uncovered: i) The pair of pathways role of interleukin-17F (IL-17F) in allergic inflammatory airway diseases and role of IL-17A in psoriasis; ii) the pair of pathways role of IL random forest 17A in psoriasis and IL-17A signaling in fibroblasts and ii) the pair of pathways IL-17A signaling in airway cells and role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza.
|
30930971 |
2019 |
|
Acute anterior uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |
|
Cytokine storm
|
0.010 |
Biomarker
|
disease |
BEFREE |
By conducting the MCCV on seed cross-talk, 3 hub cross-talk for BPD were uncovered: i) The pair of pathways role of interleukin-17F (IL-17F) in allergic inflammatory airway diseases and role of IL-17A in psoriasis; ii) the pair of pathways role of IL random forest 17A in psoriasis and IL-17A signaling in fibroblasts and ii) the pair of pathways IL-17A signaling in airway cells and role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza.
|
30930971 |
2019 |
|
Influenza A (H3N2)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Influenza A (H3N2) correlated with higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 1β (IL-1β), IL-17A, IL-17E, IL-17F, IL-21, IL-22, and IL-23 (P < 0.05 by analysis of variance [ANOVA]) compared with respiratory syncytial virus (RSV).
|
30715745 |
2019 |
|
Axial spondyloarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |