CHRM2, cholinergic receptor muscarinic 2, 1129

N. diseases: 91; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 GeneticVariation disease BEFREE Three genes (CHRM2, FAM5C and MYLK) were further confirmed to show methylation rates increased with progression from NC to GPL, then to GC. 22377736 2012
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.010 Biomarker disease BEFREE An antibody for the muscarinic M2 receptor is related to atrial fibrillation, an antibody targeting Na-K-ATPase is closely related to sudden cardiac death from fatal ventricular arrhythmias, and an autoantibody for troponin I increases the L-type calcium current and is related to myocardial damage. 21617318 2011
CUI: C0237123
Disease: Alcohol or Other Drugs use
Alcohol or Other Drugs use 		0.010 GeneticVariation disease BEFREE These results suggest that CHRM2 variants are potentially relevant for adolescent substance use and that temperamental risk factors could contribute to these associations. 21494862 2011
CUI: C0028043
Disease: Nicotine Dependence
Nicotine Dependence 		0.010 Biomarker disease BEFREE The impact of three SNPs in CHRM2 on smoking behavior/nicotine addiction was investigated using logistic regression models or a quasi-Poisson regression model, respectively. 19644963 2010
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.010 GeneticVariation phenotype BEFREE Our data provide further evidence that variations in CHRM2 may be associated with the genetic risk of addiction in general or with certain personality traits that predispose to the development of addiction. 19644963 2010
CUI: C0154409
Disease: Recurrent major depressive episodes
Recurrent major depressive episodes 		0.010 Biomarker disease BEFREE Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. 19181679 2009
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 GeneticVariation disease BEFREE DNA sequence variation at the CHRM2 locus is a determinant of cardiac autonomic function in the postexercise early recovery phase and predicts cardiac mortality after AMI. 18979273 2009
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.010 Biomarker group BEFREE Circulating autoantibodies against the M2-muscarinic acetylcholine receptor (CHRM2) have been detected in patients with dilated cardiomyopathy (DCM). 18451336 2008
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.010 GeneticVariation group LHGDN A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. 18451336 2008
CUI: C1449563
Disease: Cardiomyopathy, Familial Idiopathic
Cardiomyopathy, Familial Idiopathic 		0.010 GeneticVariation disease BEFREE Linkage analysis demonstrated cosegregation of the microsatellite markers, D7S509 and D7S495 that flank the CHRM2 gene, with the familial form of DCM. 18451336 2008
CUI: C0003130
Disease: Anoxia
Anoxia 		0.010 Biomarker phenotype LHGDN Transient hypoxia induces sequestration of M1 and M2 muscarinic acetylcholine receptors. 16336219 2006
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 GeneticVariation group BEFREE These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders. 15229186 2004
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 GeneticVariation phenotype BEFREE These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders. 15229186 2004
CUI: C0028754
Disease: Obesity
Obesity 		0.020 GeneticVariation disease BEFREE p.R270H (rs116454156) in the long chain fatty acid 7TM receptor FFAR4 (GPR120) which results in impaired Gαq (Gq) coupled signalling, has been associated with obesity. 27068006 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.020 GeneticVariation disease BEFREE Two of the seven SNPs located in CHRM2, the 3' untranslated region rs8191992 and rs6962027, differed significantly in allele frequencies between patients with asthma and healthy controls [odds ratio (OR) 1.42, 95 % confidence interval (95 % CI) 1.14-1.77, P = 0.001, and OR 1.50, 95 % CI 1.21-1.87, P = 0.0002, respectively]. 24430298 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.020 Biomarker disease BEFREE CHRM2 genotypic variance predicted longitudinal BMI and obesity status. 25155933 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.020 GeneticVariation disease BEFREE This group also showed a greater prevalence of a CHRM2 genotype previously associated with substance dependence and Major Depressive Disorder as well as a modest elevation on a non-planning impulsiveness scale. 24530440 2014
CUI: C0340427
Disease: Familial dilated cardiomyopathy
Familial dilated cardiomyopathy 		0.020 GeneticVariation disease BEFREE Previously, we reported a missense mutation (C722G) in the M2-muscarinic acetylcholine receptor (CHRM2) gene associated with familial dilated cardiomyopathy. 23743182 2013
CUI: C0340427
Disease: Familial dilated cardiomyopathy
Familial dilated cardiomyopathy 		0.020 GeneticVariation disease BEFREE A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy. 18451336 2008
CUI: C0086133
Disease: Depressive Syndrome
Depressive Syndrome 		0.020 GeneticVariation disease BEFREE Genet., 13, 1903-1911] reported that variation in CHRM2 gene predisposed to alcohol dependence (AD) and major depressive syndrome. 16000316 2005
CUI: C0086133
Disease: Depressive Syndrome
Depressive Syndrome 		0.020 GeneticVariation disease BEFREE Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. 15229186 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.020 AlteredExpression disease BEFREE One immunological component of asthma is believed to be the interaction of eosinophils with parasympathetic cholinergic nerves and a consequent inhibition of acetylcholine muscarinic M2 receptor activity, leading to enhanced acetylcholine release and bronchoconstriction. 12948933 2003
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.020 Biomarker disease BEFREE Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women. 12116189 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 GeneticVariation disease BEFREE Neuropsychiatric behaviours in Alzheimer's disease (AD) patients have been associated with neocortical alterations of presynaptic cholinergic and muscarinic M2 receptor markers. 18373228 2008
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.030 AlteredExpression disease BEFREE Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins. 16181410 2005