|
Substance Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
Substance addiction, which includes alcohol, has been shown to involve the major nicotinic acetylcholine receptor subunit CHRNA5.
|
20438829 |
2010 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nicotine dependence is linked to single nucleotide polymorphisms in the CHRNB4-CHRNA3-CHRNA5 gene cluster encoding the α3β4α5 nicotinic acetylcholine receptor (nAChR).
|
21555077 |
2011 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Primary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHRNA5, encoding the nicotinic α5 subunit, is implicated in multiple disorders, including nicotine addiction and lung cancer.
|
20700147 |
2011 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5 gene expression variation may play a role in individual susceptibility to lung cancer.
|
23430818 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5 gene expression variation may play a role in individual susceptibility to lung cancer.
|
23430818 |
2013 |
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5 gene expression variation may play a role in individual susceptibility to lung cancer.
|
23430818 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5-A3-B4, the gene cluster encoding nicotinic acetylcholine receptor subunits, is associated with lung cancer risk and smoking behaviors in people of European descent.
|
23844051 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5-A3-B4, the gene cluster encoding nicotinic acetylcholine receptor subunits, is associated with lung cancer risk and smoking behaviors in people of European descent.
|
23844051 |
2013 |
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CHRNA5-A3-B4, the gene cluster encoding nicotinic acetylcholine receptor subunits, is associated with lung cancer risk and smoking behaviors in people of European descent.
|
23844051 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer.
|
29416783 |
2018 |
|
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer.
|
29416783 |
2018 |
|
Primary malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer.
|
29416783 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer.
|
30543688 |
2018 |
|
Nicotine Dependence
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |
|
Schizophrenia
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |
|
Schizophrenia
|
0.480 |
Biomarker
|
disease |
PSYGENET |
A CHRNA5 allele related to nicotine addiction and schizophrenia.
|
21418140 |
2011 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
A case-control study of 866 ESCC patients and 952 healthy controls was performed to study the association of polymorphisms (rs667282 and rs3743073) in CHRNA5-A3-B4 with cancer risk using logistic regression models.
|
23844051 |
2013 |
|
Primary malignant neoplasm
|
0.070 |
GeneticVariation
|
group |
BEFREE |
A case-control study of 866 ESCC patients and 952 healthy controls was performed to study the association of polymorphisms (rs667282 and rs3743073) in CHRNA5-A3-B4 with cancer risk using logistic regression models.
|
23844051 |
2013 |
|
Nicotine Dependence
|
0.400 |
Biomarker
|
disease |
BEFREE |
A cluster of three nicotinic acetylcholine receptor genes on chromosome 15 (CHRNA5/CHRNA3/CHRNB4) has been shown to be associated with nicotine dependence and smoking quantity.
|
19628476 |
2009 |
|
Paranoia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.
|
23308091 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A four-SNP haplotype spanning CHRNA5 (rs11637635 C, rs17408276 T, rs16969968 G) and CHRNA3 (rs578776 G) was associated with increased lung cancer risk (P = 0.002).
|
20587604 |
2010 |