|
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.
|
31288250 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Recent human genetic association studies have implicated the gene cluster CHRNA3-CHRNA5-CHRNB4 encoding the α3, α5, and β4 subunits of the nAChR in susceptibility to develop nicotine and alcohol dependence; however, their role in ethanol-mediated behaviors is unknown due to the lack of suitable and selective research tools.
|
21048701 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
We also observed two SNPs associated with alcohol dependence, that is, rs615470 in CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).
|
20485328 |
2010 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
CTD_human |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease.
|
22438940 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
Biomarker
|
disease |
PSYGENET |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Functional studies in human brain reveal that the variants associated with alcohol dependence are also associated with altered steady-state levels of CHRNA5 mRNA.
|
18414406 |
2009 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860).
|
23591849 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present hospital-based, case-control study, we determined whether polymorphism in rs503464 of CHRNA5 is associated with lung cancer risk in Chinese individuals.
|
23314339 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The functional A variant of rs1696698 in CHRNA5 had the strongest association with lung cancer (OR = 1.98, 95% CI = 1.25 to 3.11, P = .003).
|
20554942 |
2010 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The potential association of three polymorphisms in the CHRNA3 (rs1051730(G > A)), CHRNA5 (rs16969968(G > A)), and AGPHD1 (rs8034191(A > G)) with the lung cancer risk has been widely investigated, but the results are inconsistent.
|
27072204 |
2016 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, no study has evaluated the association between CHRNA5-A3-B4 gene cluster variants (rs667282 and rs3743073, two variants modifying lung cancer risk) and risk of gastric cancer.
|
23576140 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism of CHRNA5 did not have a significant influence on the elevated risk of lung cancer and COPD.
|
21955800 |
2012 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variation in the CHRNA5-A3-B4 gene cluster is a promising candidate region for smoking behavior and has been linked to multiple smoking-related phenotypes (e.g., nicotine dependence) and diseases (e.g., lung cancer).
|
22071378 |
2011 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors applied a rigorous statistical approach, mediation analysis, to examine the mediating effect of smoking behavior and self-reported, physician-diagnosed emphysema (chronic obstructive pulmonary disease [COPD]) on the relation between the CHRNA5-A3 region genetic variant rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, no studies have investigated the association between CHRNA5 rs3841324, which has been proven to have the highest association with CHRNA5 mRNA expression, and the risk of other smoking-associated cancers, except lung cancer.
|
25329654 |
2014 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The transcription profile of CHRNA5 depleted MCF7 cells showed a significant positive correlation with that of A549 lung cancer cell line while exhibiting a negative association with the CHRNA5 co-expression profile obtained from Cancer Cell Line Encylopedia (CCLE).
|
30543688 |
2018 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer.
|
26689306 |
2016 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
From smoking to lung cancer: the CHRNA5/A3/B4 connection.
|
20581870 |
2010 |