|
Alcohol Use Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
More recent studies in family-based samples have implicated GABRA2, nicotinic receptor genes such as CHRNB3, and a number of other specific single genes as associated with alcohol use disorders.
|
25399692 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Replication in an independent sample supports the role of rare variants in CHRNB3 and alcohol dependence (P = 0.006).
|
24057674 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In a real data application, we apply our method to the sequencing data from Minnesota Twin Study (MTS) and found potential associations of several nicotine receptor subunit (CHRN) genes, including CHRNB3, associated with nicotine dependence and/or alcohol dependence.
|
28850771 |
2017 |
|
Antisocial behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.
|
27085880 |
2016 |
|
Attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, a significant CHRNB3 variant×ADHD symptom interaction was observed, such that individuals with elevated ADHD symptoms and a particular CHRNB3 variant were at increased risk of cigarette use over time.
|
23899432 |
2013 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the CHRNB3-A6 locus contains multiple variants affecting risk for vulnerability to cocaine and nicotine dependence as well as bipolar disorder, suggesting that they have pleiotropic effects.
|
24675634 |
2014 |
|
Bipolar Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In the investigation of pleiotropic effects of these SNPs on bipolar disorder, two highly correlated synonymous SNPs in CHRNB3, rs4952 and rs4953, were significantly associated with bipolar disorder (odds ratio 1.7, 95% confidence interval: 1.2-2.4, P=0.001).
|
21191315 |
2011 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Our results suggest that (i) bipolar disorder does not modify the association between nicotine dependence and nicotinic receptor subunit genes, and (ii) variants in CHRNB3/CHRNA6 are independently associated with bipolar disorder.
|
21191315 |
2011 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Cannabis Abuse
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rs16969968 in CHRNA5 (and its proxy, rs1051730 in CHRNA3) and rs1451240, a proxy for rs13280604 in CHRNB3, were associated with CPD after Bonferroni correction (p<0.006). rs1451240 was also associated with DSM-IV cannabis abuse/dependence.
|
25770649 |
2015 |
|
Carcinogenesis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although gene polymorphisms on nicotinic acetylcholine receptor subunits CHRNB3-CHRNA6 region gene have been found to correlate with smoking behavior and lung cancer susceptibility in Chinese Han population, the combined effect between the smoking-related genetic variants and smoking behavior on psoriasis vulgaris (PV) has been unreported.
|
24792900 |
2014 |
|
Cocaine Dependence
|
0.320 |
Biomarker
|
disease |
PSYGENET |
For European Americans, we find increased DSM-IV cocaine dependence symptoms (FamSKAT P = 2 × 10(-4)) and increased DSM-IV alcohol dependence symptoms (FamSKAT P = 5 × 10(-4)) among carriers of missense variants in CHRNB3.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.
|
24057674 |
2014 |
|
Cocaine Dependence
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The common variant rs13273442 in the CHRNB3-CHNRA6 region is associated significantly with nicotine dependence in European Americans and African Americans across studies recruited for nicotine, alcohol and cocaine dependence.
|
24401102 |
2014 |
|
cocaine use
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Using genotypic data from a GWAS of the Study of Addiction: Genetics and Environment (SAGE) dataset, we tested for association of CHRNB3-A6 SNPs with DSM-5 cocaine use disorder.
|
24675634 |
2014 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Dizziness
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Multiple SNPs in the putative promoter region of the CHRNB3 gene were nominally associated with "dizziness" experience from the first few cigarettes (P < 0.01).
|
19760673 |
2010 |
|
Idiopathic generalized epilepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The area where the LOD score reaches the maximum encompasses the location of the gene for the beta3-subunit of the nicotinic acetylcholine receptor (CHRNB3), thus making this gene a possible candidate for these specific forms of adolescent-onset IGE.
|
10205274 |
1999 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk.
|
27050379 |
2016 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although gene polymorphisms on nicotinic acetylcholine receptor subunits CHRNB3-CHRNA6 region gene have been found to correlate with smoking behavior and lung cancer susceptibility in Chinese Han population, the combined effect between the smoking-related genetic variants and smoking behavior on psoriasis vulgaris (PV) has been unreported.
|
24792900 |
2014 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To test whether rs1051730 (C/T), a tag for multiple variants in the CHRNA5-CHRNA3-CHRNB3 cluster, is associated with a change in risk of smoking-related mortality and morbidity in the Malmö Diet and Cancer study, a population-based prospective cohort study.
|
26689306 |
2016 |