|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present report, we examine the disposition of PS NTF and CTF assemblies in stable mouse N2a neuroblastoma cell lines expressing human PS polypeptides.
|
10318786 |
1999 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present report, we examine the disposition of PS NTF and CTF assemblies in stable mouse N2a neuroblastoma cell lines expressing human PS polypeptides.
|
10318786 |
1999 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present report, we examine the disposition of PS NTF and CTF assemblies in stable mouse N2a neuroblastoma cell lines expressing human PS polypeptides.
|
10318786 |
1999 |
|
Familial Alzheimer Disease (FAD)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
From the evidence of NTF and CTF homodimerization, we propose the contribution of two NTFs and two CTFs, instead of a single NTF:CTF heterodimer, to the functional presenilin-gamma-secretase complex and that FAD mutations affect the assembly or stability of this complex.
|
11557046 |
2001 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize observations indicating that both CTF and Abeta may participate in the neuronal degeneration in the progress of AD by differential mechanisms.
|
15821343 |
2005 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
This system contains multimerized E2F-responsive elements in combination with the binding sites for ubiquitous transcription factors Sp1 and CTF/NF1. pESM6 could drive a high-level transgene expression comparable to that of the CMV IE promoter and exert constitutive activity in cells expressing DNA tumor viral oncogenes.
|
16461008 |
2006 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BCL6 degradation caused by the HB-EGF-CTF also might induce cyclin D2 expression in human gastric cancers.
|
19337254 |
2009 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DNA repair genes POLI and ESCO1 are proposed as susceptibility genes for TMPRSS2-ERG fusion-positive PCa that warrant further investigation.
|
19861517 |
2009 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The DNA repair genes POLI and ESCO1 are proposed as susceptibility genes for TMPRSS2-ERG fusion-positive PCa that warrant further investigation.
|
19861517 |
2009 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
We recently reported a correlation between proteolytic product of gelsolin (carboxyl-terminal fragment of gelsolin, gelsolin-CTF) and severity of Alzheimer's disease.
|
20847428 |
2010 |
|
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gelsolin-CTF was not observed in frontal cortex of young DS (age 0.5-23 years) and age-matched control subjects.
|
20847428 |
2010 |
|
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Gelsolin-CTF was not observed in frontal cortex of young DS (age 0.5-23 years) and age-matched control subjects.
|
20847428 |
2010 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
The amyloid-β (Aβ) peptide is contained within the C-terminal fragment (β-CTF) of the amyloid precursor protein (APP) and is intimately linked to Alzheimer's disease.
|
21186781 |
2011 |
|
Hyperactive behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
One of these fragments, named 100- to 115-kDa p95HER2 or 611-CTF, is hyperactive because of its ability to form homodimers maintained by intermolecular disulfide bonds.
|
21343397 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
The overexpression of LAGE1, MAGE-A4 and NY-ESO1 was found in 39, 90.2 and 41.4% of ESCC samples respectively.
|
21613820 |
2011 |
|
Alzheimer's Disease
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Processing of β-CTF by γ-secretase releases amyloid-β (Aβ), which is assumed to cause AD.
|
22170863 |
2012 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that sAPPβ and/or β-CTF, rather than Aβ, are the toxic species causing dementia, and indicate that reducing β-cleavage of APP is an appropriate therapeutic approach to treating human dementias.
|
22170863 |
2012 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated.
|
23312906 |
2013 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies.
|
23312906 |
2013 |
|
Mesothelioma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes.
|
23312906 |
2013 |
|
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
The AAV1-I(2NTF-CTF) rats not only offer a disease-relevant model of the sporadic form of Alzheimer's disease but also represent a practical and widely available animal model.
|
23948903 |
2013 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
The AAV1-I(2NTF-CTF) rats show neurodegeneration and cognitive impairment at 4 months and abnormal hyperphosphorylation and aggregation of tau and intraneuronal accumulation of amyloid-β at 13 months.
|
23948903 |
2013 |
|
Schwannomatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.
|
24443315 |
2014 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HLA-A2-restricted TCR-transduced (TD) CIK directed against the melanoma antigens Mart1 and NY-ESO1 were generated by lentiviral transduction and successfully expanded over a 3-4-week period.
|
25758764 |
2015 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
And, increased ESCO1 expression was significantly associated with higher grade (P < 0.001), higher tumor stage (P = 0.014), and multifocality (P = 0.042).
|
26547586 |
2016 |