|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
SLC22A12 is a major gene for hypouricemia but not hyperuricemia in Japanese.
|
15327384 |
2004 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because genetic background is known to affect serum urate levels, we hypothesized that genetic variations in SLC22A12 may predispose humans to hyperuricemia and gout.
|
16920156 |
2006 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Mutations or polymorphisms in exons 4 and 5 and intron 4 of urate transporter 1 may be independent genetic markers of hyperuricemia and gout.
|
17278928 |
2007 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Certain polymorphisms in SLC22A12 may be associated with the development of hyperuricemia or gout, although confirmation is needed.
|
18349750 |
2008 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricaemia in Han Chinese.
|
19833602 |
2010 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4×10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6×10(-10)).
|
23238572 |
2013 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Complex analysis of urate transporters SLC2A9, SLC22A12 and functional characterization of non-synonymous allelic variants of GLUT9 in the Czech population: no evidence of effect on hyperuricemia and gout.
|
25268603 |
2014 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This case-control study was designed to analyse whether hURAT1 might also be a candidate gene for hyperuricaemia or hypouricaemia.
|
26603249 |
2015 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
101 hypertensive patients with hyperuricemia were detected the genotypes of URAT1 rs1529909 and rs3825016 and undergo a 2-weeks following losartan treatment.
|
26086348 |
2015 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in 4,902 health examination participants, the URAT1 nonfunctional variants significantly reduce the risk of hyperuricemia (P = 6.7 × 10(-19); risk ratio = 0.036 in males).
|
26821810 |
2016 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate effects of BDEO on XOD and URAT1 in vitro, as well as the possible mechanism by which BDEO attenuated hyperuricemia in vivo.
|
27951420 |
2017 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Discovery of Flexible Naphthyltriazolylmethane-based Thioacetic Acids as Highly Active Uric Acid Transporter 1 (URAT1) Inhibitors for the Treatment of Hyperuricemia of Gout.
|
27633583 |
2017 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Resveratrol contributes to URAT1 expression, which is potentially useful in therapeutic strategies aimed at treating hyperuricemia.
|
28499081 |
2017 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia.
|
28623927 |
2017 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
GAE and GAW downregulated the level of CNT2 proteins in the gastrointestinal tract of hyperuricemia mice.Thus, <i>G. applanatum</i> produced outstanding hypouricemic effects, mediated by renal OAT1, GLUT9, and URAT1 and gastrointestinal CNT2 that might elevate urine uric secretions and decline in the absorption of purine in the gastrointestinal tracts.<i>G. applanatum</i> showed little negative influence on inner organs.
|
29379442 |
2017 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS GPS may be an effective treatment for hyperuricemia via a decrease in xanthine oxidoreductase through the XOD/XDH system; and via an increase in urate excretion through regulating URAT1, GLUT9, and OAT1 transporters.
|
28258276 |
2017 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout.
|
28386072 |
2017 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found the significant decrease in protein expression of URAT1 and GLUT9, and the significant increase in protein expression of OAT1 in the kidney in AFPR treated groups compared to the model groups of hyperuricemia.
|
29490297 |
2018 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We observed that the two flavones possess potent effect in hyperuricemia mice by decreasing the level of mURAT1 and inhibiting XO activity, which contribute to enhancing uric acid (UA) excretion and improving hyperuricemia-induced renal dysfunction.
|
29519319 |
2018 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9.
|
29990831 |
2018 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, serum and hepatic XOD activities and renal URAT1 expression declined in J99745-treated hyperuricemia mice.
|
29719791 |
2018 |
|
Hyperuricemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter in clinical development for treating gout and asymptomatic hyperuricaemia.
|
29868853 |
2018 |
|
Hyperuricemia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The expression of URAT1 was returned to normal, resulting in an increase of renal urate excretion and consequent healing of adenine-induced hyperuricemia in mice.
|
30486413 |
2018 |
|
Hyperuricemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of hyperuricemia among the Chinese population of the southeast coastal region and association with single nucleotide polymorphisms in urate‑anion exchanger genes: SLC22A12, ABCG2 and SLC2A9.
|
30015934 |
2018 |