Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Osteogenic regulators Runx2 and OSX, and the late marker osteopontin (OPN) expressed at low levels in most OS lines, indicating that most OS cells fail to undergo terminal differentiation.
|
18838962 |
2008 |
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We used quantitative real-time polymerase chain reaction to evaluate the gene expression of MDM2, CXCR4, RANKL, RB1, and OSTERIX in 98 samples of osteosarcoma taken from 47 patients (74 metastases and 24 primary tumors) and 30 nonmalignant lung tissues surrounding osteosarcoma metastases.
|
23845465 |
2013 |
Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection.
|
15734992 |
2005 |
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection.
|
15734992 |
2005 |
Osteosarcoma of bone
|
0.030 |
Biomarker
|
disease |
BEFREE |
We used quantitative real-time polymerase chain reaction to evaluate the gene expression of MDM2, CXCR4, RANKL, RB1, and OSTERIX in 98 samples of osteosarcoma taken from 47 patients (74 metastases and 24 primary tumors) and 30 nonmalignant lung tissues surrounding osteosarcoma metastases.
|
23845465 |
2013 |
Osteosarcoma of bone
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Osteogenic regulators Runx2 and OSX, and the late marker osteopontin (OPN) expressed at low levels in most OS lines, indicating that most OS cells fail to undergo terminal differentiation.
|
18838962 |
2008 |
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection.
|
15734992 |
2005 |
Childhood Osteosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We used quantitative real-time polymerase chain reaction to evaluate the gene expression of MDM2, CXCR4, RANKL, RB1, and OSTERIX in 98 samples of osteosarcoma taken from 47 patients (74 metastases and 24 primary tumors) and 30 nonmalignant lung tissues surrounding osteosarcoma metastases.
|
23845465 |
2013 |
Childhood Osteosarcoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Osteogenic regulators Runx2 and OSX, and the late marker osteopontin (OPN) expressed at low levels in most OS lines, indicating that most OS cells fail to undergo terminal differentiation.
|
18838962 |
2008 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection.
|
15734992 |
2005 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Tumor-induced bone was reduced in trigenic mice (Tie2<sup>cre</sup>/Osx<sup>f/f</sup>/SCID) with endothelial-specific deletion of osteoblast cell-fate determinant OSX compared with bigenic mice (Osx<sup>f/f</sup>/SCID).
|
28586644 |
2017 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We used quantitative real-time polymerase chain reaction to evaluate the gene expression of MDM2, CXCR4, RANKL, RB1, and OSTERIX in 98 samples of osteosarcoma taken from 47 patients (74 metastases and 24 primary tumors) and 30 nonmalignant lung tissues surrounding osteosarcoma metastases.
|
23845465 |
2013 |
Nodule
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Interestingly, rapamycin in rapamycin plus lipopolysaccharide (LPS)‑treated BMSCs significantly increased the gene expression levels of Sp7 transcription factor, runt related transcription factor 2, alkaline phosphatase (ALP) and collagen I (Col I), ALP activity, and calcium nodule at different time points in vitro, indicating that osteoblast differentiation occurs by rapamycin when BMSCs are exposed to LPS simultaneously.
|
28990080 |
2017 |
Osteogenesis Imperfecta
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta.
|
29405385 |
2018 |
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection.
|
15734992 |
2005 |
Giant Cell Tumor of Bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of bone.
|
15003787 |
2004 |
Craniofacial Abnormalities
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mutations of the Sp7 gene in humans are associated with craniofacial anomalies and osteogenesis imperfecta.
|
29405385 |
2018 |
Peripheral ossifying fibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of Osterix protein in the pathogenesis of peripheral ossifying fibroma.
|
28678972 |
2017 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We used quantitative real-time polymerase chain reaction to evaluate the gene expression of MDM2, CXCR4, RANKL, RB1, and OSTERIX in 98 samples of osteosarcoma taken from 47 patients (74 metastases and 24 primary tumors) and 30 nonmalignant lung tissues surrounding osteosarcoma metastases.
|
23845465 |
2013 |
MYELODYSPLASTIC SYNDROME
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results revealed that proliferation, apoptosis and the mRNA expression levels of RUNX2 and SP7 in MDS-MSCs did not significantly change following treatment with decitabine compared with control MDS-MSCs.
|
31611955 |
2019 |
OSTEOGENESIS IMPERFECTA, TYPE XII
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
OSTEOGENESIS IMPERFECTA, TYPE XII
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
|
19801982 |
2009 |
Bone Density
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New sequence variants associated with bone mineral density.
|
19079262 |
2009 |