CCR7, C-C motif chemokine receptor 7, 1236

N. diseases: 320; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.100 Biomarker disease BEFREE Interestingly, Fim-3 is tightly linked to Evi-1, another common integration site of ecotropic virus involved in another model of mouse myeloid leukemogenesis. 2902233 1988
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.020 AlteredExpression disease BEFREE During studies to determine the role of the Evi-1 gene in the transformation of human cells, we have found that the Evi-1 gene is uniquely expressed at low levels in HEC-1-A cells and at high levels in HEC-1-B cells, two related human endometrial carcinoma cell lines. cDNA clones were isolated and sequenced from the HEC-1-B cell line. 2115646 1990
CUI: C0023418
Disease: leukemia
leukemia 		0.100 Biomarker disease BEFREE Specific gene activation (N-myc, evi-1) or fusion genes such as the alpha retinoic acid receptor (alpha RAR) and pml have been identified as the specific cause of some cases of leukemia. 1434816 1992
CUI: C0023418
Disease: leukemia
leukemia 		0.100 Biomarker disease BEFREE Steady-state evi-1 transcripts were detected in UCSD/AML1 and murine leukemia M1 cells, but were not present in HL60 or Namalwa human leukemia cells. 1593910 1992
CUI: C0023418
Disease: leukemia
leukemia 		0.100 AlteredExpression disease BEFREE Ectopic strong expression of Evi-1 in human leukemias could define an uncommon subclass of acute myelogenous leukemias with translocations involving the 3q25-28 chromosomal domain and abnormal megakaryopoiesis. 1552747 1992
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 AlteredExpression disease BEFREE Ectopic strong expression of Evi-1 in human leukemias could define an uncommon subclass of acute myelogenous leukemias with translocations involving the 3q25-28 chromosomal domain and abnormal megakaryopoiesis. 1552747 1992
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease BEFREE To evaluate the role of the EVI1 gene in human acute myelogenous leukemia (AML), leukemic blasts or cell lines from 116 patients were examined. 1570317 1992
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia 		0.100 AlteredExpression disease BEFREE Retroviral activation of Evi-1 gene expression is one of the most common transforming events in murine myeloid leukemias. 1570317 1992
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Steady-state evi-1 transcripts were detected in UCSD/AML1 and murine leukemia M1 cells, but were not present in HL60 or Namalwa human leukemia cells. 1593910 1992
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 Biomarker disease BEFREE Specific gene activation (N-myc, evi-1) or fusion genes such as the alpha retinoic acid receptor (alpha RAR) and pml have been identified as the specific cause of some cases of leukemia. 1434816 1992
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.100 GeneticVariation disease BEFREE Expression of the EVI1 gene in chronic myelogenous leukemia in blast crisis. 8412328 1993
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.100 AlteredExpression disease BEFREE EVI1 is also expressed by cells from AML patients with chromosome rearrangements involving band 3q26, the putative location of the EVI1 gene, but expression of this gene is not detected in normal bone marrow. 8412328 1993
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 AlteredExpression disease BEFREE EVI1 is also expressed by cells from AML patients with chromosome rearrangements involving band 3q26, the putative location of the EVI1 gene, but expression of this gene is not detected in normal bone marrow. 8412328 1993
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.100 AlteredExpression disease BEFREE We report expression of EVI1 by cells from a patient with chronic myelogenous leukemia in blast crisis (CML/BC) whose cells showed inv(3)(q22q26). 8412328 1993
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.070 AlteredExpression group BEFREE Patients with CML/BC and other nonrandom chromosome abnormalities involving chromosome 3q26 should be evaluated for EVI1 expression. 8412328 1993
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.100 AlteredExpression disease BEFREE EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. 7808006 1994
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE These studies document for the first time the abnormal expression of EVI1 RNA by patients with MDS, and suggest an important role for EVI1 in the pathogenesis or progression of some myeloid malignancies. 8049440 1994
CUI: C0023418
Disease: leukemia
leukemia 		0.100 AlteredExpression disease BEFREE EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. 7808006 1994
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 AlteredExpression disease BEFREE Karyotypes showed that only one AML patient had karyotype 3q26 abnormalities, indicating that EVI1 expression is associated with cases that do not have structural abnormalities involving chromosome 3q26. 8049440 1994
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease BEFREE We have studied six individuals with AML and inv(3)(q21q26) for disruptions to the EVI1 locus by in situ hybridization and long-range mapping. 8118036 1994
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease BEFREE In these studies, four additional cases of AML with inv(3)(q21q26) are shown to express the EVI1 gene and to have breakpoints 3' of the gene. 7919381 1994
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.100 Biomarker disease BEFREE These results indicate that EVI1 expression in YS9;22 cells is linked to the 3q26 abnormality and that EVI1 activation plays an oncogenic role in the blastic transformation of chronic myeloid leukemia. 7808006 1994
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.100 AlteredExpression disease BEFREE EVI1 expression associated with a 3q26 anomaly in a leukemia cell line derived from the blast crisis of chronic myeloid leukemia. 7808006 1994
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.100 AlteredExpression group BEFREE EVI1 RNA was expressed in 29% of 34 (95% confidence interval, 20% to 50%) patients with the MDS subtypes refractory anemia (RA), refractory anemia with excess blasts (RAEB), or refractory anemia with excess blasts in transformation (RAEB-T). 8049440 1994
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms 		0.090 AlteredExpression group BEFREE The vast majority of these cases occurred in patients with RAEB and RAEB-T. EVI1 expression was not detected in patients with chronic myelomonocytic leukemia (CMML), normal bone marrow or cord blood, or a variety of other hematologic malignancies. 8049440 1994