Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
Paroxysmal atrial fibrillation
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
Persistent atrial fibrillation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
familial atrial fibrillation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Here, we tested the hypothesis that the zona pellucida-binding protein 2 (ZPBP2) gene residing in this region contributes to asthma pathogenesis using a mouse model.
|
29536159 |
2018 |
Asthma
|
0.180 |
AlteredExpression
|
disease |
BEFREE |
Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB).
|
28241063 |
2017 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The first GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1).
|
25433770 |
2016 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
Asthma
|
0.180 |
PosttranslationalModification
|
disease |
BEFREE |
The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status.
|
26671913 |
2016 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Combined with the results of the present work, these data converge pointing to the same 5 kb region within the ZPBP2 gene as a critical region for both gene expression regulation and predisposition to asthma.
|
23546690 |
2013 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We found that a single nucleotide polymorphism rs4795397 influences the activity of ZPBP2 promoter in vitro in an allele-dependent fashion, and also leads to nucleosome repositioning on the asthma-associated allele.
|
22271045 |
2012 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
Asthma
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
|
19732864 |
2009 |
Primary biliary cirrhosis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Here, we show an efficient approach for identification of a functional variant in a primary biliary cholangitis (PBC)-susceptible region, chromosome 17q12-21 (ORMDL3-GSDMB-ZPBP2-IKZF3).
|
28588209 |
2017 |
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.110 |
Biomarker
|
disease |
BEFREE |
The susceptibility allele was also associated with the increased expression of GSDMA (P = 1.6 × 10(-4)) and LRRC3C (P = 7.8 × 10(-6)) in colon tissue from individuals without IBD and with the reduced expression of PGAP3 (IBD; P = 2.0 × 10(-3)) and ZPBP2 (Crohn's disease; P = 7.7 × 10(-4)) in noninflamed ileum.
|
26484354 |
2015 |
Primary biliary cirrhosis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.
|
22936693 |
2012 |
Primary biliary cirrhosis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.
|
22961000 |
2012 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
|
30013184 |
2018 |
Cholangitis, Sclerosing
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |