|
Heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blot and qRT-PCR analyses demonstrated that ADAMTS16 was significantly up-regulated in mice with transverse aortic constriction (TAC) associated with left ventricular hypertrophy and heart failure, which was correlated with increased expression of Mmp2, Mmp9, Col1a1 and Col3a1.
|
31297506 |
2020 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether children with inflammatory CD (B1) who later develop strictures (B2) have increased plasma levels of COL3A1 or COMP at diagnosis, compared with children who remain B1.
|
30213581 |
2019 |
|
Pterygium
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium.
|
31341891 |
2019 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In particular, we focused on the effects of the overexpression of collagen type III alpha 1 chain (COL3A1) in iCCA, thus providing evidences that COL3A1 promotes iCCA cells migration and is a component of tumor-associated aligned collagen.
|
31687002 |
2019 |
|
Nonspecific interstitial pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The IMU-COLV mice presented with increased tissue elastance and a nonspecific interstitial pneumonia (NSIP) histologic pattern in the lung, combined with the thickening of the small and medium intrapulmonary arteries, increased Col V fibers, and increased COL1A1, COL1A2, COL3A1, COL5A1, and COL5A2 gene expression.
|
31829272 |
2019 |
|
Pterygium Of Conjunctiva And Cornea
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium.
|
31341891 |
2019 |
|
Intestinal fibrosis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The extracellular matrix components, collagen type III alpha 1 chain (COL3A1) and cartilage oligomeric matrix protein (COMP), could contribute to intestinal fibrosis.
|
30213581 |
2019 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
In particular, we focused on the effects of the overexpression of collagen type III alpha 1 chain (COL3A1) in iCCA, thus providing evidences that COL3A1 promotes iCCA cells migration and is a component of tumor-associated aligned collagen.
|
31687002 |
2019 |
|
Pterygium of eye
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-29b-3p and collagen family (COL4A1 and COL3A1) might be new treatment target in pterygium.
|
31341891 |
2019 |
|
Diverticular disease of colon
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study shows that a variant of COL3A1 (rs3134646) is associated with the risk of developing colonic diverticulosis in white men, whereas rs1800255 (COL3A1) and rs1800012 (COL1A1) were not associated with this condition after adjusting for confounding factors.
|
29533249 |
2018 |
|
neurofibroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of type III collagen (COL3A1) also suppressed the proliferation of neurofibroma cells, whereas expression of COL3A1 and SOX2 was increased in tranilast-resistant cells, suggesting that COL3A1 and the transcription factor SOX2 might contribute to the development of tranilast resistance.
|
29666462 |
2018 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.
|
30518744 |
2018 |
|
Schistosomiasis japonica
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study explored in vivo and vitro effects of miR-29b-3p in granulomatous liver fibrosis by targeting COL1A1 and COL3A1 in Schistosoma japonicum infection.
|
29091295 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.
|
30518744 |
2018 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study aims to elucidate the mechanisms how microRNA-129-5p (miR-129-5p) involved in the neuroprotective effect of dexmedetomidine (DEX) on hypoxic-ischemic brain injury (HIBI) by targeting the type III procollagen gene (COL3A1) through the Wnt/β-catenin signaling pathway in neonatal rats.
|
29377229 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.
|
30518744 |
2018 |
|
Diverticulosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A Variant of COL3A1 (rs3134646) Is Associated With Risk of Developing Diverticulosis in White Men.
|
29533249 |
2018 |
|
Pneumonitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The lung of BLM group developed pneumonitis with severe cellular infiltrations at 7 days and significant collagen deposition (MT) and higher expression of Col1a1, and Col3a1 at 21 days post-administration.
|
29497425 |
2018 |
|
Amebiasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The significant enriched pathway (PI3K-Akt) for up-regulated genes such as COL4A1, COL4A2, EGFR, FGFR1, LAPR6, MYC, PDGFA, SPP1 were selected as well as significant GO term (ear development) for up-regulated genes such as CELSR1, CHRNA9, DDR1, FGFR1, GLI2, LGR5, SOX2, TSHR were selected, while the significant enriched pathway (amebiasis) for down-regulated gene such as COL3A1, COL5A2, LAMA2 were selected as well as significant GO term (RNA polymerase II core promoter proximal region sequence-specific binding (5) such as MEIS2, MEOX2, NR2E1, PITX2, TFAP2B, ZFPM2 were selected.
|
28952134 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of COL3A1 confers a poor prognosis in human bladder cancer identified by co-expression analysis.
|
29050298 |
2017 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of COL3A1 confers a poor prognosis in human bladder cancer identified by co-expression analysis.
|
29050298 |
2017 |
|
Amebic colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The significant enriched pathway (PI3K-Akt) for up-regulated genes such as COL4A1, COL4A2, EGFR, FGFR1, LAPR6, MYC, PDGFA, SPP1 were selected as well as significant GO term (ear development) for up-regulated genes such as CELSR1, CHRNA9, DDR1, FGFR1, GLI2, LGR5, SOX2, TSHR were selected, while the significant enriched pathway (amebiasis) for down-regulated gene such as COL3A1, COL5A2, LAMA2 were selected as well as significant GO term (RNA polymerase II core promoter proximal region sequence-specific binding (5) such as MEIS2, MEOX2, NR2E1, PITX2, TFAP2B, ZFPM2 were selected.
|
28952134 |
2017 |
|
Dissection of iliac artery
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the proband, a 37-year-old woman, DNA-analysis because of an asymptomatic iliac artery dissection revealed a pathogenic mutation in COL3A1 (c.980G>A; p. Gly327Asp).
|
28102592 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differentially expressed genes involved in these pathways such as Pik3r1, Foxo1, Foxo3, Scd1, Col3a1 and Fn1 might be candidate targets for treating NAFLD.
|
29137289 |
2017 |
|
Sleep Apnea, Obstructive
|
0.010 |
Biomarker
|
disease |
BEFREE |
AT of OSAS subjects showed increased inflammation (TNFA P=0.049) and fibrosis (COL3A1 P=0.02), a trend of higher HIF1A expression (P=0.06) and reduced adipogenesis (PPARG P=0.006).
|
28131740 |
2017 |