|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DRB1*03:01 was singly associated with AIH among whites (odds ratio [OR]: 3.09, P = 0.002) and carriers of DRB1*03:01 also carried DQA*05:01 and DQB1*02:01.
|
31211758 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DRB1*0301 and DRB1*0401 are confirmed as the principal susceptibility alleles for type 1 autoimmune hepatitis, and these data support the hypothesis that a lysine residue at position 71 of the DR beta-polypeptide chain may be the major risk factor.
|
9178696 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant association of autoimmune hepatitis with DRB1*0404 was found, (chi2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus.
|
9672174 |
1998 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
American patients with type 1 autoimmune hepatitis had DRB1*03 alleles more commonly than the German patients with type 2 disease (51% vs 17%, p = 0.03) and DRB1*0301 occurred more frequently in the type 1 patients (51% vs 17%, p = 0.03).
|
9399751 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls.
|
15683420 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By high-resolution analysis, the frequencies of DRB1 *0405 and DQB1 *0401 were significantly increased in patients with AIH (P = 0.0001, OR = 3.74; P = 0.00006, OR = 3.95, respectively).
|
18022727 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD4 T cells from patients with type 2 AIH positive for the predisposing HLA allele DRB1*0701 recognize seven regions of CYP2D6, five of which are also recognized by CD8 T cells.
|
18528928 |
2008 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic active autoimmune hepatitis in children. Strong association with a particular HLA-DR6 (DRB1*1301) haplotype.
|
7860360 |
1994 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparison of DRB1*13- and DRB1*03-positive subjects revealed that the former alleles conferred susceptibility to younger patients with AIH type 1.
|
10406258 |
1999 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1*0301 and DRB1*0401.
|
10613727 |
2000 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA DRB1*03-DRB1*04 is a risk factor for type-1 autoimmune hepatitis, and its impact on outcome relates to the diversity of DRB1*04 alleles that encode a critical motif.
|
17105585 |
2006 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, DRB1(∗)11 was less frequent in AIH patients.
|
26780502 |
2016 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes.
|
22797478 |
2010 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our data indicate that type 1 AIH predisposition in a Venezuelan mestizo population of different ethnic backgrounds is associated with DRB1*1301 and DRB1*0301 alleles.
|
17927716 |
2007 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In PCR-RFLP typing, the frequency of DRB1*0405 was significantly higher in autoimmune hepatitis than in controls.
|
1354193 |
1992 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In subtypes of DR4, there was a trend of increase in the gene frequency of DRB1 0405 in patients with AIH versus healthy controls (21.9% vs 6.3%, P=0.04, but P(c) =0.08).
|
11819862 |
2001 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Increased frequencies of both HLA-DRB1*04:04:01 and *16:02:01:01 alleles (OR = 2.91; 95% CI = 1.08-7.84) and the haplotype (DRB1-TNFA-LTA) *04:04:01-G-A (OR = 5.33; 95% CI = 1.32-21.49) were observed in AIH patients.
|
31570816 |
2019 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis.
|
21480110 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic β chain of the HLA-DR antigen.
|
20957499 |
2011 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies of type 1 AIH have focused on the major histocompatibility complex (MHC), mapping susceptibility to the DRB1 region.
|
12447707 |
2002 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility for type 1 autoimmune hepatitis has been associated with the major histocompatibility alleles DRB1*0301, DRB3*0101, DRB1*0401, and DRB4*0103, whereas the DRB1*1501 allele may protect from the disease.
|
9021941 |
1997 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*0405-DQB1*0401 haplotype in autoimmune pancreatitis showed no significant association with any HLA class I antigens, in contrast to the B54-DRB1*0405-DQB1*0401 haplotype reported in autoimmune hepatitis.
|
11984513 |
2002 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*04:05-DQB1*04:01 haplotype was significantly associated with AIH susceptibility (30% vs. 11%, P = 1.2×10(-10); odds ratio [OR] = 3.51) and correlated with elevated serum IgG (3042 vs. 2606 mg/dL, P = 0.041) and anti-smooth muscle antigen positivity (77% vs. 34%, P = 0.000006).
|
24956105 |
2014 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C allele of rs7708392 was associated with AIH, especially AIH without DRB1*04:05, an already established risk factor.
|
29559739 |
2018 |
|
Autoimmune Chronic Hepatitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of deleterious alleles in TNFAIP3 was higher in the AIH subset without the DRB1 risk alleles than that with (P = 0.0052, OR 5.10, 95%CI 1.55-16.74).
|
31138864 |
2019 |