|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
|
11752579 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a recent study, KLF6 was reported as a tumor suppressor gene in prostate cancer because of its frequent loss of heterozygosity (LOH) and mutation as well as functional suppression of cell proliferation.
|
12651626 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas.
|
12740910 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aims of the present study were to confirm these initial findings by determining the frequency of exon2 KLF6 mutations in a cohort of European prostate cancer patients, and to investigate whether there was evidence for mutational inactivation of both the KLF6 and TP53 tumour suppressor loci in some tumours.
|
12915879 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MXI1, DMBT1, and KLF6 were excluded as important tumor-suppressor genes.
|
14732919 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The KLF6 locus was deleted in at least 55% of tumors, and mutations were identified in 44%.
|
15057748 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Indeed, mutations of the KLF6 gene have recently been reported in this tumor type.
|
15064720 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also studied the expression of the WAF1 gene, a possible downstream gene of KLF6, and detected simultaneous down-regulation of WAF1 and KLF6 mRNA in 6 of 9 (67%) cell lines and 48 of the 55 (87%) primary tumors, although there was not a significant association between loss of KLF6 and WAF1 expression.
|
15172991 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, we propose that KLF6 is deregulated by loss and/or mutation in HCC, and its inactivation may contribute to pathogenesis in a significant number of these tumors.
|
15486921 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The KLF6 variant proteins KLF6-SV1 and KLF6-SV2 are mislocalized to the cytoplasm, antagonize wtKLF6 function, leading to decreased p21 expression and increased cell growth, and are up-regulated in tumor versus normal prostatic tissue.
|
15735005 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The KLF6 is a zinc-finger tumor suppressor that is frequently mutated in several human cancers and broadly involved in differentiation and development, growth-related signal transduction, cell proliferation, apoptosis, and angiogenesis.
|
15824733 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple lines of evidence now suggest that KLF6 is a key prostate cancer tumor suppressor gene including loss and/or mutation in prostate cancer tumors and cell lines and decreased KLF6 expression levels in recurrent prostate cancer samples.
|
15994951 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Absence of mutation in the putative tumor-suppressor gene KLF6 in colorectal cancers.
|
16044160 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Krüppel-like factor 6 (KLF6) is a zinc finger transcription factor and tumor suppressor that is inactivated in a number of human cancers by mutation, allelic loss, and/or promoter methylation.
|
16230382 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple genes associated with aggressive behavior were increased in the androgen-independent metastatic tumors (MMP9, CKS2, LRRC15, WNT5A, EZH2, E2F3, SDC1, SKP2, and BIRC5), whereas a candidate tumor suppressor gene (KLF6) was decreased.
|
16510604 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Results indicated that EEF1A2 and KLF6 were strong candidates of oncogene and tumour suppressor genes, respectively.
|
16517066 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistically, loss of KLF6 expression was significantly associated with tumor size (P < 0.05).
|
16610031 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor KLF6 is a member of the Krüppel-like family of transcription factors, which has been implicated in the pathogenesis of several human carcinomas.
|
16702959 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Consistent with these findings, KLF6 silencing increased cellular and tumor growth, angiogenesis, and vascular endothelial growth factor expression, i.p. dissemination, and ascites production.
|
16778100 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data further support that the KLF6 gene may be one of the candidate tumor suppressor genes in colorectal cancers and that genetic alteration of the KLF6 gene might play a role in the development of colorectal carcinomas.
|
16856969 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Kruppel-like factor 6 (KLF6) is a zinc finger tumor suppressor gene that is frequently mutated in several human cancers and is broadly involved in differentiation and development, growth-related signal transduction, cell proliferation, apoptosis, and angiogenesis.
|
16872311 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas.
|
16972326 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deregulation of KLF6 stability may alter its tumor suppressor function and/or the response of tumors to chemotherapeutics.
|
17113081 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Kruppel-like factor 6 (KLF6/Zf9/CPBP), a member of the Kruppel-like family of zinc finger transcription factors, has recently been suggested to be a mutated tumor suppressor in selected human cancers.
|
17143513 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, the absence of somatic mutations suggests the uncertainty of the KLF6 gene as a classical tumor suppressor gene at the lost 10p15 region in colorectal carcinogenesis.
|
17347589 |
2006 |