ZFP42, ZFP42 zinc finger protein, 132625

N. diseases: 30; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206664
Disease: Teratocarcinoma
Teratocarcinoma 		0.010 AlteredExpression disease BEFREE We compared the transcriptional regulation of the human Rex1 gene in NTera-2 (NT-2) human teratocarcinoma, normal human prostate epithelial cells (PrEC), and prostate cancer cells (PC-3) by promoter/luciferase analyses. 20232320 2010
CUI: C3714948
Disease: PACHYONYCHIA CONGENITA 3
PACHYONYCHIA CONGENITA 3 		0.010 AlteredExpression disease BEFREE This lack of positive transcriptional regulation by the hRex1 protein may be responsible for the lack of Rex1 expression in PC-3 prostate cancer cells. 20232320 2010
CUI: C0007133
Disease: Carcinoma, Papillary
Carcinoma, Papillary 		0.010 Biomarker disease BEFREE Immunohistochemical staining confirmed the absence of REX1 in three renal tumor specimens (two clear cell and one papillary carcinoma), while the REX1 protein was detected in a small percentage of proximal tubular cells in normal renal tissue. 16344273 2006
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.010 Biomarker disease BEFREE Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. 16344273 2006
CUI: C0022665
Disease: Kidney Neoplasm
Kidney Neoplasm 		0.010 AlteredExpression disease BEFREE We found that 14 of 15 (93%) non-tumor renal parenchymal specimens demonstrated Rex-1 mRNA, compared with 5 of 14 (36%) renal tumors (P < 0.005). 16344273 2006
CUI: C0206659
Disease: Embryonal Carcinoma
Embryonal Carcinoma 		0.010 Biomarker disease BEFREE Comparison of embryonal carcinoma with seminomas revealed relative overexpression of several stem cell-associated genes in embryonal carcinoma, including several core "stemness" genes (EBAF, TDGF1, and SOX2) and several downstream targets of WNT, NODAL, and FGF signaling (FGF4, NODAL, and ZFP42). 16424014 2006
CUI: C0206681
Disease: Adenocarcinoma, Clear Cell
Adenocarcinoma, Clear Cell 		0.010 AlteredExpression disease BEFREE There were no differences in Rex-1 mRNA or protein expression among the various histologic subtypes of renal tumors (clear cell carcinoma, papillary carcinoma, chromophobe carcinoma and oncocytoma). 16344273 2006
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.010 Biomarker disease BEFREE Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. 16344273 2006
CUI: C0949541
Disease: Hurthle Cell Tumor
Hurthle Cell Tumor 		0.010 AlteredExpression disease BEFREE There were no differences in Rex-1 mRNA or protein expression among the various histologic subtypes of renal tumors (clear cell carcinoma, papillary carcinoma, chromophobe carcinoma and oncocytoma). 16344273 2006
CUI: C1378050
Disease: Oncocytic Neoplasm
Oncocytic Neoplasm 		0.010 AlteredExpression disease BEFREE There were no differences in Rex-1 mRNA or protein expression among the various histologic subtypes of renal tumors (clear cell carcinoma, papillary carcinoma, chromophobe carcinoma and oncocytoma). 16344273 2006
CUI: C1510502
Disease: Oxyphilic Adenoma
Oxyphilic Adenoma 		0.010 AlteredExpression disease BEFREE There were no differences in Rex-1 mRNA or protein expression among the various histologic subtypes of renal tumors (clear cell carcinoma, papillary carcinoma, chromophobe carcinoma and oncocytoma). 16344273 2006